About Lamictal

3.5 rating based on 52 ratings
Rating: 3.3 Reviews: 52
About Lamictal

Lamotrigine has broad efficacy in epilepsy. Thus simple focal seizures, complex psychomotor seizures, the so-called grand times in various forms and mixed epilepsy forms with lamotrigine as single active substance can be treated well.

What is the purpose of this ingredient?

    • treat different forms of epilepsy
    • prevent epileptic seizures during alcohol withdrawal

Preventing manic-depressive phases in depression

  • relieve pain in migraine and nerve pain such as trigeminal neuralgia
  • Symptoms of Parkinson’s disease and cutaneous ( Huntington’s disease), relieving seizures in the status epilepticus


This is how Lamotrigin works

Below you will learn more about the fields of application and the mode of action of Lamotrigine.
Please also read the information on the drug group antiepileptic drugs,
to which the active ingredient lamotrigine belongs.

Applications of the active ingredient Lamotrigine

Lamotrigine has broad efficacy in epilepsy. Thus simple focal seizures, complex psychomotor seizures, the so-called grand times in various forms and mixed epilepsy forms with lamotrigine as a single active substance can be treated well.

In the so-called Lennox-Gastaut syndrome (a specific childhood seizure of epilepsy), lamotrigine may be used as adjunctive therapy even in children from two to eleven years of age.

Depending on the manufacturer of a drug, lamotrigine is also approved for the treatment of other conditions:

To prevent seizure in alcohol withdrawal. This application may only be done in a hospital.

For the prevention of depression associated with manic-depressive disease syndromes, when lithium therapy has failed or patients should not be treated with lithium.

In addition to these recognized areas of application, there are other medical conditions that can be treated with lamotrigine. It can reduce the symptoms of Parkinson’s disease and chorea (Huntington’s disease), seizures in the epileptic state, and pain in migraine and certain neurological disorders (such as trigeminal neuralgia).

More detailed information is available on the following Lamotrigin application areas:

  • depression
  • epilepsies

Action of Lamotrigine

Lamotrigine is a new generation antiepileptic drug whose chemical structure does not resemble any other member of this group of drugs.

Lamotrigine is very well tolerated compared to other antiepileptic drugs. Therapy discontinuations due to severe side effects are much less common than with other antiepileptic drugs. Lamotrigine hardly makes you tired and does not interfere significantly with the thinking processes, this is beneficial for the patients. Its biggest drawback is the frequent severe intolerance reactions that can occur. By slowly increasing (cradling) the dose, however, these dangerous allergic reactions can be largely avoided.

The mechanism of action of lamotrigine is interesting because it is the first drug to have antiepileptic activity by attenuating stimulating impulses. Lamotrigine prevents the release of the neurotransmitter glutamate, the main neurotransmitter of stimulating impulses. Thus, lamotrigine inhibits the transmission of stimuli. It causes the blockage of long-lasting, repetitive discharges in nerve cells and prevents both the release of glutamate and the excess discharges caused by glutamate.

This effect is achieved by influencing voltage-dependent sodium channels. However, the effect on these channels of sodium is obviously not the same as with phenytoin or carbamazepine, as these drugs do not act primarily via glutamate inhibition.

Furthermore, lamotrigine has a soothing and calming effect as well as antidepressant and muscle relaxant properties. These, as well as the analgesic properties of lamotrigine in nerve pain, are probably due to an inhibition of the transmission of the nerves in the spinal cord.

Potential Lamictal side effects may include:

Lamictal used to treat the following diseases:

  1. Charles M. Wimberly says:
    4.5 rating

    Lamictal for Epilepsy

    I have been taking Keppra 500 for 5 years. In the morning and in the evening, 1500 mg each and Lamictal 200: 200 mg each morning and evening. Side effect I could / could not find any.Bin since seizure-free.

    Side effects: No side effects
  2. Deloris S. Klingensmith says:
    3.5 rating

    Lamictal for Epilepsy

    I have no side effects.This drug is very good! But one should note something very important, with all medications, that one should prescribe the Orginale prescription, because it can lead to drug level fluctuations when taking generic drugs, this is a drug that has the same name, but is not an original drug ie you do not have to pay anything, but unfortunately I have the experience that my drug level so einbstein come because sometimes I was prescribed the original recipe of Lamictal or sometimes a cheaper! And that started backSo watch out that there is always a CROSS on the recipeI was also in Bielefeld Bethel to adjust me, because I recently took Urfiril, which I then had beautiful side effects had hair loss, Fressattaken, was already blatant and combined with Lamictal!

    Side effects: No side effects
  3. Lisa G. Jackson says:
    5.0 rating

    Lamictal for Epilepsy

    Hello ! … after my brain op (sinus edge meningioma) I was prescribed to strengthen the nerve irritation very well dosed Lamictal. Initially 2×25 mg, then 2×50 mg and after about 1 year 2×100 mg. I tolerate this anti-epileptic drug excellent. No side effects. Blood values ok. With the support of this medication and of course changing my lifestyle, mindfulness – listening to my body, the seizures occur 3-4 times a year. (focal Jackson marches without loss of consciousness or change of sensory perception). It cramps my right half of the body, always logs in before. Early warning system. Tingling in the foot or slight numbness in the right arm. Seizure duration between 1 and 5 minutes. Even though I have had these seizures for 4 1/2 years, it brings with it anxiety, discomfort, and depression. Conditional also because he comes when no one is there. This week, a friend has experienced it, it was very instructive for me to experience how combative, strong, I deal with it alone. By the way, there is really educational info on these topics on Wikipedia. We all do well – always think positive and live! Do not let yourself fall, then you just fall deeper.

    Side effects: No side effects
  4. Rhonda A. Keen says:
    4.0 rating

    Lamictal for Epilepsy

    Keppra: nausea, stomach upset, discontinued due to excessive weight loss. Lamictal in the beginning dizziness, blurred vision, nausea, disappeared after a time. Remained: severe fatigue, difficulty concentrating, word finding disorders, muscle twitching Rivotril: just dizzy at the beginning, now no more side effects. Topamax: tingling in the fingers and feet, dizziness at the beginning. But they disappeared again. Loss of appetite, weight loss, sleep disorders.

  5. Irene E. Reynolds says:
    4.0 rating

    Lamictal for Epilepsy

    At the beginning 10kg weight gain, duration of mental fatigue, no ability to concentrate in school conclusion worse grades, strong mood swings, by taking too much lamictal eye problem like eye pressure or something, but was better in low dose. Loss of appetite due to additional intake of Topomax positive effect 22 kg weight loss.