About Gabapentin

3.0 rating based on 105 ratings
Rating: 3.1 Reviews: 105
About Gabapentin

Gabapentin is used in adults and children over the age of twelve, who suffer from epilepsy that affects only part of the brain, that is, has a so-called focal origin (also called focal seizures). Seizures that spread from one point in the brain (“focus”) to the entire brain later (so-called secondary generalized seizures) can also be treated with gabapentin. For this purpose gabapentin can also be combined with other antiepileptic drugs. These combinations are already suitable for use in children over the age of three years.

What is the purpose of this ingredient?

  • Reduce overexcitability of nerve cells
  • Increase seizure threshold
  • treat certain nerve pain like diabetic neuropathy
  • treat epilepsy
  • Prevent epileptic seizures
  • Improve tremors without organic cause (essential tremor)

This is how Gabapentin works

Below you will learn more about the fields of application and the mode of action of gabapentin.
Please also read the information on the drug group antiepileptic drugs,
to which the active ingredient gabapentin belongs.

Areas of application of the active substance gabapentin

Gabapentin is used in adults and children over the age of twelve who suffer from epilepsy that affects only part of the brain, that is, has a so-called focal origin (also called focal seizures). Seizures that spread from one point in the brain (“focus”) to the entire brain later (so-called secondary generalized seizures) can also be treated with gabapentin. For this purpose gabapentin can also be combined with other antiepileptic drugs. These combinations are already suitable for use in children over the age of three years.

Gabapentin is also effective against certain adult neuralgia such as diabetic neuropathy, postherpetic neuropathy and others.

Some other diseases are also occasionally treated with gabapentin. However, these indications are not covered by clinical studies and the active substance is not approved. These include certain pains (for example, facial muscle pain), degeneration and damage to nerves (amyotrophic lateral sclerosis), complications of multiple sclerosis (trigeminal neuralgia, painful cramps and others), balance disorders with tremor, tremor, tremor without organic cause (essential tremor) or the Status epilepticus, which does not respond to other antiepileptic drugs.

For the following application areas of Gabapentin , in-depth information is available:

  • epilepsies
  • Pain (mild to moderate)

How gabapentin works

The mechanism of action of gabapentin is not yet well known. Its chemical structure is similar to gamma-amino butyric acid (GABA), an important inhibitory messenger between neurons. Nevertheless, it does not bind to the corresponding binding sites in the brain like the body’s own GABA and prevents the transmission of stimuli there. Rather, the effect seems to come about indirectly because more of the body’s own GABA is being produced. This then exerts the stimulus inhibition. It is further suspected that an influence on the metabolism of other endogenous neurotransmitters, but evidence is still pending.

Gabapentin is not effective in atrial (primary) generalized seizures, such as absences. It can even worsen this type of seizure. Its advantage is the good compatibility compared to other antiepileptic drugs. Also, gabapentin has little adverse effects on concentration, wakefulness and responsiveness.

Potential Gabapentin side effects may include:

Gabapentin used to treat the following diseases:

  1. William S. Rivera says:
    3.5 rating

    Gabapentin for Nerve damage

    I have breathing difficulties, can not breathe for a short time even when drinking can not swallow then.

