About Lamictal

3.5 rating based on 53 ratings
Rating: 3.3 Reviews: 53
About Lamictal

Lamotrigine has broad efficacy in epilepsy. Thus simple focal seizures, complex psychomotor seizures, the so-called grand times in various forms and mixed epilepsy forms with lamotrigine as single active substance can be treated well.

What is the purpose of this ingredient?

    • treat different forms of epilepsy
    • prevent epileptic seizures during alcohol withdrawal

Preventing manic-depressive phases in depression

  • relieve pain in migraine and nerve pain such as trigeminal neuralgia
  • Symptoms of Parkinson’s disease and cutaneous ( Huntington’s disease), relieving seizures in the status epilepticus


This is how Lamotrigin works

Below you will learn more about the fields of application and the mode of action of Lamotrigine.
Please also read the information on the drug group antiepileptic drugs,
to which the active ingredient lamotrigine belongs.

Applications of the active ingredient Lamotrigine

Lamotrigine has broad efficacy in epilepsy. Thus simple focal seizures, complex psychomotor seizures, the so-called grand times in various forms and mixed epilepsy forms with lamotrigine as a single active substance can be treated well.

In the so-called Lennox-Gastaut syndrome (a specific childhood seizure of epilepsy), lamotrigine may be used as adjunctive therapy even in children from two to eleven years of age.

Depending on the manufacturer of a drug, lamotrigine is also approved for the treatment of other conditions:

To prevent seizure in alcohol withdrawal. This application may only be done in a hospital.

For the prevention of depression associated with manic-depressive disease syndromes, when lithium therapy has failed or patients should not be treated with lithium.

In addition to these recognized areas of application, there are other medical conditions that can be treated with lamotrigine. It can reduce the symptoms of Parkinson’s disease and chorea (Huntington’s disease), seizures in the epileptic state, and pain in migraine and certain neurological disorders (such as trigeminal neuralgia).

More detailed information is available on the following Lamotrigin application areas:

  • depression
  • epilepsies

Action of Lamotrigine

Lamotrigine is a new generation antiepileptic drug whose chemical structure does not resemble any other member of this group of drugs.

Lamotrigine is very well tolerated compared to other antiepileptic drugs. Therapy discontinuations due to severe side effects are much less common than with other antiepileptic drugs. Lamotrigine hardly makes you tired and does not interfere significantly with the thinking processes, this is beneficial for the patients. Its biggest drawback is the frequent severe intolerance reactions that can occur. By slowly increasing (cradling) the dose, however, these dangerous allergic reactions can be largely avoided.

The mechanism of action of lamotrigine is interesting because it is the first drug to have antiepileptic activity by attenuating stimulating impulses. Lamotrigine prevents the release of the neurotransmitter glutamate, the main neurotransmitter of stimulating impulses. Thus, lamotrigine inhibits the transmission of stimuli. It causes the blockage of long-lasting, repetitive discharges in nerve cells and prevents both the release of glutamate and the excess discharges caused by glutamate.

This effect is achieved by influencing voltage-dependent sodium channels. However, the effect on these channels of sodium is obviously not the same as with phenytoin or carbamazepine, as these drugs do not act primarily via glutamate inhibition.

Furthermore, lamotrigine has a soothing and calming effect as well as antidepressant and muscle relaxant properties. These, as well as the analgesic properties of lamotrigine in nerve pain, are probably due to an inhibition of the transmission of the nerves in the spinal cord.

Potential Lamictal side effects may include:

Lamictal used to treat the following diseases:

  1. Ruby W. Looney says:
    3.5 rating

    From time to time I feel like I’m no longer part of this world, almost completely standing next to me. then usually followed by heart rate and anxiety. to be afraid but not to know what you are really afraid of. if this really has to do with the drug is questionable …

  2. John T. Warren says:
    4.0 rating

    Lamictal for Epilepsy

    I feel weak but do not know if it comes only from the individual tablets when I tried to sell them are equal to the accrued accrued again. It is everywhere where no alcohol may be drunk what I was wondering was just when I was drink something more that nothing happened with what I have always expected.The accruals come after the op for the most part only in the sleep to the fore what a great advantage ist.mir was said in bonn in the clinic it is a schlappenlappen epilepsie.nun yes others are worse off than i can see them every day at work so i can be satisfied.

