Budesonide has anti-inflammatory and therefore decongestant on the mucous membranes of the bronchi. Therefore, it is used as an inhalant aerosol, especially for long-term therapy in bronchial asthma, chronic bronchitis and chronic obstructive pulmonary diseases such as COPD.
What is the purpose of this ingredient?
- Treat complaints of respiratory diseases
- Alleviate symptoms of inflammatory bowel disease such as Crohn’s disease and ulcerative colitis
- Reduce symptoms of chronic bronchitis, bronchial asthma and COPD
- Relieve symptoms of runny nose and sinusitis
- treat allergy and hay fever
This is how Budesonid works
Below you will learn more about the fields of application and the mode of action of budesonide.
Please also read the information on the drug groups glucocorticoids, anti-inflammatory drugs, antiasthmatics, to which the active ingredient budesonide belongs.
Applications of the active substance budesonide
Budesonide has anti-inflammatory and therefore decongestant on the mucous membranes of the bronchi. Therefore, it is used as an inhalant aerosol especially for long-term therapy in bronchial asthma, chronic bronchitis and chronic obstructive pulmonary diseases such as COPD.
As a nasal spray, the active ingredient causes the nasal mucosa to decongest and reduces secretion in cases of runny nose and sinusitis or hay fever, if they are caused by an allergy. In addition, nasal breathing in existing polyps can be significantly improved by budesonide.
Because of its anti-inflammatory effect, budesonide can also be used as a tablet, suppository or so-called rectal foam for the treatment of inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis.
For the following application areas of Budesonid , in-depth information is available:
- chronic bronchitis
- chronic inflammatory bowel disease
Action of budesonide
The active substance budesonide is a potent glucocorticoid. Budesonide is absorbed and metabolized very quickly at the place of application. Therefore, almost exclusively local effects and side effects occur. In particular on the lungs and on the bronchial system and on the mucous membrane of the gastrointestinal tract, it develops all the typical properties of this group of drugs such as inhibition of inflammation, reduction of mucus production and water retention and reduction of allergic reactions.
The active substance budesonide is taken up in the cell and bound to a receptor. Thus, the formation (biosynthesis) of certain proteins is initiated, which reduce the formation of inflammatory substances. The full therapeutic effect therefore occurs with a delay. Budesonide is therefore not suitable for the treatment of acute respiratory distress in an asthma attack. However, due to its long-lasting anti-inflammatory effect, it is widely used to treat respiratory diseases such as bronchial asthma, chronic bronchitis and COPD. Because the active ingredient causes the mucous membranes in the bronchial area to decongest and the narrowed airways are widened. In addition, the formation of bronchial mucus is reduced and its toughness reduced and the bronchial muscles are relaxed.
Due to its decongestant effect, budesonide can also be used in the form of nasal sprays for the nasal congestion associated with allergic rhinitis. Again, the active ingredient reduces the secretion and thus improves nasal breathing.
Its strong anti-inflammatory action also distinguishes the drug for the treatment of inflammatory bowel disease such as Crohn’s disease and ulcerative colitis. Budesonide inhibits inflammatory processes in the intestinal mucosa in the form of a rectal foam. The exact mechanism of action is not yet fully understood. It only seems certain that budesonide is purely local in this application form. Corresponding tablets have an enteric coating that protects them from the digestive juices after ingestion into the colon. After dissolving this coating, the digestive juices form a tough gel with the coating. As a result, budesonide is slowly distributed throughout the colon, where it can have a specific local effect.