About Gabapentin

3.0 rating based on 107 ratings
Rating: 3.1 Reviews: 107
About Gabapentin

Gabapentin is used in adults and children over the age of twelve, who suffer from epilepsy that affects only part of the brain, that is, has a so-called focal origin (also called focal seizures). Seizures that spread from one point in the brain (“focus”) to the entire brain later (so-called secondary generalized seizures) can also be treated with gabapentin. For this purpose gabapentin can also be combined with other antiepileptic drugs. These combinations are already suitable for use in children over the age of three years.

What is the purpose of this ingredient?

  • Reduce overexcitability of nerve cells
  • Increase seizure threshold
  • treat certain nerve pain like diabetic neuropathy
  • treat epilepsy
  • Prevent epileptic seizures
  • Improve tremors without organic cause (essential tremor)

This is how Gabapentin works

Below you will learn more about the fields of application and the mode of action of gabapentin.
Please also read the information on the drug group antiepileptic drugs,
to which the active ingredient gabapentin belongs.

Areas of application of the active substance gabapentin

Gabapentin is used in adults and children over the age of twelve who suffer from epilepsy that affects only part of the brain, that is, has a so-called focal origin (also called focal seizures). Seizures that spread from one point in the brain (“focus”) to the entire brain later (so-called secondary generalized seizures) can also be treated with gabapentin. For this purpose gabapentin can also be combined with other antiepileptic drugs. These combinations are already suitable for use in children over the age of three years.

Gabapentin is also effective against certain adult neuralgia such as diabetic neuropathy, postherpetic neuropathy and others.

Some other diseases are also occasionally treated with gabapentin. However, these indications are not covered by clinical studies and the active substance is not approved. These include certain pains (for example, facial muscle pain), degeneration and damage to nerves (amyotrophic lateral sclerosis), complications of multiple sclerosis (trigeminal neuralgia, painful cramps and others), balance disorders with tremor, tremor, tremor without organic cause (essential tremor) or the Status epilepticus, which does not respond to other antiepileptic drugs.

For the following application areas of Gabapentin , in-depth information is available:

  • epilepsies
  • Pain (mild to moderate)

How gabapentin works

The mechanism of action of gabapentin is not yet well known. Its chemical structure is similar to gamma-amino butyric acid (GABA), an important inhibitory messenger between neurons. Nevertheless, it does not bind to the corresponding binding sites in the brain like the body’s own GABA and prevents the transmission of stimuli there. Rather, the effect seems to come about indirectly because more of the body’s own GABA is being produced. This then exerts the stimulus inhibition. It is further suspected that an influence on the metabolism of other endogenous neurotransmitters, but evidence is still pending.

Gabapentin is not effective in atrial (primary) generalized seizures, such as absences. It can even worsen this type of seizure. Its advantage is the good compatibility compared to other antiepileptic drugs. Also, gabapentin has little adverse effects on concentration, wakefulness and responsiveness.

Potential Gabapentin side effects may include:

Gabapentin used to treat the following diseases:

