About Herceptin

3.5 rating based on 33 ratings
Rating: 3.4 Reviews: 33
About Herceptin

Trastuzumab is a cancer treatment for breast cancer and is used differently in different degrees of disease.

What is the purpose of this ingredient?

  • specifically bind to the cancer cell trait HER2
  • Stop cancer cells from growing

This is how Trastuzumab works

Below you will learn more about the fields of application and the mode of action of trastuzumab.
Please also read the information on the drug groups immune boosting and -decrosing agents, cytostatics, monoclonal antibodies to which the active ingredient trastuzumab belongs.

Applications of the active substance trastuzumab

Trastuzumab is a cancer treatment for breast cancer and is used differently in different degrees of disease.

In the early stages of cancer, trastuzumab is used alone after surgery, radiotherapy or initial chemotherapy. However, the prerequisite is that the binding site HER2 can be detected in the laboratory on the surface of the breast cancer cells. Trastuzumab needs to dock with these in order to take effect. Following the evaluation of new studies, the use of trastuzumab is now also approved for chemotherapy in patients with early detected HER2-positive breast cancer.

Another field of application for trastuzumab is breast cancer, which has already formed secondary tumors (metastases). As an individual therapy, however, the drug is used only after a previous chemotherapy or at. This chemotherapy must have included at least two cytotoxic drugs (from the subgroups of anthracyclines and taxanes), unless this treatment was unsuitable for the patients. In addition, in patients with hormone-sensitive cancer, a previous hormone treatment must be unsuccessful or such a treatment was not suitable for the patient.

If patients have not yet received chemotherapy for their cancer, trastuzumab is used as a combination partner to cytostatic drugs such as paclitaxel and docetaxel.

In postmenopausal women who have not yet received trastuzumab and have a hormone-sensitive breast cancer, trastuzumab can also be used in combination with a so-called anti-estrogen or an aromatase inhibitor such as anastrozole.

Trastuzumab is also being used to treat cancers (adenocarcinomas) associated with gastric malignancies and the esophageal junction in patients who have not previously received cancer treatment for their disease. Again, the precondition is that the cancer cells have the HER2 binding site. Trastuzumab is used in combination with other cytotoxic drugs such as capecitabine or 5-fluorouracil and cisplatin.

For the following application areas of Trastuzumab , in-depth information is available:

  • breast cancer
  • Cancer (general)

Mode of action of trastuzumab

Trastuzumab is one of the largest group of immunological drugs. More specifically, trastuzumab is a recombinant humanized IgG1 monoclonal antibody against human epidermal growth factor 2 (HER2).

Antibodies are proteins that are actively involved in the body’s defense. Monoclonal antibodies are artificially produced and produced by a cell line derived from a single B lymphocyte (a special form of white blood cells). These monoclonal antibodies bind specifically to a single, unique protein structure on the surface of other cells. In the case of trastuzumab, this is the human epidermal growth factor 2 (HER2), which is produced by 20 to 30 percent of breast cancers and also some cancer cells at the stomach or esophagus junction and is characterized by a particularly rapid course of the disease.</p >

Both in the test tube and in animal experiments, trastuzumab has been shown to inhibit both the growth and proliferation of human cancer cells that produce HER2. In addition, trastuzumab highly effectively marks these cancer cells so that they can be better recognized and destroyed by the body’s own defense.

Potential Herceptin side effects may include:

Herceptin used to treat the following diseases:

Disease
Percentage
  1. Darlene J. Corbett says:
    4.0 rating

    Herceptin for Breast cancer

    occasionally nausea about 1/2 hour after eating, fast fatigue, itching of the skin, chemo stopped 8 weeks ago and so far no hair growth, even at low load breathlessness.

  2. Mabel J. Marshall says:
    4.0 rating

    Herceptin for Breast cancer

    I am suffering from breast cancer for the second time in Sept / 2007 / my chest was taken off / then a very strong chemo with taxane / I was very bad / then radiation / from January 2008 Arimidex Tbl and from March 2008 every 3 weeks Infection with Herceptin / my hair didn’t want to grow again, I’ve gained about 5 kilograms / pain in all joints, muscles, back pain, water retention, hot flashes, vaginal dryness, no desire for sex, joint stiffness at any time of day or night, forgetfulness, difficulty concentrating and I’m sure still what to forget;)) try – partly with good success – through sports (walking, stretching exercises) to improve my quality of life.

  3. Maria M. Ros says:
    3.5 rating

    Herceptin for Breast cancer

    Bone disorders, chest pain in the ribs, muscular complaints, tingling in the hands, joint stiffness, anxiety, hot flashes, fingernail fragility, blackening of the fingers and toenails, hair loss, depression, insomnia, musculoskeletal pain, vaginal dryness, listlessness, weight gain

  4. Olevia M. Hoff says:
    4.5 rating

    Herceptin for Breast cancer

    Since August I get every three weeks Herceptin. Since that time, I have noticed that my knees and fingers become stiffer, especially in the morning and when I am sitting for a long time. Also, the joints are very painful. Also certain muscle pain in the sub and / or. Upper arm occur. A general weakness of the muscles has also occurred to me.

  5. Ofelia G. Jaramillo says:
    4.5 rating

    Herceptin for Breast cancer

    brittle fingernails, 10kg weight gain, severe fatigue and weakness, balance disorders, muscle weakness. Diagnosis Dec. 2005 Followed by June 2006 Chemo, Op. July 2006, followed by 28 exposures, then 1 year 3 weekly Herceptin. The balance disorders and muscle weakness occurred only after the end of the therapy.

  6. Bessie D. Wade says:
    4.5 rating

    Herceptin for Breast cancer

    Suffering from breast cancer in May 2008, breast conserving surgery, then 6x chemo and 37x radiation. Everything over well. Chemo with side effects, but not as bad as always is told, irradiation without side effects. Herceptin every 3 weeks with fingernail fragility and tiredness as well as bone pain and mood swings, but everything is also bearable. Without this therapy we would be worse off. I can only say to all women, do not lose heart, then everything will be fine. \

  7. Windy C. Gonzalez says:
    3.0 rating

    Herceptin for Breast cancer

    I have received Herceptin every 3 weeks so far, exactly 7-8 days later the symptoms started. Mucous membranes in the mouth associated with difusen toothache and pustules in the mouth and vagina, bone pain, shortness of breath and Brustbeklemmung, after eating stomach pain, often sleepless, sometimes strong back pain. My dose has now been reduced and I get the infusion every week, hoping that the side effects will be less

  8. Mary J. Cassidy says:
    3.0 rating

    Herceptin for Breast cancer

    By Tamoxifen, unfortunately, I have also increased (: (Ca.4 kilos (but the sport helps me to keep my weight now!) Side effects of tamoxifen: extreme hot flashes / weight gain Side effects Herceptin: Tiredness / Canceled on the day of infusion / frost states / Mental Tension and slight nausea in the first two hours after infusion Side effects Zometa: Bone pain / fever 38.7 degrees, however, get back to grips after taking 2 acetaminophen pieces.