About Enbrel

4.0 rating based on 28 ratings
Rating: 3.8 Reviews: 28
About Enbrel

The active substance is used in specific diseases in which inflammatory reactions play a role. For example, in inflammatory rheumatic diseases such as rheumatoid arthritis of adults and adolescents, progressive spinal curvature (Bekhterev’s disease) and psoriasis, when it affects the joints or causes severe skin complaints.

What is the purpose of this ingredient?

  • suppress inflammatory reactions

This is how Etanercept works

Below you will learn more about the fields of application and the mode of action of Etanercept.
Please also read the information on the drug groups immune boosting and -defensive agents, anti-inflammatories, to which the active ingredient etanercept belongs.

Applications of the active substance etanercept

The active substance is used in specific diseases in which inflammatory reactions play a role. So with inflammatory rheumatic diseases such as rheumatic arthritis (RA) in adults and adolescents, the progressive curvature of the spine (ankylosing spondylitis) and psoriasis (psoriasis) when it attacks the joints and causes severe skin complaints.

In moderate to severe joint rheumatism of adults etanercept (another anti-inflammatory drug), can be used in combination with methotrexate are used when other means have (including methotrexate) is insufficiently worked. The same applies to the corresponding forms of articular rheumatism in adolescents. In case of intolerance to methotrexate or if continuation of treatment with methotrexate is not possible, etanercept may also be used alone. Also for individual therapy, the drug is suitable for adult Bechterew’s disease. In severe and progressive forms of articular rheumatism, the doctor may also prescribe etanercept. If rheumatoid arthritis in adults is caused by psoriasis, etanercept will be used if previous special therapy was inadequate.

In single therapy or in combination with methotrexate, etanercept prevents the progression of X-ray detectable joint damage and improves physical function.

Another use of etanercept is the skin complaints of adult patients with moderate to severe psoriasis. The condition is that the symptoms could be improved by other immunologicals including cyclosporine, methotrexate or psoralen / light therapy (PUVA), these treatments have not been tolerated or did not apply in the first place.

For the following application areas of Etanercept , in-depth information is available:

  • inflammatory rheumatic diseases
  • Psoriasis

Effect of Etanercept

Much of the joint pain in inflammatory rheumatic diseases such as rheumatoid arthritis and ankylosing spondylitis and skin and joint disease psoriasis is caused by the body’s own inflammatory substances. These substances are regulated by a system in which a protein, the so-called tumor necrosis factor (TNF) plays a crucial role. The mechanism of action of etanercept is believed to inhibit the binding of TNF to the specific cell surface TNF receptors. Thus TNF can not unfold its effect; the TNF-induced inflammatory reactions of the cells are avoided.

Etanercept consists of 934 amino acids (protein building blocks) and would be destroyed in the digestive tract. Therefore, an application of the drug is possible only in the form of syringes.

Potential Enbrel side effects may include:

Enbrel used to treat the following diseases:

  1. Barry M. Masters says:
    4.0 rating

    Enbrel for Ankylosing spondylitis

    Initial condition ankylosing spondylitis (ill for 20 years): Significant changes in the vertebral body visible on the radiograph, constant morning stiffness (about 30 min), slightly restricted mobility of the spine, jogging due to back pain not possible, long sitting very uncomfortable (therefore no theater visits etc. ) In short: clear restriction of the quality of life. After one year of Enbrel (once a week 50mg), all symptoms are pushed back so far that one could speak of ‘healing’. However, the first pain occurs after about two weeks without injection. Side effect Enbrel: From time to time allergic reactions occurred at the injection site. Slight swelling and redness similar to a wasp sting. The switch to Humira (40mg every two weeks) was easy. Humira seems to work a little better subjectively. Injection is a little more painful, but it has not come to the allergic reactions. Initial condition Chron’s disease (ill for 23 years): change between constipation and daily multiple spasmodic bowel movements of increasingly slimy consistency and extreme subsequent laxity. Two strictures a fistula (all operated on), flatulence, no pain. In short: clear restriction of the quality of life. Ability to work at risk. The Enbrel treatment had no noticeable effects on Crohn’s disease. The Humira treatment started with a 6-fold dose, which led to the first normal bowel movement after 23 weeks after two weeks. Although the symptoms described above occasionally reappear after reduction to the standard dose, but in a significantly reduced form, which is reflected in a weight gain of 6 kg. What remains so far is a certain listlessness and tiredness. Overall, however, I am very happy with both medications.

