What side effects can letrozole have?
Below you will find the most important information about possible known side effects of letrozole.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Very common side effects:
sweats, joint pain, hot flushes, fatigue, feeling weak.
Common side effects:
loss of appetite, increased appetite, excess blood cholesterol, depression, headache, dizziness, nausea and vomiting, heartburn, constipation, diarrhea, hair loss, rash, muscle aches, bone pain, bone loss (osteoporosis), broken bones , Malaise, water retention in the arms and legs, weight gain.
Uncommon side effects:
urinary tract infections, tumor pain (except in extended supportive therapy), white blood cell deficiency, water retention in tissues, anxiety disorders including nervousness , Irritability, drowsiness, sleep disorders, memory disorders, sensory disturbances, numbness, taste disorders, cataracts, eye irritation, blurred vision, palpitations, rapid heartbeat, acute thrombosis, increase in blood pressure, respiratory distress, abdominal pain, oral dryness, dry mouth, liver enzyme increase, itching, dry Skin, hives, arthritis, frequent urination, vaginal bleeding, vaginal discharge, dry vagina, chest pain, fever, dry mucous membranes, thirst, weight loss.
Rare side effects:
brain stroke, occlusion of the pulmonary arteries, general arterial occlusions, stroke.
What interactions does letrozole show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
No studies have been done on the use of letrozole in combination with other anticancer agents.
For other agents no significant interaction with letrozole is known.
Among other things, letrozole inhibits the enzyme cytochrome P-450 2A6 in the liver. Active substances which are broken down by this enzyme and which are toxic even with a slight overdose, should preferably not be taken concomitantly with letrozole.