What side effects can Fentanyl have?
The following is the key to possible known side effects of fentanyl.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Very common side effects:
drowsiness, sweating, itching, rash, distress, dizziness, headache, mood changes, addiction, dry mouth, nausea and vomiting, constipation, bladder dysfunction, slow heartbeat.
Common side effects:
Confusion, depression, anxiety disorders, hallucinations, nervousness, indigestion, loss of appetite.
Uncommon side effects:
Insomnia, excitement, tremors, sensory disturbances, speech disorders, memory loss, hypertension, low blood pressure, rapid heartbeat, respiratory disorders, redness, diarrhea.
Rare side effects:
blurred vision, cardiac arrhythmia, dilation of blood vessels, hiccups, fluid retention in tissues (edema), feeling cold.
Very rare side effects:
seizures, coordination disorders, psychosis, agitation, breathlessness, urinary bladder pain, frequent urination, allergic shock, allergic skin reactions, weakness, sexual dysfunction, confusion, painful bloating, intestinal obstruction.
Patients who are switched from other opioids to fentanyl-containing patches often complain of symptoms of withdrawal. These may be in need of treatment.
What interactions does fentanyl show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Fentanyl should not be combined with other opioid analgesics as it can cause severe circulatory and respiratory problems.
It also prohibits co-administration with antidepressants from the subgroups of MAO inhibitors, the selective serotonin reuptake inhibitors or selective serotonin norepinephrine reuptake inhibitors, as this leads to a life-threatening serotonin syndrome with impaired consciousness, fever, high blood pressure and movement disorders.
Central nervous system depressants such as barbiturates and benzodiazepines may also cause respiratory depression when given concomitantly and should not be taken with fentanyl. The same applies to the consumption of alcohol.
Sedatives, analgesics, and general anesthetics (eliminate the sensation of pain) and muscle relaxants (muscle relaxants) enhance the tiring and soothing effects of fentanyl.
Concomitant use of other opioid analgesics, such as morphine, oxycodone, hydromorphone or pethidine, reduces the effects of fentanyl, while increasing the risk of dangerous side effects.
Painkillers such as pentazocine or buprenorphine or the antibiotic rifampicin also reduce the analgesic effects of fentanyl and can trigger the typical withdrawal symptoms in opioid addicts.
Cimetidine and diltiazem, as well as other drugs that affect liver metabolism, such as erythromycin, ketoconazole, itraconazole or ritonavir, inhibit fentanyl degradation in the body, enhancing its effects. They should therefore not be taken together with fentanyl.
If the muscle relaxants pancuronium or vecuronium and fentanyl are used at the same time, the effects of these agents may be increased.