    Side effects: Respiratory complaints
  2. Kristen T. McLeod says:
    4.5 rating

    Gabapentin for Pain (joint); Pain (back); Neuralgia

    I have had coccyxitis for half a year now. After the orthopedist had injected me three times specifically to the relevant site, and I had felt no improvement, I was referred to the pain therapist. It had already come in the past three years at intervals of about 1/2 year repeatedly to a coccyx inflammation, which, however, with appropriate syringes (1-2 syringes) administered by the orthopedist had passed again. But this time it was so bad that when I was sitting I only had a lot of pain, which went down to the buttocks and usually there was still a burning pain. Television was only possible in the lying, and then laterally best. I had to delete my beloved cycling altogether. Driving was also torture. The pain therapist also tried it with deliberately placed syringes, and in addition he prescribed me on my first visit Katadolon S long, of which I should take 1 whole tabl. It showed no effect for the first 14 days. On my next visit after 2 weeks, I got some injections again, but this time below. The doctor dismissed me again with the recommendation to take the Katadolon S long every evening. Two weeks later I had to tell the doctor that the treatment had been as good as unsuccessful again. Only great fatigue had invaded me after taking Katadolon, so I fell asleep regularly in the TV chair shortly thereafter. Probably that was too much, 1 whole tabl. Katadolon and 1 tabl. Gabapentin. For this I have to mention that for all my medications I still take gabapentin 300 three times a day because of my occipital neuralgia and joint and back pain. Now I have the doctor prescribed the following medication, I call it here drug cocktail: morning: Blutdrucktabl., Gabapentin, 1/2 Tabl. Tramagit 100 retard at noon: Gabapentin, 1/2 Tabl.Katadolon S long evenings: gabapentin, 1/2 tabl Tramagit 100 retard at bedtime: Doxepin 25 mg after 3 weeks Ingestion of this cocktail: improvement in sight, but not yet well, can cycle again, but then has to take a whole pill of tramagit in the evening. (The doctor has allowed me) The greatest effect, I think, comes from this special composition, especially the addition of Tramagit. At most I feel a slight tiredness, which, however, only noticeable in the evening. In 4 weeks now I have an appointment with the pain therapist again. Most of my hope is Tramagit. It is important in a tailbone ignition, so I have found that you always sit very soft. I take my special soft pillow everywhere. Summary: In gabapentin no side effects except increased appetite and thereby gaining weight, therefore eat consciously! 1 whole tablet Katadolon S long: great tiredness, possibly because taken at the same time with gabapentin, 1/2 tabl. Katadolon S long at noon is okay. Tramagit 100 mg retard twice daily 1/2 tablet: No side effects Doxepin 25: 1 tablet taken at bedtime, side effects can not be assessed. Fall asleep quickly

    Side effects: Appetite increase; Fatigue
  3. John C. Shoffner says:
    5.0 rating

    Gabapentin for Rls

    Obtained by the neurologist Gabapentin against my RLS (light form) prescribed mainly to get a good night’s sleep. Since gabapentin is a centrally acting agent, the associated side effects such as fatigue and difficulty concentrating, in addition to increased appetite and resulting weight gain, that’s actually the problem. Despite evening dosing of 100mg, the following day is very slow / sluggish. One has the feeling, mentally and physically, to drive with the handbrake on. The RLS symptoms are of course also muted. I will talk again with my neurologist about alternatives.

  4. Harry E. Pratt says:
    2.0 rating

    Gabapentin for Muscle cramps

    The cramps became a little easier, in addition and reached joint and ball of the right hand. The right foot is severely affected by the pain, vertebrae 4.5 and lower pelvic pain – applying Flector EP

    Side effects: No side effects
  5. Joseph G. Barnett says:
    4.0 rating

    Gabapentin for Morbus sudeck

    In the beginning often nausea, dizziness, now in vehicles or faster movements. Lack of concentration, blurred vision and mild to moderate skin eczema. Tiredness (however, the fatigue was greater when the dose was lowered temporarily, presumably it is also painful). Weight gain, but by consistently less controllable. Decreased libido. Dose 3000mg / d

  6. Tonya G. Watts says:
    2.5 rating

    Gabapentin for Morbus sudeck

    I have morbus Sudeck on the right hand. 2 years ago we had a car accident, while my wrist is broken. The tablet gabapentin sometimes causes me problems, i. I have hair loss and my memory has diminished. My life, I can say, has totally changed. Greeting Barbara

    Side effects: Hair loss
  7. Hattie D. Faulk says:
    3.5 rating

    Gabapentin for Multiple sclerosis; Pain (acute)

