Maxalt contraindications and warnings

Contraindications

Following is information on contraindications to the use of rizatriptan in general, pregnancy & breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should Rizatriptan not be used?

The active substance should not be taken in case of hypersensitivity to rizatriptan, heart attack, circulatory disorders of the heart such as angina pectoris or Prinzmetal angina, cardiac vascular spasms (ischaemias), vascular disease, hypertension, circulatory disorders of the brain, severe renal insufficiency or severe hepatic dysfunction be.

Rizatriptan should be used only if the diagnosis of migraine is confirmed and other brain disorders have been excluded. In certain forms of migraine, however, the active substance must not be used. These include the so-called hemiplegic migraine, which is characterized by a very pronounced auraphase, the basilar migraine, the result of a circulatory disorder, and the ophthalmoplegic migraine, which is based on an ocular muscle palsy.

Concomitant administration of rizatriptan and ergotamine or ergotamine derivatives (including methysergide) or other 5-hydroxytryptamine receptor agonists should be avoided. After taking any of these drugs, at least 24 hours should elapse before rizatriptan is administered.

As with other 5-HT1 receptor agonists, rizatriptan should not be given to patients who have risk factors for coronary heart disease (CHD) without prior cardiac medical examination. Also, patients who are heavy smokers or undergo nicotine replacement therapy should take the drug only after careful medical examination. Special attention must be paid to postmenopausal women and men over the age of 40 with these risk factors.

Rizatriptan is not recommended for children and adolescents under the age of 18 years. For use in elderly patients over the age of 65 years, the efficacy and tolerability of rizatriptan has not been adequately studied.

What should you watch out for during pregnancy and lactation?

Pregnant women should receive the active substance only after a strict risk-benefit assessment by the doctor, because there are no adequate studies for use during pregnancy.

After taking Rizatriptan, do not breast-feed for at least 24 hours as the active substance passes into breast milk and should be avoided from loading the baby.

What should be considered in children?

The active substance is not suitable for children and adolescents under 18 years of age.

Warnings and Precautions

  • If skin and mucous membrane swelling (angioedema) occurs, the active ingredient must be discontinued immediately.
  • This ingredient may alter the ability to react so much as to impair the ability to drive or operate machinery. This applies even more in combination with alcohol.

Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.