  3. Helen D. Mose says:
    4.5 rating

    Lamictal for Depression; Epilepsy

    I took Cipralex for 9 months, 20 mg daily in the morning. Everything was fine in the beginning, I tolerated it very well, my complaints were much better than before. The first side effects were: Weight gain up to 15 Kg in the 9 months, I could not cry anymore, I was so caught up in the drug that I could no longer grief. I was totally tired and exhausted, beaten off, impotent, had no desire for anything, could not get me up to anything. I had a lot of sweats, increased tremors, bad headaches and muscle aches. It was hard for me to get up, I just sat in my room. In May, I discontinued after consultation with my doctor Cipralex. Since then I have increased this Restles Leg syndrome, the so-called restless legs. This soon gets me out of my mind, I can not sleep before one or two o’clock in the morning, have very confused dreams, wake up with sweat. And since I dropped off Cipralex, I’m again very close to the water built, I was very much missing that I can just cry. I do not recommend taking Cipralex for longer than necessary, especially in combination with other psychotropic drugs. The effect can be affected. I can only say that Cipralex helped me very well at the time of the crisis, but after prolonged ingestion, my life has been seriously affected to the detriment. I wish you all that you will recover and live a good and healthy life without Cipralex and all the other psychotropic drugs.

  4. Patricia J. Cochran says:
    2.5 rating

    all medis make unrealistic thoughts on me side effects. react very strongly to all medis. Truxal blew me the lowest dose and I had a circulatory colapse. when deroxat I always had abdominal pain but otherwise ok felt but no effect. and the discontinued was the horrer mega withdrawal. Since I actually want to lead a normal life I would like a medi where I can get pregnant so I switched to zoloft at the beginning was mr kotz could eat bad and a quarter of an hour came down everything back out. Since I zoloft take again more Attaken would like to get away from it unfortunately I have no real doctor at the time since I am out of the clinic I am looking for a take in the ta 100 mg I think the mega much. and I have since zoloft also very stupid thoughts that make me afraid the feeling of being crazy. fucking medis real. Today I just took a half tablet less and let’s see what happens. I’m also afraid that I’ve read a lot that zoloft has brought her to suicide

    Side effects: Withdrawal symptoms; Nausea
  5. Jan P. Lake says:
    3.0 rating

    Lamictal for Sleep disorders; Mood swings; Depression

    So at Trevilor I had quite a circulatory problem at the beginning. I could barely walk, but then disappeared after 2 weeks and my general condition has improved … but when I wanted to sell my medication .. also the Trevilor I got really severe weaning symptoms such as vomiting, headaches, circulatory problems and the depression came again. I’ll take the medicine again now.

    Side effects: Withdrawal symptoms
  6. Hallie J. Kim says:
    4.5 rating

    Lamictal for Epilepsy

    I’ve been taking Lamictal for 10 years now, before that I took Timonil and Leptilan. At Timonil, there were audiobooks once a month (all as seen in the VCR’s search sweep), which disappeared with Lamictal. In Lamictal in recent years after the long-term treatment, concentration disorders, word finding disorders, forgetfulness and severe back pain caused by diagnosed osteoarthritis in the spine on. Yesterday I saw a documentary on television about the addition of aluminum in drugs as an active agent enhancer and the effects. The film totally shocked me, describing the very symptoms I had, the feeling of dementia and the waning bone. I searched the internet for the ingredients of Lamictal and lo and behold, it is aluminum in the drug. The film wrote about how toxic aluminum affects the body and how it can not be excreted. So I am permanently poisoned. I’ll drop the drug as soon as possible and take something else. I can only warn against it. My back pain and stiffness have become unbearable, I can not sit in a position for long, stand or lie down. It hurts like hell. I’m seizure-free with Lamictal, but the side effects are too bad for me. Especially the word finding disorders and the lack of concentration, which has become much stronger through Lamictal. I’m also angry with the doctors I’ve been with and they’ve all said how good Lamictal is and how tolerable it is. I have often wanted a different medication, but I was always advised against it because I am seizure-free and would be so well-adjusted. In addition, I often have depression and delusions, feel persecuted and perceive people as a threat. Also, the muscle twitching described on the package insert I have. However, they did occur before I took Lamictal, then I took Timonil when I had muscle twitching on my face that occurs in stressful situations and has not been resolved to this day.

  7. Jack G. Nance says:
    3.5 rating

    After many years and various medications, lamotrigine was recommended to me, I took it and my burning leg pain was on the decline. Side effects are the following: Back pain, flatulence (in the evening) a little tired, but I hope that this will be a little less. So completely without side effects is probably none of the drugs. M-L. operating room

    Side effects: Flatulence; Fatigue
  8. Dustin L. Ortiz says:
    1.5 rating

    At the beginning I had itching all over my body, I can sleep very badly about 4 hours a day.