  1. Kristen T. McLeod says:
    4.5 rating

    Gabapentin for Pain (joint); Pain (back); Neuralgia

    I have had coccyxitis for half a year now. After the orthopedist had injected me three times specifically to the relevant site, and I had felt no improvement, I was referred to the pain therapist. It had already come in the past three years at intervals of about 1/2 year repeatedly to a coccyx inflammation, which, however, with appropriate syringes (1-2 syringes) administered by the orthopedist had passed again. But this time it was so bad that when I was sitting I only had a lot of pain, which went down to the buttocks and usually there was still a burning pain. Television was only possible in the lying, and then laterally best. I had to delete my beloved cycling altogether. Driving was also torture. The pain therapist also tried it with deliberately placed syringes, and in addition he prescribed me on my first visit Katadolon S long, of which I should take 1 whole tabl. It showed no effect for the first 14 days. On my next visit after 2 weeks, I got some injections again, but this time below. The doctor dismissed me again with the recommendation to take the Katadolon S long every evening. Two weeks later I had to tell the doctor that the treatment had been as good as unsuccessful again. Only great fatigue had invaded me after taking Katadolon, so I fell asleep regularly in the TV chair shortly thereafter. Probably that was too much, 1 whole tabl. Katadolon and 1 tabl. Gabapentin. For this I have to mention that for all my medications I still take gabapentin 300 three times a day because of my occipital neuralgia and joint and back pain. Now I have the doctor prescribed the following medication, I call it here drug cocktail: morning: Blutdrucktabl., Gabapentin, 1/2 Tabl. Tramagit 100 retard at noon: Gabapentin, 1/2 Tabl.Katadolon S long evenings: gabapentin, 1/2 tabl Tramagit 100 retard at bedtime: Doxepin 25 mg after 3 weeks Ingestion of this cocktail: improvement in sight, but not yet well, can cycle again, but then has to take a whole pill of tramagit in the evening. (The doctor has allowed me) The greatest effect, I think, comes from this special composition, especially the addition of Tramagit. At most I feel a slight tiredness, which, however, only noticeable in the evening. In 4 weeks now I have an appointment with the pain therapist again. Most of my hope is Tramagit. It is important in a tailbone ignition, so I have found that you always sit very soft. I take my special soft pillow everywhere. Summary: In gabapentin no side effects except increased appetite and thereby gaining weight, therefore eat consciously! 1 whole tablet Katadolon S long: great tiredness, possibly because taken at the same time with gabapentin, 1/2 tabl. Katadolon S long at noon is okay. Tramagit 100 mg retard twice daily 1/2 tablet: No side effects Doxepin 25: 1 tablet taken at bedtime, side effects can not be assessed. Fall asleep quickly

    Side effects: Appetite increase; Fatigue
  2. William S. Rivera says:
    3.5 rating

    Gabapentin for Nerve damage

    I have breathing difficulties, can not breathe for a short time even when drinking can not swallow then.

    Side effects: Respiratory complaints
  3. Catherine A. Baxter says:
    3.0 rating

    Gabapentin for Pain (acute)

    After a few days, there were occasional short pains in the left chest. Now, after a week of pressure, stinging and bad breath in the heart. It became unbearable and it feels threatening

    Side effects: Respiratory complaints
  4. Mckinley B. Hall says:
    4.0 rating

    Gabapentin for Pain (acute)

    I got this drug from my neurologist to treat right leg pain. This is due to a stroke. This dose of 3 times 300 mg a day. The success was zero after 1 month. But the side effect was impotence and incontinence. But can fall asleep well and must be woken in the morning, because otherwise I can always continue to sleep.

    Side effects: Erectile dysfunction
  5. Yong R. Anderson says:
    3.0 rating

    Gabapentin for Neuropathy; Pain (chronic)

    Has been prescribed for nasal pain (chronic) after BS OP in addition to tilidine. initially 1-3 days 1xtgl. 300 mg good action against pain, only mild tiredness 4-13 day 2xtgl. 300 mg good action against nerve pain, water retention, urgency, joint pain 14-20 day 1xtgl. 300 mg good effect against nerve pain, side effects w.o. Overall, a good drug, in terms of benefits / side effects must be weighed individually as always.

  6. Florence J. Pittard says:
    4.0 rating

    Gabapentin for Sleep disorders; Pain (chronic)

    I am a border liner and have been in inpatient treatment for a very long time. In addition, I have chronic pain since a herpes zoster disease. I take: 150 saroten, 10000 gabapentin (I know that is a lot, actually, the maximum dose would be fixed at 3700) 150 Voltaren dispers, 400 Tramal, 300 Seroquel, 15 Zopiclone, 2 Pantozol … this is my solid medication, need medicine (eg Tavor) not included. All these medicines now cause me extreme stomach pains – I’ve had stomach ulcers a few years ago. Especially the Volatren and probably the Gabapentin also go to my stomach. But since I take it for a very long time and there are really many different tablets, I can not say exactly. From the Seroquel I have extremely increased, but need it for rest on the evening. Zopiclone is an indispensable sleeping drug for me, but when I try to leave it out I realize that I get withdrawal symptoms, not surprising after the years of taking in. However, I did not have to dose it high, I take the 2 tablets constantly and can therefore sleep relatively well. Saroten has also caused me to gain weight. The advantage is that I am a little sedated with the help of the Saroten during the day and so calmed down.

