Herceptin side effects

What side effects can trastuzumab have?

Below you will find the most important information about possible known side effects of trastuzumab.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).

Early Breast Cancer – Common Side Effects:
Joint Pain, Back Pain, Arm Pain, Leg Pain, Muscle Pain, Bone Pain, Shoulder Pain, Chest Wall Pain, Muscle Spasms, Musculoskeletal Pain, Nasopharyngitis, Influenza, Upper Respiratory Tract Infections, Urinary Tract Infections, Runny nose and sinusitis, cystitis, pharyngitis, bronchitis, shingles, fatigue, water retention in arms and legs, fever, weakness, chills, chest pain, flu-like illness, fluid retention, chest pain, diarrhea, nausea and vomiting, abdominal pain, Constipation, upper abdominal pain, indigestion, gastritis, mouth blight, headache, drowsiness, nervous sensation, dizziness, hot flashes, high blood pressure, lymphatic stasis, rash, itching, nail changes, nail diseases, redness, coughing, respiratory problems, Ra pain in the throat, gagging pain, nausea, nosebleeds, nosebleeds, chest pain, insomnia, depression, restlessness, palpitations, myocardial insufficiency, palpitations, cardiac output reduction, weight gain, urinary dysfunction.

Breast cancer with secondary tumors
Very common side effects:
Abdominal pain, weakness, chest pain, chills, fever, headache, pain, diarrhea, nausea and vomiting, joint pain, muscle pain, rash.

Common side effects:
flu-like illness, back pain, infection, neck pain, malaise, hypersensitivity reaction, mastitis, weight loss, blood vessel dilation, cardiac arrhythmias (supraventricular tachyarrhythmia), low blood pressure, myocardial insufficiency, heart muscle disease, palpitations, refusal to eat, constipation, indigestion , Liver pressure, liver sensitivity, dry mouth, hemorrhoids, white blood cell deficiency, skin bleeding, water retention in arms and legs, water retention in tissue, bone pain, leg cramps, arthritis, drowsiness, nervous sensation, drowsiness, high blood pressure, nerve damage in arms and legs, tremors , Anxiety, depression, insomnia, asthma, cough, dyspnoea, epistaxis, pulmonary dysfunction, pharyngitis, runny nose and sinusitis, urinary tract infections, itching, sweating, nailsv Alterations, dry skin, hair loss, acne, rash (blotchy and blister-like), taste change.

Special features:
If trastuzumab is used together with other cytostatics, the type and frequency of side effects can change greatly.

At the beginning of therapy with trastuzumab, the physician should check cardiac function and then check it every three months. If the pumping capacity of the left ventricle falls ten percentage points below the baseline, therapy should be stopped. After treatment, cardiac control must be performed biannually for two years. If the patient has received additional anthracycline with trastuzumab, cardiac function must be checked annually for five years.

What interactions does trastuzumab show?

Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).

No interaction studies were conducted with the active substance. A risk for interactions with simultaneously given drugs can not be excluded.

It should be noted by the physician that concomitant administration of cytotoxic drugs such as anthracyclines and cyclophosphamide may cause cardiac damage. Especially anthracyclines should not be used at the same time.

Patients on concomitant treatment with cancer drugs such as paclitaxel or docetaxel are at an increased risk of developing pneumonia.

Potential Herceptin side effects may include: