Lisinopril contraindications and warnings


The following is information on contraindications to the use of lisinopril in general, pregnancy & breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should Lisinopril not be used?

Lisinopril must not be used with

  • Patients with hypersensitivity to ACE inhibitors
  • Facial swelling, a history of Quincke’s edema
  • to low blood pressure
  • diabetics or patients with impaired kidney function who receive the antidiabetic aliskiren
  • Patients with a transplanted kidney, a narrowing of the renal arteries (renal artery stenosis) or with only one healthy kidney
  • primary hyperaldosteronism, a high blood pressure disease because all ACE inhibitors are ineffective there
  • Heart valve defects such as constricted aortic and / or mitral valves
  • Heart muscle disease with enlargement of the heart (hypertrophic cardiomyopathy)
  • Patients after acute myocardial infarction with further symptoms
  • Shock patients because they have less heart pumping power
  • Patients who need regular blood work (dialysis) – Lisinopril should not be used with poly (acrylonitrile-sodium-2-methylallyl sulfonate) high-flow membranes.

Lisinopril may only be used in cases of special skin diseases, collagenosis and other autoimmune diseases, under strict medical consideration of benefit and risk.

What should you watch out for during pregnancy and lactation?

The administration of lisinopril is strictly prohibited during pregnancy.

Since the active substance is excreted in breast milk, its use is also prohibited during breast-feeding. Women who become pregnant during Lisinopril therapy should be made aware of the potential danger to the unborn child.

What should be considered in children?

The safety and efficacy of lisinopril is not proven in children. Therefore, the drug should not be used in this age group.

Warnings and Precautions

  • The drug can cause a sharp fall in blood pressure. Because this can be dangerous especially in surgery, the surgeon should be told to take it.
  • The drug may worsen the condition of the circulatory system after an acute myocardial infarction.
  • The drug can cause severe hypotension and kidney failure in patients with renal artery stenosis or renal artery hypertension.
  • The drug may cause kidney failure in patients with impaired kidney function and severe heart failure.
  • The drug may trigger a hypersensitivity reaction to shock in dialysis patients.
  • The drug can cause an increase in potassium levels.
  • The drug works in patients with impaired adrenal function (primary hyperaldosteronism).
  • The drug has a stronger effect in elderly patients – these patients need to be monitored regularly.
  • The drug may cause life-threatening allergic reactions during a desensitization therapy against insect venoms.
  • The drug can cause tissue swelling (Quincke’s edema) and can cause airway constriction.
  • Treatment with the drug often causes a dry cough that is not cold-related.
  • The drug can cause white blood cell waste.
  • If diabetics are treated with the drug, these patients must be monitored with special care.
  • The medicine is not recommended for the treatment of patients with transplanted kidneys.
  • The drug can cause anemia.
  • During treatment with the drug, the patient’s laboratory values must be regularly monitored by a doctor.
  • When driving vehicles and machines, it should be noted that occasionally dizziness and fatigue may occur.

Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.