What side effects can Lorazepam have?
Below you will find the most important information about possible known side effects of Lorazepam.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Common side effects:
tiredness, drowsiness, drowsiness, dizziness, drowsiness, limited ability to react.
Rare side effects:
Muscle weakness, sex drive decline, depression, low blood pressure, dry mouth, superficial breathing.
Very rare side effects:
Allergic skin reactions such as itching, rash.
Sporadic side effects:
Menstrual disorders, psychosis, gall bladder.
Side effects without frequency:
nausea, bitter sensation of taste, confusion, gait insecurity, movement insecurity, speech disorders (articulation disorders), muscle spasms, restlessness, insomnia, memory disorders, blurred vision, diplopia, ocular twitching, photosensitivity, liver function elevation, development of tolerance, coordination disorders, concentration disorders, Headache, heartburn, gastrointestinal discomfort, hypersensitivity reactions such as allergies, confusion, adverse reactions (eg, acute agitation, tantrums), memory gaps, deficiency of the hormone ADH, low sodium concentration in the blood, elevation of body temperature, low blood pressure, jaundice, changes in the blood count such as reduction of all blood cells, thrombocytopenia and agranulocytosis, impotence, orgasm disorders, tremors, cramps, hair loss, euphoria, suicidal thoughts, suicide attempts.
The use of benzodiazepines such as lorazepam, especially in elderly patients or children, may lead to psychiatric and “paradoxical” reactions such as agitation, irritability, aggressiveness, anger, nightmares, hallucinations, psychosis, inappropriate behavior and other behavioral problems. In such cases the treatment with the active substance should be stopped.
After prolonged ingestion and sudden discontinuation of lorazepam occur sleep disorders and increased dreams, anxiety, tension, agitation, inner restlessness, trembling, sweating, increased spasms with seizures and psychosis with memory disorders, thought disorders and delusions. Treatment with the drug should therefore always be stopped with slowly reduced doses.
What interactions does Lorazepam show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Concomitant use of other sleeping pills, tranquilizers, anti-anxiety drugs, anti-depressant drugs (antidepressants such as lithium), and psychotic and excitatory agents (neuroleptics) may increase the effectiveness of each other. The same applies to the concomitant use of antiepileptic drugs (anticonvulsants), AT1 receptor antagonists (antihistamines) and opioid analgesics.
In addition, the combination with opioid analgesics or anesthetics can lead to a faster development of dependence by Lorazepam.
In addition, H2-receptor blockers such as cimetidine, proton pump inhibitors such as omeprazole, and estrogen-progestagen contraceptive combinations (such as the pill) and macrolide antibiotics such as erythromycin may enhance lorazepam activity.
The concomitant use of muscle relaxants (muscle relaxants) increases their effect. The same applies to non-opioid analgesics and nitrous oxide.
No alcohol should be consumed during treatment with Lorazepam as the lorazepam effect is altered and / or increased in an unpredictable manner. Also, the ability to drive and the ability to operate machines is additionally impaired by the combination of alcohol and lorazepam.
Furthermore, interactions with hypertensives, beta-blockers (to relieve the heart and reduce blood pressure) or anticoagulants (anticoagulants) are also unpredictable.
The active ingredient clozapine, together with lorazepam, has a pronounced depressant effect, so it greatly reduces responsiveness and alertness.
Valproic acid from the group of antiepileptic drugs and the ointment Probenecid increase the blood concentration of lorazepam and reduce its excretion via the kidney. Both enhance the effects of Lorazepam. It is therefore necessary that the doctor reduces the dose of lorazepam by about half with the administration of these drugs.
The asthma drugs Theophylline and Amiphyllin decrease the soothing effects of Lorazepam.