About Janumet

3.5 rating based on 21 ratings
Rating: 3.5 Reviews: 21
About Janumet

In patients with type 2 diabetes mellitus, the drug is used to improve glycemic control. Sitagliptin can be used alone or in combination with other oral antidiabetics (metformin, sulfonylureas, glitazones).

What is the purpose of this ingredient?

  • Promote insulin secretion
  • Increase glucose uptake into the tissue
  • Restrict liver glucose production
  • Reduce blood glucose

This is how Sitagliptin works

Below you will learn more about the areas of application and the mode of action of sitagliptin.
Please also read the information on the drug classes of oral antidiabetics, antidiabetics, to which the active ingredient sitagliptin belongs.

Application of the active substance sitagliptin

In patients with type 2 diabetes mellitus, the drug is used to improve glycemic control. Sitagliptin can be used alone or in combination with other oral antidiabetics (metformin, sulfonylureas, glitazones).

Single therapy with sitagliptin is used when the active substance metformin can not be used. In dual therapy, the drug may be used with metformin, a sulfonylurea or a glitazone. Also a triple therapy together with metformin and a glitazone is possible. A prerequisite for the addition of sitagliptin is an inadequate lowering of blood sugar through diet and exercise plus monotherapy with glitazone, metformin, a sulfonylurea or the dual therapy of metformin and sulfonylurea.

Sitagliptin is also approved as adjunctive therapy to insulin in the treatment of patients with type 2 diabetes. This will allow the use of the drug alone or in combination with metformin in addition to insulin if diet and exercise plus a stable dose of insulin and metformin are not enough to lower blood sugar.

For the following application areas of Sitagliptin , in-depth information is available:

  • Type 2 Diabetes Mellitus

How Sitagliptin works

Sitagliptin belongs to a new subgroup of oral antidiabetics called dipeptidyl peptidase inhibitors. The substances of this group inhibit an enzyme that affects the blood concentration of glucose.

The blood sugar level (blood glucose concentration) is controlled by a control circuit in which so-called incretin hormones play a major role. Incretin hormones are released from the intestine into the bloodstream throughout the day and their concentrations increase in response to a meal. When the blood glucose concentration is normal or elevated, the incretin hormones promote the production and release of insulin from the beta cells of the pancreas. More insulin, however, promotes glucose uptake into the tissue. At the same time, the incretins throttle the liver’s glucose production. All effects taken together cause the blood sugar level to drop. These effects of the incretin hormones are glucose-dependent, so that at low blood sugar levels neither a release of insulin nor a reduced glucose production of the liver occurs. Therefore, incretin hormones can not trigger hypoglycaemia.

The activity of the incretin hormones is limited by the enzyme dipeptidyl peptidase. It quickly breaks down the incretins into inactive products. Sitagliptin prevents enzyme-induced degradation of the incretins. By increasing the concentration of active incretin hormones, sitagliptin increases insulin release and lowers blood glucose levels.

In type 2 diabetics, these changes result in lower blood glucose levels both in the fasting state and after meals.

Potential Janumet side effects may include:

Janumet used to treat the following diseases:

Disease
Percentage
  1. Daniel J. Rigsby says:
    3.0 rating

    Janumet for Diabetes mellitus type ii

    Had set aside for the aviation Avandia and Glucophage to enter the combination Janumet. Values rose. Fasting values before 120-130. At Janumet not more than 180.

    Side effects: No side effects