About Forxiga

3.5 rating based on 12 ratings
Rating: 3.7 Reviews: 12
About Forxiga

Forxiga is the only inhibitor of sodium-glucose-cotransporter type 2 (SGLT-2) with proven efficacy and safety for 4 years of use. One tablet a day, regardless of food intake, ensures a stable decrease in blood pressure, a significant and persistent decrease in glycated hemoglobin, a steady decrease in body weight. The drug is not indicated for the treatment of obesity and hypertension. The results were secondary endpoints in clinical trials.

Dapagliflozin (an active ingredient of Forxiga) was registered in monotherapy for the treatment of type 2 diabetes, and also in combination with Metformin as a starting drug and with a progressive course of the disease.

Today, the accumulated experience makes it possible to use the medication for diabetics in all possible combinations:

  • with sulfonylurea derivatives (including complex therapy with metformin);
  • with gliptins;
  • with thiazolidinediones;
  • with DPP-4 inhibitors (possibly combined with metformin and analogs);
  • with insulin (plus oral hypoglycemic agents).

Recommendations for use

The oral tablets are used at any time of day, regardless of food. Tablets with 5 mg and 10 mg dosages are packed in the amount of 28, 30, 56 and 90 pieces. The standard recommended dosage is 10 mg/day. One or two tablets, depending on the dosage, should be taken once along with water.

If liver function is impaired, the doctor reduces the norm by one and a half to two times (with initial therapy 5 mg/day).

To prevent hypoglycemia, you should carefully us Forxiga with an insulin therapy and in combination with medications of the sulfonylurea group.

For maximum effectiveness, it is advisable to take the medicine at the same time of day.

Advantages of Forxiga

  • Efficiency does not depend on the sensitivity of tissues to insulin;
  • The mechanism of action does not load β-cells;
  • Mediated enhancement of β-cell potency;
  • Decreased insulin resistance;
  • Minimal risk of hypoglycemia, compared to placebo.
  • The hypoglycemic effect of the medication is guaranteed for any condition of the pancreas and β-cells.

But in spite of the fact that the mechanism of action of the drug is insulin-dependent, one can expect an indirect improvement in the functions of β-cells and due to the primary mechanisms of action of improving the sensitivity of tissues to insulin.

The duration of the disease does not affect the ability of dapagliflozin. Unlike other analogs, effective only the first 10 years of development of diabetes, Forxiga can be successfully used in case of “experienced” diabetes.

After the end of the course of taking the inhibitor, the therapeutic effect persists long enough. It depends on the efficiency of the kidneys.

The drug helps hypertensives monitor blood pressure, providing an easy hypotensive effect. This, in turn, helps reduce the risk of developing cardiovascular conditions.

Forxiga quickly normalizes the indicators of muscle glycemia, but the concentration of cholesterol (both total and LDL) may increase.

Potential Forxiga side effects may include:

Effect
Percentage

10%

Forxiga used to treat the following diseases:

Disease
Percentage

  1. Danielle G. Schmidt says:
    4.0 rating

    Forxiga for Diabetes mellitus type ii

    I take for about 2 months Forxiga. Oh, woe. First, I got a fierce fungal infection. After consultation with the doctor, who declared that she would continue to take them anyway, and at the same time ointment and suppositories, it improved. But now I already have the second urinary tract infection. So bad and painful. I only peed blood. I dropped it off immediately. Too bad. I thought it would help me.

  2. Mike C. Leonard says:
    4.0 rating

    Forxiga for Diabetes mellitus type ii

    I have got a fungal infection resulting in a urinary tract infection. I was close to kidney failure and peed constantly in my pants. It was not possible for me to work every day. I almost died of side effects. Today I am almost unable to work after 2 years

    Side effects: Itching
  3. Sandra S. Lochner says:
    4.5 rating

    Forxiga for Diabetes mellitus type ii

    A very good medicine, I can only recommend it. Sometimes itching in the genital area, but otherwise no side effects. My long-term value improved from 9.9% to 7.1%, neither metformin nor sitagliptin did it before, I’m thrilled. Something else I have to say, I eat like a non-diabetic. If I held back a little, my values would be optimal.

    Side effects: Itching
  4. Sharon S. Carrasco says:
    4.0 rating

    Forxiga for Diabetes mellitus type ii

    I took from 19.10.2015 Forxiga 10 mg. At first, I did not notice any side effects when the first pack was empty for Doc ordered. He prescribed me this medicine again after blood glucose measurement. First noticed nothing. The side effects in the description, I have not read, because I say that I would always have these side effects! On 20.12.2015, after I had back pain in the genital area strong itching itching strong, could not sleep, I read the leaflet with the side effects. I realized a lot about me. Side effects I had ALL! Vaginal discharge, itching, back pain, itching all over. These are just the worst side effects, right now !!! I stopped the drug and lo and behold. No more back pain, itching in the vaginal area goes back considerably. The Propezeit of the drug was too short – unfortunately.

    Side effects: Itching
  5. Stacy M. McAteer says:
    3.5 rating

    The side effect of weight reduction and thereby mainly degradation of the abdominal fat occurred relati’v quickly. Unfortunately, the blood sugar levels have not reacted yet, are still too high (about 8, early even about 9) As an adverse reaction occurred after about 4-3 months on an unpleasant, painful fungal infection, which, however, with ointment relatively quickly passed

    Side effects: Fungal infection
  6. Jessica M. Basel says:
    4.0 rating

    Forxiga for Diabetes mellitus type ii

    Through the drug, I achieved a weight reduction of 14 kg, the blood pressure dropped and especially good was the morning increased sugar level and overall also the quarter-year value. After taking it for three or four weeks, I had to deal with a severe skin and fungal infection that was treated without discontinuing Forxiga and has not occurred since. For me the best of my 3 diabetes medications! The increased urination belongs to the mode of action of the drug and therefore does not count as a side effect for me.

    Side effects: Fungal infection
  7. Miguel E. Berry says:
    3.5 rating

    Forxiga for Diabetes mellitus type ii

    After eight weeks only insignificant weight reduction (= 1 kg), blood sugar levels remain high, urinary urgency extremely unpleasant (for example, in the city). Discontinued with onset of slight incontinence Forxiga.

    Side effects: Urinary frequency
  8. William M. Brown says:
    4.0 rating

    Forxiga for Diabetes mellitus type ii

    Lowers the blood sugar fast and constantly. Blood pressure readings were also lowered. That was a pleasing side effect. Adverse reactions: severe urinary frequency (even at night). In addition, very quickly einzende yeast infection, which was also painful. Itching on the penis and burning while urinating were unbearable. After discontinuing the drug, the side effects disappeared. After four weeks break, I made another attempt, but I had to stop quickly. The same side effects reappeared immediately.

  9. Alan M. Gross says:
    4.5 rating

    Forxiga for Diabetes mellitus type ii

    No side effects very good tolerability have decreased in the period of 3 months 14 kg and my blood sugar levels are back in the normal range for diabetics max.140 mg / dl

    Side effects: No side effects