About Lamictal

3.5 rating based on 52 ratings
Rating: 3.3 Reviews: 52
About Lamictal

Lamotrigine has broad efficacy in epilepsy. Thus simple focal seizures, complex psychomotor seizures, the so-called grand times in various forms and mixed epilepsy forms with lamotrigine as single active substance can be treated well.

What is the purpose of this ingredient?

    • treat different forms of epilepsy
    • prevent epileptic seizures during alcohol withdrawal

Preventing manic-depressive phases in depression

  • relieve pain in migraine and nerve pain such as trigeminal neuralgia
  • Symptoms of Parkinson’s disease and cutaneous ( Huntington’s disease), relieving seizures in the status epilepticus


This is how Lamotrigin works

Below you will learn more about the fields of application and the mode of action of Lamotrigine.
Please also read the information on the drug group antiepileptic drugs,
to which the active ingredient lamotrigine belongs.

Applications of the active ingredient Lamotrigine

Lamotrigine has broad efficacy in epilepsy. Thus simple focal seizures, complex psychomotor seizures, the so-called grand times in various forms and mixed epilepsy forms with lamotrigine as a single active substance can be treated well.

In the so-called Lennox-Gastaut syndrome (a specific childhood seizure of epilepsy), lamotrigine may be used as adjunctive therapy even in children from two to eleven years of age.

Depending on the manufacturer of a drug, lamotrigine is also approved for the treatment of other conditions:

To prevent seizure in alcohol withdrawal. This application may only be done in a hospital.

For the prevention of depression associated with manic-depressive disease syndromes, when lithium therapy has failed or patients should not be treated with lithium.

In addition to these recognized areas of application, there are other medical conditions that can be treated with lamotrigine. It can reduce the symptoms of Parkinson’s disease and chorea (Huntington’s disease), seizures in the epileptic state, and pain in migraine and certain neurological disorders (such as trigeminal neuralgia).

More detailed information is available on the following Lamotrigin application areas:

  • depression
  • epilepsies

Action of Lamotrigine

Lamotrigine is a new generation antiepileptic drug whose chemical structure does not resemble any other member of this group of drugs.

Lamotrigine is very well tolerated compared to other antiepileptic drugs. Therapy discontinuations due to severe side effects are much less common than with other antiepileptic drugs. Lamotrigine hardly makes you tired and does not interfere significantly with the thinking processes, this is beneficial for the patients. Its biggest drawback is the frequent severe intolerance reactions that can occur. By slowly increasing (cradling) the dose, however, these dangerous allergic reactions can be largely avoided.

The mechanism of action of lamotrigine is interesting because it is the first drug to have antiepileptic activity by attenuating stimulating impulses. Lamotrigine prevents the release of the neurotransmitter glutamate, the main neurotransmitter of stimulating impulses. Thus, lamotrigine inhibits the transmission of stimuli. It causes the blockage of long-lasting, repetitive discharges in nerve cells and prevents both the release of glutamate and the excess discharges caused by glutamate.

This effect is achieved by influencing voltage-dependent sodium channels. However, the effect on these channels of sodium is obviously not the same as with phenytoin or carbamazepine, as these drugs do not act primarily via glutamate inhibition.

Furthermore, lamotrigine has a soothing and calming effect as well as antidepressant and muscle relaxant properties. These, as well as the analgesic properties of lamotrigine in nerve pain, are probably due to an inhibition of the transmission of the nerves in the spinal cord.

Potential Lamictal side effects may include:

Lamictal used to treat the following diseases:

  1. Jesica W. Askew says:
    1.0 rating

    Lamictal for Bipolar disorder

    I am taking Lamotrigine for 10 days now, no effect. I am very irritated and aggressive, I am depressed and without any drive. Side effect: Loss of appetite.

    Side effects: Anorexia
  2. Teresa T. Boring says:
    3.5 rating

    Lamictal for Sleep disorders; Mood swings; Depression

    abilify: uneasiness, always having to move, insomnia, lack of appetite, easy dizziness, estimating distances is difficult (often running against it) seroquel: taking in the evening against the insomnia (abilify), immediately tired and sleep like in koma deep and insecure, the next day, it’s hardly possible for me to concentrate, no effort to knock out and too tired for everything.

    Side effects: Unrest; Anorexia; Dizziness; Fatigue
  3. Mildred L. Carter says:
    2.5 rating

    Lamictal for Epilepsy

    Fatigue, strong cognitive disorders, such as forgetfulness, word problems, sleep disorders, mood disorders, weight gain. After discontinuing the medications, the side effects were gradually resolved

  4. Wilma O. Loggins says:
    4.0 rating

    Lamictal for Epilepsy

    Daughter gets Lamictal for 2.5 years, approx. 5 seizures per year, 125 – 0-75. If the tablets are turned on in the evening, no one can fall asleep before 1 o’clock at the earliest. Do not get out of bed in the morning, constantly tired, the 6th and 7th school lesson pass by pretty much. Grade average has dropped from 1.8 to 3.3 in 6 months, has to work hard to keep that at least. Memory and concentration greatly reduced: 150% work for 80% result! If she does not sleep at least 1.5 hours after school, she can not even do her homework. Will be switched to another drug in April.

  5. Claudine A. Sterling says:
    3.5 rating

    Lamictal for Epilepsy

    Depakine: It was awful! Weight gain (about 10 – 15 kilos), permanent fatigue (!!), could not get up, Could not express me linguistically – words omitted me, could not articulate me more. Could not learn anymore, did not notice anything anymore (big concentration difficulties), grades were bad, I was getting worse and worse with these things. almost slept and ate more (after the increase ..) The doctor said that it was not because of the medication, but because I had started to study and everything was new to me …. schmafu …. well, then a doctor change! private doctor. Switching to Lamictal – I was suddenly much better, first exam on the uni, note 2, totally great. weight loss, concentration improved again – now I’m really good !!! I can only say: trust your body and do not trust your doctor. I’ve always thought (when I was still small na, they already know what they are doing … that’s not true ….. – long process of cognition =) ok, then good luck people

  6. Gary S. Hill says:
    2.0 rating

    Daily headache from the neck austrahlend over the entire head to the eyes, so the partial thought and language loss occurs. Amount of daily intake & lt; & gt; In the evening before going to bed 2x25mg in tablet form. The pain is similar to a hangover that was called by alcohol.

    Side effects: Headache
  7. Irene G. Dyer says:
    2.0 rating

    Lamictal for Epilepsy

    I currently take Lamictal morning and evening and 100mg each. I have been on this drug for a year, but I have seizures all the time. At the moment I am already very pessimistic, because the drug has no effect. I can not really judge if I would recommend Lamictal or not. I think that it does not show the same effect on everyone. Side effects are unknown to me, except partial headache and tiredness.

    Side effects: Headache; Fatigue
  8. Jonathan M. Peterson says:
    2.5 rating

    Lamictal for Sleep disorders; Depression

    strong nausea, all day. Initially improvement in sleep and sleep – but from the 3rd day no improvement. Swelling of the nasal mucosa – respiratory problems through the nose, weight gain, funny taste in the morning

    Side effects: Nausea; Increase in weight
  9. Amber F. Landaverde says:
    3.0 rating

    Lamictal for Epilepsy

    Trembling hands, tiredness, nightmares, and occasionally problems with circulation in the morning or during stress.

    Side effects: Tremble; Fatigue
  10. Donna M. Harris says:
    3.0 rating

    Lamictal for Epilepsy

    hair loss

    Side effects: Hair loss