    I’ve had Ms since 1991 and in recent years the pain in my feet and legs has become unbearable. Feeling like being trapped in a vise and someone keeps turning. Initially, gabapentin was quite severe (dizziness, fatigue, word problems). In the meantime I take 2×600 mg in the evening and if necessary also 1-2x 600mg during the day. I’m tired of gabapentin, but I still can not sleep. I’ve gained weight if I skip the medication (because I want to drive a car over longer distances, for example), then I can def. not sleep. Vermutl. slight withdrawal symptom. Sexual desire has also declined significantly – but could also be due to the disease. Still, I would recommend gabapentin for such pain. Better to take something for the pain than to torture yourself all day. Oh well, if I move after taking (walk around or brush), then it does not work. In the meantime, medication only works for me after three or more hours. Taking today for example at 10 pm I am still sitting here and we have 2 pm!

  8. Sandra E. Rodriguez says:
    3.5 rating

    Gabapentin for Multiple sclerosis

    After an initial side effect in the form of a flu-like disorder, there are now NO side effects. To what extent Betaferon actually helps me, I can not judge. I have not noticed any change since my first (very long-lasting) push two years ago. The basic examinations at the doctor consultations of my neurologist at regular (4-6-weekly) intervals, show no change / worsening of my state of health. Pain of the entire gait apparatus burdened me by an inborn hip diploma bds and the associated scoliosis for many years. These can be mixed with Diclofenac 75 and z.T. mitigate with gabapentin.

  9. Ronald A. Rodriquez says:
    3.0 rating

    Gabapentin for Sleep disorders; Disc prolapse; Pain (chronic)

    When morphine I have no problems with the conversion. By lyrica on gabapentin, however, strong conversion problems. Exclusion and pustules on the skin, associated with itching. Syneudon after taking a strong feeling of fatigue and in the morning a very strong tongue.

    Side effects: Fatigue
  10. John A. Landrum says:
    2.5 rating

    Gabapentin for Sleep disorders

    I took this medication for my constant insomnia and severe restlessness in the dialysis chair, it was particularly bad here because I am not very mobile during dialysis, here I have tried to compensate for this tremendous inner rest pressure by constantly moving the legs, which unfortunately did not work. The physical strain was enormous, the pressure barely sustainable, and it sometimes happened that I stopped dialysis to run back and forth in the corridor. Now I have another appointment with a specialist to try to solve my problems.

    Side effects: No side effects
  11. Diana J. Johnson says:
    2.5 rating

    Gabapentin for A headache

    I have no headaches, just pressure in the head and on the right eye, as well as disability in the right arm and in the hand

  12. Paige M. Malcolm says:
    3.5 rating

    Gabapentin for Borreliose

    Weight gain, Dizzy, Irritable, Depressed !!! 1st drug: mefenabene 500mg (17 days) 2nd drug: OSPEN 1500mg (10 days) positive borreliosis TEST I. Lumbar puncture 3rd drug: doxycycline 3x daily 100mg II. Lumbar puncture 4th drug: ceftriaxone 2g liquid (infusions 3 weeks) 5. Medication: ibuprofen 600mg (3x daily 1 week) 6. Medication: Cabapentin 300mg (4x daily 4th week) + 5kg, food cravings

  13. Linda K. Rodriquez says:
    3.5 rating

    Gabapentin for Borreliose; Neuropathy

    because I was prescribed this drug too high doses, I got syncopal attacks. I was about 8 times a day unconscious, had memory and memory disorders and doctors told me, my attacks were very life-threatening!

  14. Charles R. Densmore says:
    4.0 rating

    Gabapentin for High blood pressure; Rls

    Of the 10 different medications I take, only 3 are associated with side effects. Gabapentin: constipation u. Increase in weight Ramiclair: Increase in blood sugar level (long-term value) Tramal: At first, nausea

  15. Jennifer J. Watson says:
    2.5 rating

    Gabapentin for Arthrosis

    Constant fatigue, big weight gain (in 2 years 25 kg) without eating more or different

    Side effects: Increase in weight; Fatigue