  2. Tonya E. Elmer says:
    2.0 rating

    Enbrel for Rheumatoid arthritis

    Hot flashes, hourly, with sweats, tags like nights.

  3. Waylon B. Fulk says:
    4.5 rating

    Enbrel for Chronic polyarthritis

    I take Enbrel syringes since the year 2001. Since it already exists as a fully assembled syringe, the injection is also very easy. In the beginning I had to take her twice a week. Since she did a great job with me, even the lowest dose was reduced to once a week and now for 5 years I only need her once every 2 weeks. Except for a huge thirst after spraying (which lasts about 12 hours), there are no side effects. It is a very expensive drug, but luckily it pays the health insurance and I have hardly any complaints.

  4. Susan S. Belford says:
    3.5 rating

    Enbrel for Psoriatic arthritis

    After years of swelling and severe inflammation of the finger joints, finally a drug that works very well. My fine motor skills are back, I can even knit again, grab etc. Good that there is Enbrel.

    Side effects: No side effects
  5. Teresa C. Gonzalez says:
    4.5 rating

    Enbrel for Rheumatism

    I inject by PIN for 5 weeks. The effect was enormous in the first two weeks. I did not need any additional pain medication. In the meantime, it is not so good anymore and I use an additional analgesic several times a week. However, the injection is very painful and the puncture site inflames every time. I also have the impression that I’m gaining weight. Since the beginning of the intake I have gained 2 kg.

    Side effects: Increase in weight
  6. Elease L. Shields says:
    4.5 rating

    My pain disappeared with Enbrel the same day. Sprayed twice a week. However, since then, my immune system is so degraded that I’m permanently sick. Flu infections 3x, herpes 1x, skin fungus on the entire upper body. So, the thing is not worth living!

    Side effects: Infection-susceptibility
  7. Marguerite R. Cane says:
    3.5 rating

    Enbrel for Ankylosing spondylitis

    Enbrel for 8 weeks. After the injection about 1/2 day tired and limp. Difficulty concentrating. Always a bit cold, cough. Otherwise much less pain in the back. Hands and feet still hurt, but not so bad. Less tiredness.

  8. Helen G. Darling says:
    3.5 rating

    I do not want to miss the syringe, I’m fine. Feel fit without pain. have been vomiting and diarrhea every 7-10 days for about 6 weeks. 3-4 hours again and again. Afterwards I have the pain as before the treatment I am tired and sleep all day long. I hope there is a solution wil the syringe did not sell

    Side effects: Fatigue
  9. James K. Williams says:
    3.0 rating

    After Enbrel injection suddenly painless, swelling is decreasing.Better posture. The only fatigue after, otherwise well tolerated.

    Side effects: Fatigue
  10. Jimmy C. Winters says:
    3.5 rating

    Take Enbrel syringe 50 mg per week plus prednisolone 5 mg daily and Quensyl 20 mg 2 times daily. In addition to sticky eyes and dry mouth in the morning, the skin has become thinner. There are no major bruises under the skin.

    Side effects: Mouth dryness
  11. William B. Edwards says:
    3.0 rating

    Enbrel for Ankylosing spondylitis

    Hardly any side effects, Dry skin Psoriasis, Dry mouth Constantly drinking water Herniated disc 4 times otherwise everything is fine, morning stiffness still there about 40 minutes, weakness barely resilient In the evening the battery is all.

    Side effects: Mouth dryness
  12. Monique J. Kato says:
    3.0 rating

    Enbrel for Rheumatism

    Already after the first injection significant improvement, can move all joints again. Frequent infections, dry mouth and thin skin.

  13. Courtney G. Johnson says:
    4.0 rating

    Enbrel for Rheumatoid arthritis

    Hello everybody, my daughter is suffering from rheumatism 2 years ago first she got cortisone pacing every 4 weeks which hardly helped. She decided to give her the medicine MTX which she did not tolerate on the 20th of December she got the drug Enbrel and we After two weeks she had problems with the stairs off or dismounted and complained about Gangunsicherheit.Anfangs I did not worry until she finished school and complained of dizziness, tingling on the head and numb feel on legs and the worst thing was that she did not feel her legs under control. She had to work so hard to run, that she got a very strong headache. She has been in hospital for about 2 weeks. The Enbrel was first discontinued. Physically, nothing was found. First, she continued with the cortisone shock therapy, as she had severe inflammation in her body After the 4-day therapy one has put together what one should do as the running had worsened further and one decided to register her in a 16 days physiotherapy that she is learning to walk again. She makes very good progress and can run quite well again. This morning was the visit and they said that they want to start with Enbrel again she was totally out of her. We do not know what to do. At first they shared everything with us others are excluded but it comes from the Enbrel and now they say it’s not the Enbrel it would be just a Kopfsache.Ich hope you can help me my daughter is 16 years old that means they want me to decide what to do. Do you have similar side effects?

