About Enbrel

4.0 rating based on 28 ratings
Rating: 3.8 Reviews: 28
About Enbrel

The active substance is used in specific diseases in which inflammatory reactions play a role. For example, in inflammatory rheumatic diseases such as rheumatoid arthritis of adults and adolescents, progressive spinal curvature (Bekhterev’s disease) and psoriasis, when it affects the joints or causes severe skin complaints.

What is the purpose of this ingredient?

  • suppress inflammatory reactions

This is how Etanercept works

Below you will learn more about the fields of application and the mode of action of Etanercept.
Please also read the information on the drug groups immune boosting and -defensive agents, anti-inflammatories, to which the active ingredient etanercept belongs.

Applications of the active substance etanercept

The active substance is used in specific diseases in which inflammatory reactions play a role. So with inflammatory rheumatic diseases such as rheumatic arthritis (RA) in adults and adolescents, the progressive curvature of the spine (ankylosing spondylitis) and psoriasis (psoriasis) when it attacks the joints and causes severe skin complaints.

In moderate to severe joint rheumatism of adults etanercept (another anti-inflammatory drug), can be used in combination with methotrexate are used when other means have (including methotrexate) is insufficiently worked. The same applies to the corresponding forms of articular rheumatism in adolescents. In case of intolerance to methotrexate or if continuation of treatment with methotrexate is not possible, etanercept may also be used alone. Also for individual therapy, the drug is suitable for adult Bechterew’s disease. In severe and progressive forms of articular rheumatism, the doctor may also prescribe etanercept. If rheumatoid arthritis in adults is caused by psoriasis, etanercept will be used if previous special therapy was inadequate.

In single therapy or in combination with methotrexate, etanercept prevents the progression of X-ray detectable joint damage and improves physical function.

Another use of etanercept is the skin complaints of adult patients with moderate to severe psoriasis. The condition is that the symptoms could be improved by other immunologicals including cyclosporine, methotrexate or psoralen / light therapy (PUVA), these treatments have not been tolerated or did not apply in the first place.

For the following application areas of Etanercept , in-depth information is available:

  • inflammatory rheumatic diseases
  • Psoriasis

Effect of Etanercept

Much of the joint pain in inflammatory rheumatic diseases such as rheumatoid arthritis and ankylosing spondylitis and skin and joint disease psoriasis is caused by the body’s own inflammatory substances. These substances are regulated by a system in which a protein, the so-called tumor necrosis factor (TNF) plays a crucial role. The mechanism of action of etanercept is believed to inhibit the binding of TNF to the specific cell surface TNF receptors. Thus TNF can not unfold its effect; the TNF-induced inflammatory reactions of the cells are avoided.

Etanercept consists of 934 amino acids (protein building blocks) and would be destroyed in the digestive tract. Therefore, an application of the drug is possible only in the form of syringes.

Potential Enbrel side effects may include:

Enbrel used to treat the following diseases:

  1. Mary S. Cross says:
    4.5 rating

    Enbrel for Arthritis

    The preparation helped me but had bigger expectations. The liver values became progressively worse. Foot and leg cramps, especially at night, increased. Otherwise, I have not been so good at detecting side effects. Breast, however, has become much larger. Infections, smells and tastes decreased significantly. However, what I found to be particularly negative was the nettle fever that I unquestionably attributed to Enbrel. At the moment I’m pausing for about 8 weeks with the 1x weekly spraying. However, the general condition of the movements has become much worse. So inject Enbrel again, so that the pain is reasonably bearable. Every tablet has some side effects. However, the quality of life increases significantly, if you can walk properly and not so much pain.

    Side effects: Muscle cramps
  2. Chris J. Harrison says:
    4.5 rating

    Enbrel for Arthritis

    I did not tolerate Mtx as Lantarel at all, after every injection 3 days diarrhea. For a year, I inject Metex without any side effect. Before Enbrel, I injected Humira for a year and was painless. Humira had to be discontinued because it was probably the cause of polyneuropathy. Now I have been injecting Enbrel for a year and my rheumatism is almost gone. After 6 months, I had a sudden hearing loss that did not go away. A slight gear uncertainty now and then, and strong muscle spasms are now my problem. I hope that the combination is not the cause of this medication.

  3. William J. Wood says:
    3.5 rating

    Enbrel 25 ml I take for 2.5 years once a week and am thrilled. Before trying some medications, nothing helped, except the daily use of the painkiller Voltaren (capsules), which I did not need to take again after the first Enbrelinjektion until today. However, I have increased in this time by about 7 kg and from time to time with skin fungus to do. Otherwise, I have noticed no other side effects. Great drug!

    Side effects: Increase in weight
  4. Larry E. Moses says:
    4.0 rating

    Enbrel for Ankylosing spondylitis

    With Enbrel came after a short time relief. For years, I have geqäult and no one has really found something. After a rheumatologist discovered Bekhterev’s disease, we immediately started therapy. I really can not say bad. The injection was getting used to at the beginning. But otherwise it was only uphill. After half a year I did not feel any pain anymore. Only small, disadvantage, despite the many movement I owe Enbrel, I have 8 kg increased.

    Side effects: Increase in weight
  5. Linda S. Jarnagin says:
    3.5 rating

    Enbrel for Rheumatism

    Enbrel personally has not brought me much. The inflammations in the joints still occur. I give Enbrel once a week. by pin. The supply is painful. Prednisolone has given me tons of pounds over the years. But it had continued, because the pain was bearable. Only when lower doses did not bring much did I sell the long-term therapy. After about 1 year, I had lost 12 pounds. Today I take Prednisolone only in acute episodes. I have no side effects here.

    Side effects: Increase in weight
  6. Debra T. Garcia says:
    4.5 rating

    Enbrel for Chronic polyarthritis

    Enbrel I administered at the beginning every 3 days and have learned to live with Enbrel .. Meanwhile, I inject myself every 7 – 8 days …. Thanks Enbrel I am active again (sports, cycling …) take part in life again. Side effect is only if I do not inject longer z.b because of cold I get a small rash at the injection. But rather a few pimples than can not run, lift, grasp. A drug that finally HELPS

    Side effects: No side effects
  7. Faye G. Valencia says:
    4.0 rating

    Have had Bechterew’s disease for 3 years. At the beginning I got all drugs in turn. None of them helped. Still had unbearable pain in the back. Then my Othopäde started the Enbreltherapie. It’s brilliant. I am completely painless. I’ll never get rid of the morning stiffness, but it’s still worth it anyway. Above all, I have a weekly dose of 25 mg. I am totally satisfied with Enbrel.

    Side effects: No side effects
  8. Debra J. Montgomery says:
    5.0 rating

    Enbrel for Psoriatic arthritis

    Suffer from psoriatic arthritis for about 25 years. Psoriasis is only mild to moderate. Mostly the scalp is affected. Most of my problems were arthritis, which in some cases affected almost all joints. After an odyssey from doctor to doctor, after various hospital stays, countless therapies and surgery finally the breakthrough. About 6 years ago I got the first time Enbrel prescribed. The success came pretty fast. Already after about 4 weeks a substantial improvement had occurred. A pending hand OP could be avoided thanks to Enbrel. I was a completely different person. A completely new quality of life. Meanwhile, I was able to reduce the dose of twice a week to every two weeks. And I’m still doing really well. Do not need additional medication. In addition, the side effects are very limited for me. Very rarely a cold. mfg tiniH

    Side effects: No side effects