About Gabapentin

3.0 rating based on 107 ratings
Rating: 3.1 Reviews: 107
About Gabapentin

Gabapentin is used in adults and children over the age of twelve, who suffer from epilepsy that affects only part of the brain, that is, has a so-called focal origin (also called focal seizures). Seizures that spread from one point in the brain (“focus”) to the entire brain later (so-called secondary generalized seizures) can also be treated with gabapentin. For this purpose gabapentin can also be combined with other antiepileptic drugs. These combinations are already suitable for use in children over the age of three years.

What is the purpose of this ingredient?

  • Reduce overexcitability of nerve cells
  • Increase seizure threshold
  • treat certain nerve pain like diabetic neuropathy
  • treat epilepsy
  • Prevent epileptic seizures
  • Improve tremors without organic cause (essential tremor)

This is how Gabapentin works

Below you will learn more about the fields of application and the mode of action of gabapentin.
Please also read the information on the drug group antiepileptic drugs,
to which the active ingredient gabapentin belongs.

Areas of application of the active substance gabapentin

Gabapentin is used in adults and children over the age of twelve who suffer from epilepsy that affects only part of the brain, that is, has a so-called focal origin (also called focal seizures). Seizures that spread from one point in the brain (“focus”) to the entire brain later (so-called secondary generalized seizures) can also be treated with gabapentin. For this purpose gabapentin can also be combined with other antiepileptic drugs. These combinations are already suitable for use in children over the age of three years.

Gabapentin is also effective against certain adult neuralgia such as diabetic neuropathy, postherpetic neuropathy and others.

Some other diseases are also occasionally treated with gabapentin. However, these indications are not covered by clinical studies and the active substance is not approved. These include certain pains (for example, facial muscle pain), degeneration and damage to nerves (amyotrophic lateral sclerosis), complications of multiple sclerosis (trigeminal neuralgia, painful cramps and others), balance disorders with tremor, tremor, tremor without organic cause (essential tremor) or the Status epilepticus, which does not respond to other antiepileptic drugs.

For the following application areas of Gabapentin , in-depth information is available:

  • epilepsies
  • Pain (mild to moderate)

How gabapentin works

The mechanism of action of gabapentin is not yet well known. Its chemical structure is similar to gamma-amino butyric acid (GABA), an important inhibitory messenger between neurons. Nevertheless, it does not bind to the corresponding binding sites in the brain like the body’s own GABA and prevents the transmission of stimuli there. Rather, the effect seems to come about indirectly because more of the body’s own GABA is being produced. This then exerts the stimulus inhibition. It is further suspected that an influence on the metabolism of other endogenous neurotransmitters, but evidence is still pending.

Gabapentin is not effective in atrial (primary) generalized seizures, such as absences. It can even worsen this type of seizure. Its advantage is the good compatibility compared to other antiepileptic drugs. Also, gabapentin has little adverse effects on concentration, wakefulness and responsiveness.

Potential Gabapentin side effects may include:

Gabapentin used to treat the following diseases:

  1. Janie J. Fredericksen says:
    2.0 rating

    No side effects, positive effect on neuropathic pain symptoms in the transition to paralysis and in the legs

    Side effects: No side effects
  2. Paula J. Lipscomb says:
    3.5 rating

    Gabapentin for Arthrosis; Fibromyalgia; Muscle cramps; Disc prolapse

    Dose-dependent fatigue when gabapentin is overdosed. The combination of the preparations helps me very well, finally I am free of the chronic pain.

    Side effects: Fatigue