What side effects can Etanercept have?
Below is a list of the most important possible side effects of etanercept.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Very common side effects:
infections (including upper respiratory infections, bronchitis, cystitis, skin infections), injection site reactions (including bleeding, bruising, redness, itching, pain, swelling).
Common side effects:
Allergic reactions, autoantibody formation, itching, fever.
Uncommon Side Effects:
Serious infections (including pneumonia, dermatitis, bacterial arthritis, septicemia), platelet deficiency, lung disease (including connective tissue lung alteration, pneumonia), vascular swelling, hives, skin rash.
Rare side effects:
Tuberculosis, anemia, white blood cell deficiency, neutrophil deficiency, deficiency of all blood cells, severe allergic reactions (including vascular swelling, bronchospasm), seizures, multiple sclerosis-like, optic nerve inflammation, cross-sectional inflammation ), Blood liver value increase, skin blood vessel inflammation, skin diseases such as lupus erythematosus, cancers.
Very rare side effects:
special forms of anemia (aplastic anemia).
Side effects without frequency:
Myocardial insufficiency worsening.
Patients receiving a new infection during etanercept treatment should be frequently screened by the physician. The use of the drug should be discontinued if the infection is severe. Above all, patients should seek medical advice if signs of tuberculosis occur during or after etanercept therapy. Such are, for example, persistent cough, loss of strength, weight loss and a slight increase in body temperature.
There is some evidence that etanercept may cause white matter disease and brain swelling. Signs of this include photophobia, short-term swindle, headache, horizontal double vision and nausea and vomiting. If it comes to such complaints, consult a doctor immediately.
What interactions does etanercept show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Increased numbers of serious infections have been reported in adult patients treated concomitantly with the immunologic Anakinra and etanercept compared to patients treated with either Enbrel or Anakinra only. In combination with the immunologic methothrexate, there was also a lack of neutrophilic blood cells. When etanercept was combined with the immunological drug abatacept, there was an increased occurrence of serious side effects. Therefore Etanercept must not be given together with Anakinra or Abatacept.
There was a marked reduction in white blood cell counts when combined with etanercept and sulfasalazine (for inflammatory bowel disease). Whether this reduction is physically detrimental is not known.
Live vaccines should not be co-administered with etanercept. So far, apparently no etanercept treated patients were infected with live vaccines with diseases. Nevertheless, it is recommended that all necessary vaccinations are completed in juvenile patients with joint inflammation, as far as possible before beginning treatment.