What side effects can Fluvastatin have?
Below you will find the most important information about possible known side effects of Fluvastatin.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Common side effects: constipation, diarrhea, flatulence, stomach upset, abdominal pain, nausea, heartburn, dizziness, headache, insomnia, joint pain, fatigue.
Occasional side effects:
elevation of liver function, altered muscle metabolism.
Rare side effects:
skin rash, hives, muscle tenderness, muscle aches, muscle weakness, muscle disorders.
Very rare side effects:
pancreatitis, sensory disorders, decreased sensitivity to touch, disturbed sensation of touch, nerve disorders, skin lesions such as rash, inflammation or blistering; Vascular inflammation, muscle inflammation, hepatitis, decrease in platelets, muscle cell death (rhabdomyolysis), water retention in the tissue, changes in muscle levels in the blood, muscle breakdown due to an autoimmune reaction.
All representatives of the drug group of statins seems to have a harmful effect on the nerves, which is particularly evident in the legs. Numbness, burning sensations or muscle twitching are the signs. For such symptoms, treatment with a statin should be stopped immediately. Diabetics are particularly at risk because the doctor frequently associates the described symptoms with nerve damage due to diabetes (diabetic neuropathy) and the causative statin is not discontinued.
During or after treatment, muscle atrophy may very seldom occur due to an autoimmune reaction. Signs of persistent muscle weakness persist despite the end of treatment. Such a muscle weakness must be communicated to the doctor immediately.
Other side effects common to all statins, such as sleep disorders, memory loss, sexual disorders, depression and damage to the air sacs (interstitial lung disease) may also occur with fluvastatin.
Like all statins, fluvastatin may increase blood sugar levels and promote the development of blood sugar (diabetes mellitus). Frequency is dependent on the presence or absence of other risk factors, such as pre-existing excess blood sugar, obesity, high blood pressure, and the extent of the lipid metabolism disorder.
What interactions does fluvastatin show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
The combination of the drug phenytoin for epilepsy with fluvastatin may increase the concentration of phenytoin in the blood and cause side effects. The phenytoin concentration must therefore be checked. Anticoagulants may also be potentiated in combination with fluvastatin in their effects and side effects. Therefore, the doctor must adjust the dose of anticoagulants. Otherwise, dangerous bleeding may occur.
Dose adjustment may be needed in patients taking rifampicin for tuberculosis, as rifampicin may decrease the fluvastatin concentration and thus the effect of the statin. In addition, anion exchange resins such as colestyramine must be used at least four hours before taking fluvastatin, as the anion exchange resins will otherwise bind the active substance and reduce its effect.
Special medical attention is warranted when co-administered with fluvastatin and fibrates, the active substance nicotinic acid, the antifungal agent itraconazole and the macrolide antibiotic erythromycin. These combinations increase the risk of dangerous muscle diseases.
Co-administration of statins with cyclosporine can lead to severe cases of rhabdomyolysis muscle disease. If the simultaneous administration of the active ingredients is unavoidable, the statins must be dosed weaker by the doctor.