    Side effects: Itching
  9. Olga M. Erwin says:
    3.0 rating

    Lamictal for Epilepsy

    slow dosing is laborious, side effects itching! on the whole body, skin rash, skin problems face (scaling skin), well tolerated with almost all drugs, sleep disturbances the first week at each dose, then everything ok, further increase- again all side effects

  10. Dennis E. Bechtol says:
    4.0 rating

    Lamictal for Epilepsy

    About me: I have epilepsy (6 years) originally as a complex-focal seizure and not through Lamictal anymore, but rarely do I have auras. No loss of consciousness. Current DOsis is 200-0-200mg (since 4 years). (Previously Topamax etc. with dangerous side effects, such as kidney stone, renal colic, aphasia.) Recently, I have Lamictal Phlafstörungen, mood swings (manic-depressive), throughout an annoying feeling of happiness, from time to time aggressive, high lipid value (I need GV , Ejaculation, masturbate every day, otherwise I will break). I need MEdi recommendations, against SChaf disorders and too much happiness.

  11. Melodie C. Walker says:
    4.0 rating

    Lamictal for Epilepsy

    Sleep disorders in higher doses. Signs of severe depression with suicidal thoughts taking lamotrigine. Before that no mental disorders. Efficacy for epilepsy good.

  12. Benjamin E. Hummer says:
    2.5 rating

    Lamictal for Epilepsy

    Was 16 years seizure-free until January! Side effect . Tiredness, trembling, diarrhea

    Side effects: Diarrhea; Tremble; Fatigue
  13. Jessie J. Mercier says:
    3.0 rating

    Lamictal for Epilepsy

    When Keppra: tiredness, loss of appetite, diarrhea, mild depression BeimLamictal: impulsive effect, loss of appetite, hyperactivity

  14. Louie P. Bullock says:
    4.0 rating

    Lamictal for Bipolar disorder

    When adjusting (slow increase from 25mg to today 200mg / d) thin chair to diarrhea. That has normalized, however. Trouble falling asleep today & amp; By sleeping. In many cases no restful sleep. Since I take 100mg in the morning and at noon instead of morning and evening, it is a little better, but not good for a long time. This often causes tiredness. Continue listlessness. Overall, the drug seems to reduce the amplitude of the episodes a bit. After all.

    Side effects: Diarrhea; Listlessness; Fatigue
  15. Gary S. Williams says:
    4.0 rating

    Lamictal for Sleep disorders; Mood swings; Depression

    Hello everybody! Within a half an hour, the states of mind often changed from high to high and sad to death. Initially, Lamictal was added carefully here, but unfortunately the conditions did not improve even after two months. The doctor said that Lamictal will only work after a longer time. Therefore a (still) restrained rating. Update follows. I was unable to fall asleep despite 7.5 mg of zopiclone, often pondering for hours, having severe nightmares, and after sleeping for 12 to 14 hours – with many interruptions – I felt so struck that it took me 6 hours to partially recover to leave the house at all. And again and again this eternal brooding, even in the sleep breaks … For four days I have additionally prescribed Seroquel. 25 mg for two days, since then 50 mg each evening. On the first day, I had already taken it right after the doctor’s visit at 16:00 clock. (25mg) I was invited to dinner right after, but got so tired after an hour that I was glad to be back home. I could have gone downstairs right away and would probably have fallen asleep immediately. But I did not want to, because I was afraid that I would wake up at midnight – and begin to brood alone at night … The effect was around 20:00 clock something after, so I decided against 21:00, another tablet ( 25 mg). The effect was the same as previously described. At around 10:00 pm I slept, and surprisingly did not have nightmares, and woke up at 5:20 in the morning. I had a heavy head, which I got away with coffee within an hour. The feeling of dryness in the mouth then became better and better. But I’m really surprised to find that I’m much more thirsty than before. Which leads to the fact that I now drink at least 3 liters a day, which I have never done before! I also had a craving in the morning. I ate breakfast extensively, which I never did before. I’ve been feeling better since then, I woke up again at 6:00 today. I still need my two hours to be really there, but I’ve already had almost two liters of it for breakfast, breakfast, and my mood is much better, almost a little euphoric. I am very curious how it goes on. I will gladly keep you up to date. The side effects last, but are absolutely bearable – and I even like to accept them when I think of the many improvements.

    Side effects: Mouth dryness
  16. Amanda R. Selvidge says:
    3.5 rating

    Lamictal for Epilepsy

    Orfiril rash, dry mouth at the beginning, flatulence. Had to be discontinued because of allergy.

  17. Joann G. Moore says:
    2.0 rating

    Lamictal for Epilepsy

    Since April this year, extreme gastrointestinal problems, abdominal pain, flatulence as well as constipation as well as stay away from the rule and irregular menstrual cycle