About Januvia

3.0 rating based on 15 ratings
Rating: 2.9 Reviews: 15
About Januvia

In patients with type 2 diabetes mellitus, the drug is used to improve glycemic control. Sitagliptin can be used alone or in combination with other oral antidiabetics (metformin, sulfonylureas, glitazones).

What is the purpose of this ingredient?

  • Promote insulin secretion
  • Increase glucose uptake into the tissue
  • Restrict liver glucose production
  • Reduce blood glucose

This is how Sitagliptin works

Below you will learn more about the areas of application and the mode of action of sitagliptin.
Please also read the information on the drug classes of oral antidiabetics, antidiabetics, to which the active ingredient sitagliptin belongs.

Application of the active substance sitagliptin

In patients with type 2 diabetes mellitus, the drug is used to improve glycemic control. Sitagliptin can be used alone or in combination with other oral antidiabetics (metformin, sulfonylureas, glitazones).

Single therapy with sitagliptin is used when the active substance metformin can not be used. In dual therapy, the drug may be used with metformin, a sulfonylurea or a glitazone. Also a triple therapy together with metformin and a glitazone is possible. A prerequisite for the addition of sitagliptin is an inadequate lowering of blood sugar through diet and exercise plus monotherapy with glitazone, metformin, a sulfonylurea or the dual therapy of metformin and sulfonylurea.

Sitagliptin is also approved as adjunctive therapy to insulin in the treatment of patients with type 2 diabetes. This will allow the use of the drug alone or in combination with metformin in addition to insulin if diet and exercise plus a stable dose of insulin and metformin are not enough to lower blood sugar.

For the following application areas of Sitagliptin , in-depth information is available:

  • Type 2 Diabetes Mellitus

How Sitagliptin works

Sitagliptin belongs to a new subgroup of oral antidiabetics called dipeptidyl peptidase inhibitors. The substances of this group inhibit an enzyme that affects the blood concentration of glucose.

The blood sugar level (blood glucose concentration) is controlled by a control circuit in which so-called incretin hormones play a major role. Incretin hormones are released from the intestine into the bloodstream throughout the day and their concentrations increase in response to a meal. When the blood glucose concentration is normal or elevated, the incretin hormones promote the production and release of insulin from the beta cells of the pancreas. More insulin, however, promotes glucose uptake into the tissue. At the same time, the incretins throttle the liver’s glucose production. All effects taken together cause the blood sugar level to drop. These effects of the incretin hormones are glucose-dependent, so that at low blood sugar levels neither a release of insulin nor a reduced glucose production of the liver occurs. Therefore, incretin hormones can not trigger hypoglycaemia.

The activity of the incretin hormones is limited by the enzyme dipeptidyl peptidase. It quickly breaks down the incretins into inactive products. Sitagliptin prevents enzyme-induced degradation of the incretins. By increasing the concentration of active incretin hormones, sitagliptin increases insulin release and lowers blood glucose levels.

In type 2 diabetics, these changes result in lower blood glucose levels both in the fasting state and after meals.

Potential Januvia side effects may include:

Effect
Percentage

11%

11%

11%

8%

Januvia used to treat the following diseases:

  1. Kelly F. Hunter says:
    4.5 rating

    Januvia for Depression

    Unfortunately, I tried to remove Cymbalta, now I feel that it has done me very well before in terms of pain, exhaustion, depression. I thought, sometime yes away, but I think I take it with the agreement of my psychiatrist again. Expensive is the drug, but really great. The compatibility was also very good with me. Sure, in the beginning I had a bit of a headache, but it quickly disappeared. What happened when I had a flu that I did not get up so fast because it strangled me, I’m already doing allergy to this flu with … I can only recommend it for those who are diabetic because it has a balancing effect. Also, one should suffer from hypothyroidism, it helps.Auch in anxiety, as well as with me, because I suffer from asthma! After an accident in 2003, I had a post-traumatic stress disorder that was hard to get rid of, and then depression and anxiety disorders occurred, with personality changes.

  2. Dale A. Blair says:
    2.0 rating

    extreme flatulence and acidification in the stomach and esophagus

    Side effects: Flatulence
  3. Nicole D. Grieve says:
    2.5 rating

    Januvia for Diabetes mellitus type ii

    Rashes, blistering of hands and feet, dry throat, sensation of sensation on hands and feet, itching and watery eyes, stuffy nose, blistering in the mouth and throat, fatigue, swollen eyes

    Side effects: Itching; Fatigue
  4. Robert C. Blanchard says:
    5.0 rating

    Januvia for Diabetes mellitus type ii

    Proper effect came only after about 4 weeks. After a further 3 months, a strong feeling of tiredness arose during the day, which disappeared a few days after discontinuing Januvia. Approximately 2 weeks later try again with Januvia. There were no more side effects. Take Januvia 100 now for 15 months

    Side effects: Fatigue
  5. Mary M. Morales says:
    2.5 rating

    Very strong headache. Duration Itching all over. Very strong sweating with every movement .. Very severe pain in the joints, worst knee, shinbone, ankle. Swollen feet.

    Side effects: Itching; Sweat
  6. Nola A. Holt says:
    3.0 rating

    Januvia for Diabetes mellitus type ii

    A second attempt with the use of Januvia showed that my symptoms reappeared. Strong itching on arms and legs, extreme itching and burning in the intimate area, mucous membrane swelling in the nose and throat, sweating all over. Due to the strong side effects I will stop Januvia immediately.

    Side effects: Itching; Sweat
  7. Carolyn W. Thornton says:
    3.0 rating

    Januvia for High blood pressure; Diabetes mellitus type ii

    Valsacor: Pain in muscles and joints, stomach problems, dizziness, tiredness, difficulty concentrating Lercanidipine: fast pulse, high blood pressure, extreme urine, nausea, pressure in upper abdomen Januvia: joint pain, nausea

    Side effects: Fatigue; Nausea
  8. Ruth J. Kidd says:
    3.5 rating

    Januvia for Diabetes mellitus type ii

    I took metformin once before years ago, at that time I was also sick of it. Now the doc has prescribed me a diabetologist again the same game starts from the beginning, take now an omeprazole. Since I am only 3 months (?) In the treatment of a specialist and am only in 4 weeks see again. I can not make a final judgment here. Only so much of me is always sick of metformin and flatulence. Please contact me again. Can not recommend Met

    Side effects: Flatulence; Nausea
  9. Raymond S. Ross says:
    2.5 rating

    Januvia for Diabetes mellitus type ii

    After 10 days I had to discontinue Actos, bronchitis, onset of sinusitis, nausea, sweating, blurred vision, fatigue, back pain, small edema and Entzuendugen.

    Side effects: Fatigue; Sweat; Nausea
  10. Terri P. Rowland says:
    4.5 rating

    Januvia for Diabetes mellitus type ii

    Blood sugar levels were always too high, could not be adjusted well with other drugs. With Januvia in conjunction with metforms and diet change within days fabulous blood sugar levels. Side effect with me is that the weight reduction is very easy.

    Side effects: No side effects
  11. David E. Weisz says:
    2.5 rating

    Januvia for High blood pressure; Diabetes mellitus type ii

    Other Medicis, Biosoprol, Beta-Blocker Allopurinol, Uric Acid Fuorese40 Kidneys, Inegy Cholesterol, Simvastatin, Blood Fat, Cymbalta Depression Anxiety, Social Vobia, Amitriptyline Anxiety and Panic Attacks

    Side effects: No side effects