Fluoxetine side effects

What side effects can Fluoxetine have?

Below you will find the most important information about possible known side effects of Fluoxetine.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).

Very common side effects:
nausea.

Common side effects:
indigestion, diarrhea, constipation, weight gain, abdominal pain, palpitations, weakness, drowsiness, sedentary lifestyle, anxiety, nervousness, tremor, headache, dry mouth, insomnia, drowsiness, vomiting, anorexia, dizziness, sweating, excitement , Thought disorder, malaise.

Uncommon side effects:
joint pain, muscle pain, disturbed motion control, sudden fall in blood pressure, confusion, involuntary muscle contractions, delayed ejaculation, rash, itching.

Rare side effects:
liver function disorders, movement disorders with increase or decrease of the movements or the state of tension of the muscles, tachycardia, blistering skin rashes, photophobia, convulsions, strong inner restlessness and drunkenness with loss of inhibition (mania), delusions, lowering of sodium blood level, morbid flow of milk, skin haemorrhages.

Specialties:
Especially at the beginning of treatment it can lead to tormenting restlessness and restlessness of limbs (akathisia).

Diabetics may develop hypoglycaemia after taking the drug. This can lead to diabetics having to be readjusted by their doctor.

Headache, nausea, drowsiness, sensory disturbances and anxiety may occur after discontinuation of the drug. These complaints usually resolve within two weeks, but may last for two to three months or more. Cessation of treatment should therefore be limited to weeks or months.

Recent studies have shown that Fluoxetine’s work on bone augmentation and degradation cells is particularly detrimental to long-term use. This can lead to increased fractures, or the development of osteoporosis.

What interactions does fluoxetine show?

Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).

Concomitant use of MAOI antidepressant medications may result in serious, sometimes fatal, reactions. After stopping treatment with MAO inhibitors, wait two weeks before starting to use fluoxetine. After stopping fluoxetine treatment, MAO inhibitors should be used for at least five weeks.

Concomitant use of tryptophan may cause agitation, restlessness and gastrointestinal disturbances.

The excretion of diazepam can be delayed and thus its effect prolonged.

The blood levels of lithium, neuroleptics and tricyclic antidepressants and thus their effects may be increased.

Changes in phenytoin blood levels (against epilepsy) have been reported with concomitant fluoxetine use.

If alcohol is consumed at the same time, the alcohol effect can be increased.

If you take medications that affect blood clotting (anticoagulants), co-administration of fluoxetine may increase your tendency to bleed.

If herbal preparations containing St. John’s wort are taken, too much side effects are possible.

Co-administration of medicinal products such as tramadol or triptans (for migraine) may increase the risk of serotonin syndrome with hot flashes and changes in the heart muscle. With the simultaneous use of triptans, there is the additional risk of constriction of the coronary arteries and hypertension.

If breast cancer patients are treated with the cytostatic tamoxifen, fluoxetine may limit its effectiveness. The active substance inhibits the enzyme for the conversion of tamoxifen into its active form endoxifen. As a result of this interaction, the mortality rate in the affected patient group increases. In order not to jeopardize the success of tamoxifen treatment, the doctor should choose venlafaxine as an antidepressant because it does not interfere with the enzyme.

Potential Fluoxetine side effects may include:

Effect
Percentage

25%

16%

12%

11%

10%

9%