What side effects can sitagliptin have?
Below you will find the most important information about possible known side effects of sitagliptin.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
The occurrence of side effects was highly dependent on the combination partner of sitagliptin:
Sitagliptin + Metformin
Common Side Effects:
Uncommon side effects:
drowsiness, diarrhea, upper abdominal pain, blood sugar lowering.
Sitagliptin + a sulfonylurea
Very common side effects:
low blood sugar
Sitagliptin + Metformin + a sulfonylurea
Very common side effects:
Common side effects: constipation.
Sitagliptin + pioglitazone
Common side effects:
Hypo, bloating, water retention in arms and legs.
In addition to the side effects described above, at least five percent of the patients had upper respiratory tract infection and nasopharyngeal inflammation. Less often, there were bony and joint pains and pains in arms and legs.
Following post-marketing introduction, the following additional adverse reactions have been reported with unknown frequency: hypersensitivity reactions including shock, vascular swelling, rash, nettle rash and severe skin conditions including Stevens-Johnson syndrome.
The use of the active substance may increase the risk of developing acute pancreatitis. However, there are so far only hints from the US. In case of nausea and vomiting, loss of appetite and abdominal pain, the use of the drug should be stopped immediately and a doctor should be consulted.
Also, the risk of cancer of the pancreas may be increased by the use of sitagliptin. Signs requiring a doctor’s visit are severe weight loss and jaundice.
In rare cases sitagliptin may cause elevation of liver function (transaminases) or even hepatitis. If signs of side effects occur (tiredness, yellowing of the skin, nausea), seek medical advice immediately.
What are the interactions of sitagliptin?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
So far, clinical studies have not shown any interactions of sitagliptin with other agents that would require a special indication of the dose change. Only cardiac patients who are particularly sensitive to the cardiac glycoside digoxin should be carefully monitored by the doctor in case of joint treatment with sitagliptin and digoxin.