What side effects can Erythromycin have?
Below you will find the most important information about possible known side effects of erythromycin.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Uncommon side effects:
nausea, nausea, vomiting, flatulence, abdominal pain, loose stools, diarrhea, increase in liver enzymes, allergic reactions with redness and rash.
Rare side effects:
Water retention in tissues (Quincke edema), joint swelling, drug fever, jaundice, gall congestion with nausea, vomiting, itching, fever, abdominal cramps, blood cell lesions.
Very rare side effects:
anaphylaxis, life-threatening skin reactions such as erythema exsudativum multiforme and Stevens-Johnson syndrome; Gastric obstruction, hepatitis, liver enlargement, liver failure, ear noises, deafness, cardiac arrhythmias, pancreatitis, nephritis.
When taking erythromycin may cause the onset of previously unnoticed muscle weakness (myasthenia gravis).
During erythromycin therapy, fungal colonization may be associated with inflammation of the oropharynx, gastrointestinal tract or genitalia. In addition, bacteria that have resistance to erythromycin or that naturally do not respond to the drug can multiply, leading to serious infections. Severe diarrhea may be the cause of a potentially life-threatening bacterial colonic inflammation. This should therefore be excluded by the doctor.
What interactions does erythromycin show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Erythromycin should not be combined with tetracyclines or the active substances chloramphenicol, clindamycin, lincomycin, streptomycin or colistin as the effects of the active substances may cancel each other out
Taking erectile dysfunction medications such as sildenafil, tadalafil and vardenafil may increase their levels in the blood, increasing the risk of dangerous side effects. The same applies to theophylline, carbamazepine, clozapine, phenytoin and valproic acid. Erythromycin also increases the effects and side effects of alfentanil, bromocriptine, quinidine, disopyramide, pentamidine, felodipine, methylprednisolone, midazolam, triazolam, tacrolimus, digoxin and zopiclone as well as the drug groups of anticoagulants and ergot alkaloids. Erythromycin can still not be used with certain antiarrhythmic drugs and the drugs cisapride, pimozide, terfenadine or astemizole, because otherwise the risk of life-threatening cardiac arrhythmia increases.
Protease inhibitors and the active ingredient cimetidine inhibit the breakdown of erythromycin and thus increase the risk of serious side effects. Omeprazole and erythromycin increase their concentration in the blood and thus increase their effects and side effects.
Lovastatin, together with erythromycin, may cause muscle breakdown (rhabdomyolysis). In addition, the kidney damaging effect of cyclosporin A is enhanced by erythromycin.
The effect of estrogen-progestogen combined contraceptives (the pill) can be affected by erythromycin. Therefore, other contraceptive measures should be taken during the treatment.
erythromycin may increase the effect of calcium channel blockers (for high blood pressure) especially in the elderly so that it comes to life-threatening drop in blood pressure. In combination, the doctor should therefore resort to azithromycin.