Erythromycin contraindications and warnings


Following is information on contraindications to the use of erythromycin in general, pregnancy, breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should erythromycin not be used?

In the case of hypersensitivity to erythromycin or other macrolide antibiotics, the active substance should not be used. In addition, erythromycin should not be used with certain antiarrhythmic drugs, cisapride, pimozide, terfenadine and astemizole, as it increases the risk of life-threatening cardiac arrhythmias. The same applies to patients who, for other reasons, have an increased risk of cardiac arrhythmias in the sense of QT prolongation. These also include patients with a slow heart rate, severe heart failure and potassium or magnesium deficiency.

In severe hepatic impairment, erythromycin should only be prescribed by the physician after careful consideration of the benefits and risks.

What should you watch out for during pregnancy and lactation?

During pregnancy and lactation, the doctor must carefully weigh the benefit and risk of treatment because it is not known if erythromycin can harm the baby.

What should be considered in children?

Erythromycin can also be used in children. However, the drug should be given to toddlers and infants only after careful consideration of benefits and risks by a doctor, because erythromycin may harm the children’s liver.

Warnings and Precautions

  • If there are signs of an allergic reaction while taking the medicine, seek medical advice immediately.
  • If the medication is used for several weeks, the doctor must regularly check the blood, liver and kidneys.
  • In case of persistent diarrhea, a doctor must be consulted.
  • When combined with calcium channel blockers, the doctor should prescribe azithromycin instead of the drug.

Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.