The following is information on contraindications to the use of propranolol in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).
When should Propranolol not be used?
Propranolol should not be used in the case of hypersensitivity to the active substance or other beta-blockers, cardiac insufficiency, slow heartbeat (resting heartbeat below 50 beats per minute) and low blood pressure (hypotension).
The use is also not recommended for cardiovascular shock or severe cardiac conduction disorders (such as AV block II or III, sinus node syndrome).
The active substance should not be used in severe circulatory disorders of the arms and legs. The same applies to hypersensitivity of the bronchial system (such as asthma).
Propranolol must not be combined with MAO inhibitors for depression. Even with metabolic acidosis (acidosis) the application is prohibited.
Propranolol should be used only with extreme caution and under strict medical control in the case of mild conduction disturbances in the heart (first degree AV block), diabetes mellitus (diabetes mellitus) with sharply fluctuating blood glucose levels or after prolonged severe fasting. Even heavy physical stress, pregnancy and lactation as well as impaired kidney or liver function require special medical care.
This medical precaution is also required in patients with pheochromocytoma and psoriasis, even if it has only occurred in one family member. The same applies to the use of the drug, if ever severe hypersensitivity reactions to a drug have occurred.
What should you watch out for during pregnancy and lactation?
Propranolol should only be used during pregnancy in urgent cases. It can come with the unborn child to the growth delay. In addition premature labor can occur.
The drug should be discontinued 48 to 72 hours before delivery under medical supervision.
The active substance passes into breast milk. Infants should therefore be under medical supervision while breast-feeding.
What should be considered in children?
Propranolol should not be used in children.
Warnings and Precautions
- Kidney function and liver function should be monitored regularly during treatment with the drug.
- Contact lens wearers should be aware of the lacrimation that may be reduced by the drug.
- Diabetes requires regular blood glucose monitoring.
- The drug may cause allergic reactions in isolated cases.
- Before anesthesia, the anesthetist should be informed about the treatment with the drug.
- Treatment with the drug should not be stopped abruptly, but should be “skipped” at a reduced dosage.
- The drug can affect your ability to react in ways that make driving and operating machinery dangerous.
Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.