Lisinopril side effects

What side effects can Lisinopril have?

Below you will find the most important information about possible, known side effects of Lisinopril.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).

More common side effects:
At the beginning: severe drop in blood pressure with dizziness, weakness and blurred vision.
General: kidney dysfunction, nausea, upper abdominal discomfort, indigestion, diarrhea, constipation, loss of appetite.

Uncommon side effects:
dry irritated cough, sore throat, hoarseness, bronchitis, allergic reactions to the skin, headache, fatigue, white blood cell deficiency, red blood cell deficiency, platelet deficiency, anemia, increase in blood potassium Increase in concentration, blood urea concentration increase, blood creatinine concentration increase, blood sodium concentration decrease, increased urinary protein excretion.

Rare side effects:
In patients with acute myocardial infarction: arousal blockage in the heart, marked hypotension, renal dysfunction, shock due to reduced cardiac pumping power.
General: Loss of consciousness (syncope), drowsiness, depression, sleep disorders, impotence, nervous and arm malformations, balance disorders, muscle spasms, nervousness, confusion, tinnitus, blurred vision, changes in taste, transient loss of taste, vomiting, shortness of breath, sinusitis, nasal irritation , Bronchoconstriction (up to asthma), pulmonary infiltrates, inflammations of the mouth (stomatitis), inflammation of the tongue (glossitis), dry mouth.

Isolated side effects:
palpitations, cardiac arrhythmia, chest pain, heart attack, stroke, allergic pneumonia, acute renal failure, liver dysfunction, hepatitis, liver failure, pancreatitis, intestinal obstruction.

Special features:
During the treatment with the drug the laboratory values of the liver, the kidneys and the heart should be checked regularly.

The association between lisinopril and a syndrome of jaundice, liver tissue death and death is still unclear. Nevertheless, the therapy should be stopped if jaundice occurs.

In isolated cases, tissue swelling (Quincke’s edema) involving upper respiratory tract can lead to fatal airway obstruction.

Already in case of suspected severe skin reactions with fever, muscle pain and joint pain, the therapy should be stopped and a doctor should be consulted.

What interactions does Lisinopril show?

Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).

The combination with lithium, a remedy for depression, is not recommended as lisinopril may decrease the excretion of lithium. With simultaneous use, the lithium level in the blood should be determined.

Caution is advised in combinations with baclofen (a remedy for muscle cramps), dehydrating agents, amifostine (a cell protection agent for cancer therapy), painkillers and anesthetics and sedatives, because they can increase the blood pressure drop.

  • In general, the doctor will combine other antihypertensives only cautiously. In particular, however, AT1 receptor antagonists or aliskiren are not recommended as the risk of side effects such as potassium deficiency, hypotension and decreased renal function is increased. This is especially true in patients with kidney dysfunction due to diabetes.
  • Painkillers and antiphlogistics such as. Acetylsalicylic acid or indomethacin can reduce the effect of lisinopril and reduce kidney circulation.

    Potassium-sparing dehydrating agents and potassium substitutes together with lisinopril increase the potassium concentration in the blood.

    Allopurinol (a gout drug), anti-cancer drugs, immunosuppressive drugs, oral glucocorticoids and procainamide (an anti-arrhythmic drug) in combination with lisinopril increase the risk of white blood cell depletion (leukopenia).

    Lisinopril may increase the hypoglycemic effect of medications such as oral antidiabetics or insulin.

    Acid-binding agents (antacids) can reduce the absorption of lisinopril in the body (bioavailability).

    Lisinopril enhances the effects of alcohol as well as alcohol increases the antihypertensive effect of lisinopril.

    Sympathomimetics and saline reduce blood pressure reduction.

    Potential Lisinopril side effects may include: