Fluvastatin contraindications and warnings


Following is information on contraindications to the use of fluvastatin in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should Fluvastatin not be used?

Fluvastatin should not be used with:

  • Hypersensitivity to the active substance
  • Liver disease, a permanent increase in blood liver counts or a bile flow disorder
  • Skeletal muscle disease with muscle fiber destruction or an increase in blood levels suggestive of it.

Fluvastatin should only be used with caution and only after a careful risk-benefit assessment at

  • People over 70 years old
  • Alcohol Abuse
  • favorable factors for a muscle disorder such as
    • renal dysfunction
    • thyroid
    • hereditary muscle disorders in personal history or family
    • muscle damaging effects from an earlier ingestion of a fibrate or statin
    • Situations in which increased blood levels of the drug may occur, for example, in Asian patients, liver or kidney dysfunction or concomitant use of other agents such as ciclosporin (for organ rejection) and some AIDS agents from the HIV-1 protease inhibitor group
    • simultaneous use of fibrates.

What should you watch out for during pregnancy and lactation?

Fluvastatin should not be taken during pregnancy and lactation because the active substance may cause harm to the baby.

What should be considered in children?

Manufacturers provide different information on the use of the active substance in children. Some do not allow the use, others from nine years. Then, however, only cases may be treated in which the lipid metabolism disorder was acquired hereditary and is only pronounced on one gene (heterozygous familial hypercholesterolemia). Adolescent patients will be placed on a standard cholesterol-lowering diet before starting treatment, which should be continued throughout the treatment period.

If you are under 18 years of age, you should read this leaflet carefully or consult a doctor or pharmacist.

Warnings and Precautions

  • Pain, weakness and special sensitivity of the musculature must be reported to the doctor immediately.
  • Before and after therapy, blood levels of liver should be checked.
  • An ophthalmological examination should be carried out before and after the therapy, as the active substance may cause a clouding of the lens.
  • In case of muscle problems and more than five times increase in certain muscle values, treatment must be discontinued.
  • In case of difficulty breathing, coughing, exhaustion, weight loss and fever the treatment should be stopped.
  • If a patient already has risk factors for the development of diabetes, the blood sugar must be checked regularly during treatment.
  • If there is persistent muscle weakness despite the end of treatment, this must be reported immediately to the doctor.

Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.