What side effects can Vardenafil have?
Below you will find the most important information about possible known side effects of Vardenafil.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Very common side effects:
Headache, flushing and redness of the upper body (flush).
Common side effects:
Dizziness, stuffy nose, nausea, mild diarrhea.
Uncommon side effects:
Color vision disorders, increased tears, eye pain, conjunctivitis, accelerated heartbeat, palpitations, drop in blood pressure, rise in blood pressure, tremors, shortness of breath, nosebleeds, increase in liver enzymes in the blood, increased photosensitivity, water retention in the area facial, skin rash, contact dermatitis, back pain, muscle aches, drowsiness.
Rare side effects:
Hypersensitivity, anxiety disorders, increase in intraocular pressure, tinnitus, hypoperfusion of the heart muscle, angina pectoris, laryngeal edema, disorders of blood sugar (hypo or hypo), hematopoietic disorders (reduction in the number of white blood cells, reduction in the number of red Blood corpuscles), muscle stiffness, painful erections lasting more than two hours (priapism).
Very rare side effects:
Short-term unconsciousness (syncope), seizures, hearing impairment.
The use of the drug has led in very rare cases to one-sided blindness. The cause was probably the occlusion of retinal blood vessels. Risk factors for the occurrence of this side effect are hypertension, diabetes mellitus, heart disease, lipid metabolism disorders and smoking. Patients who experience unilateral vision loss should stop taking Vardenafil immediately.
What interactions does Vardenafil show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Anti-fungal agents such as itraconazole and ketoconazole or erythromycin (used to treat bacterial infections) as well as other drugs such as cimetidine or ritonavir (used to treat HIV infection), which also affect liver metabolism, potentiate vardenafil and possibly increase it Frequency of its side effects.
If erythromycin is used concomitantly, the doctor may need to adjust the dose of vardenafil.
HIV-1 protease inhibitors such as ritonavir and indinavir should not be taken concomitantly with vardenafil.
Concomitant use of nitro-based vasodilators or alpha-adrenoceptor antagonists (alpha-sympatholytic agents) results in a mutual enhancement of effect. This can lead to a sharp fall in blood pressure, blood clotting disorders, and an increase in heart rate. These drugs should also not be used together with Vardenafil.
Vardenafil should also not be taken with grapefruit juice. Grapefruit juice prevents the degradation of vardenafil in the body and possibly increases the frequency of its side effects.
The concomitant use of class I antiarrhythmic drugs (eg quinidine, procainamide) or class III antiarrhythmic drugs (eg amiodarone, sotalol) may cause cardiac arrhythmia and should therefore be avoided.
Co-administration of vardenafil and enzyme inducers such as rifamicin, phenobarbital, phenytoin and carbamazepine may reduce the effects of vardenafil.