  7. Paul S. Lewis says:
    4.5 rating

    Gabapentin for Phantom pain

    Gabapentin: After an initial dosage of 3x200mg I am now at 3x400mg. The side effects are meanwhile low in my case. In the beginning of the intake were the side effect: dizziness; restlessness; Potency problems; Get along well with the drug and can also recommend it. Cymbalta: should replace gabapentin on a trial basis, were recommended by several doctors great disaster, no effect on the pain, many side effects: dry mouth, nausea, sweating, poor sleep, impotence, urinary behavior, ear noise canceled again after 10 days

  8. Norman L. Kim says:
    4.5 rating

    Since 2006 I am suffering from tension and nerve pain in the left arm, in the left leg to both feet. When walking, I have the feeling as if I’m going on raw meat. In addition, I have strong muscle tension in the cervical and lumbar spine. I have already tried different treatments and medicines. Now I take Gabapentin 3 times a day for about 14 days. 300 mg. The success has so far failed, however, the side effects have promptly adjusted. I am constantly tired, listless, tingling in the legs, dizziness, constipation and potency disorders are announced. My quality of life is lowered by 50%. Since today I have withdrawn after Rücksrache with my doctor the drug.

  9. Laura M. Howes says:
    4.5 rating

    Gabapentin for High blood pressure; Rls; Polyneuropathie

    Since I take so many different medications, I can not describe the effect exactly. All I can say is that in the morning, in the evening or at night, I have constant tingling in both feet, burning in my legs, cramps in my calves, toes, feet. I can sleep about 3-4 hours at night, unfortunately not possible for a long time and this is also noticeable on my nervous system. Unfortunately, the doctors have tried everything, but no success. Sometimes it is unbearable.

    Side effects: Sleeping problems
  10. Arthur K. Wilson says:
    3.5 rating

    Gabapentin for Nerve damage

    The side effect of Palladone 16 mg is that I got constipation but it is half as bad. The gabapentin 300 mg is so with the side effect that I have a microsleep and sometimes a little bit dizzy and am also very tired.

  11. Leonarda S. Johnson says:
    4.0 rating

    Gabapentin for Neuropathy

    The sole use of gabapentin after the second operation (middle-hand fracture on the right with postoperative chronic neuropathic pain), initially high-dose at that time, caused me great difficulties. I got severe acne, flooded and was restricted in the reaction, the ability to think and to remember. Likewise, the rather rare but very unpleasant microsleep occurred to me. Then I got Targin prescribed to greatly reduce gabapentin. I’m fine with it, the pain is almost gone. From the prognosis, I try to reduce further, of withdrawal symptoms that affect me, I can not report.

  12. Sharon J. Phillips says:
    4.5 rating

    Katadolon S Long 400mg: Speech stammering, dizziness, tremor Effect: Helps me in the evening better to fall asleep and the night better to cope with the pain in the back. I take the side effects into account. Gabapentin 1A Pharma 300mg: Extremely water storage Effect: The pain in the nerves is corrected quite well from Table 1 – 10 about 5 so I was satisfied but the water retention and weight gain were too strong. Once Lyrica about 1/2 year taking duration, at 2. times after 10 days the same side effects, therefore discontinued. Morphine: At the beginning of therapy extreme microsleep therefore about 1 year no car driving but after getting used to that went again. Effect: The pain is storable and I can cope with it.