The following is information on contraindications to the use of Vardenafil in general, pregnancy, breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).
When should Vardenafil not be used?
The active substance should not be used in cases of hypersensitivity to vardenafil and concomitant use of alpha-adrenoceptor antagonists (alpha-sympatholytic agents) or nitro-based vasodilators (nitrates), as this may lead to severe hypotension. Also, HIV-1 protease inhibitors such as ritonavir and indinavir should not be taken concomitantly with vardenafil.
The product should not be given to patients with severe cardiovascular disease, such as unstable angina pectoris, cardiac arrhythmia, or severe Heart failure (heart failure NYHA II and III), after a stroke less than six months ago, or a heart attack (myocardial infarction within the first three months).
In case of severe renal or hepatic impairment, low blood pressure (hypotension with a systole value below 90 mmHg) or the hereditary disease of the retina (retinitis pigmentosa), vardenafil must also not be used.
Only after careful medical benefit-risk assessment of the active substance may be taken in severe arterial disease, especially with a narrowing in the aorta (aortic stenosis), a disorder of blood pressure control (multiple system atrophy), and gastric and duodenal ulcers. !!!
Patients with blood clotting disorders, sickle cell disease or certain forms of blood cancer (eg leukemia, plasmocytoma), anatomical malformations of the penis, or if priapism has already begun to be painful should not be given any other than vardenafil after consulting with their doctor. !!!
In patients with renal insufficiency (renal insufficiency) or liver dysfunction (eg cirrhosis of the liver) as well as in patients treated concomitantly with erythromycin, a reduction in the dose of vardenafil is recommended by the physician.
In men over the age of 75 years, the concomitant use of vardenafil with the active substances itraconazole and ketoconazole (in oral form) is prohibited.
What should you watch out for during pregnancy and lactation?
The active substance is only approved for use in men.
What should be considered in children?
The active substance is not suitable for children and adolescents below the age of 18.
Warnings and Precautions
- Taking the drug causes a slight fall in blood pressure.
- There may be an increased risk of myocardial infarction, arrhythmia and other life-threatening cardiovascular disorders associated with sexual activity when taking the drug.
- Be noticing a (unilateral) visual disturbance, discontinue medication immediately and consult a physician.
- The use of the drug should not be combined with other erectile dysfunction treatments.
- The medication may cause dizziness and blurred vision, which may affect your ability to react.
- Reactivity may be altered by the drug to the point of affecting the ability to drive or operate machinery. This applies even more in combination with alcohol.
Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.