    Side effects: Dizziness; Gang uncertainty
  14. Mayra T. Jimenez says:
    4.5 rating

    Enbrel for Chronic polyarthritis

    My husband – born in 1947 – was treated with Enbrel in 2001 for 3 weeks (6 injections). The treatment had to be stopped because of intolerance (nausea and dizziness). Approximately 2 months later, he got speech, vision and gait disturbances, fatigued quickly, got muscle spasms and tremors in his legs and arms. He was treated neurologically with suspected myasthenia gravis. In 2002, a tetraspastics was added and he was no longer fit for work. Since 2003 he was permanently dependent on a wheelchair and 100% severely disabled. His condition steadily worsened and in 2007, in poor condition, he was transferred to a university hospital, where he had not been a patient until then, and the doctors examined the case from scratch. Although all the investigations concerning the Enbrel treatment had already been made, but without result. In 2009 we received the news that the exclusion trial had led to the conclusion that the Enbrelspritzen administered in 2001 were the trigger for my husband’s tragic condition. I have today an opinion that implies that in 2001 the long-term studies for this drug were not yet completed and you did not know these side effects. My husband was not a tester and certainly would not have taken the remedy if he had known the possible consequences. He has now been treated with rituximab in an attempt for 4 years, which has stopped his illness. There is no cure – END OPEN!! My question is: Has anyone had similar experiences with Enbrel?

    Side effects: Dizziness; Muscle cramps
  15. Camille D. Ingram says:
    4.0 rating

    Enbrel for Arthritis

    Enbrel has greatly worsened my general condition. Nocturnal foot cramps disturbed the night’s sleep. Increasing gear uncertainty in anyway existing Gehbeeinträchtigung. I feel like my muscles are back. Enbrel increased my liver values after a short time. My impaired sense of taste was almost lost. Now I will inject HUMIRA again, because the side effects of this drug were, as far as my general health, more bearable.

    Side effects: Gang uncertainty
  16. Raymond S. Crochet says:
    4.5 rating

    For 7 months after a long fight with the health insurance I take Enbrel with excellent effect. The massive inflammations have since been missed. The pain has decreased significantly and constant extreme tiredness has improved a lot. The only drawback is that Enbrel often burns when spraying. Blood levels are also in the normal range.

  17. Donald C. Clemens says:
    4.5 rating

    Enbrel for Psoriatic arthritis

    Have been trying for 6 years psoriatic arthritis us everything. Years of pain, especially at night. Daily 1 – 2 diclofenac with gastric protector and persistent lack of sleep. 3 weeks ago I got my first syringe Enbrel. After 2 hours I did not have any pain anymore and that has not changed until today. Also, the arthritis disappeared immediately. I can move normally again. I am very happy and hope that everything stays that way.

  18. Sheryl J. Hernandez says:
    3.5 rating

    Enbrel for Rheumatoid arthritis

    I’ve been taking Enbrel for 5 years now (with a low dose of 7.5 mg MTX / week) and I’m fine except for a few small relapses in between. The only thing that annoys me animal are the injection sites the next day. It gets hot, itches and swells really thick and it hurts and annoys when running. When spraying it burns animal, it costs great overcoming every week. And the doctors tolerate it and only think that one should not complain.

  19. Gretchen K. Black says:
    3.5 rating

    Enbrel for Arthritis

    The most unpleasant thing about Enbrel is the spraying, because sometimes it really hurts. The only side effect that really bothered me was the nocturnal leg cramps, all the way up my thighs. Strangely, always early in the morning. Now I take half a tablet of Limptar’N in the evening and the cramps have stopped. The effect of Enbrel on my rheumatism is so good that I have not injected MTX for 4 weeks. I hope it continues.

    Side effects: Muscle cramps