What side effects can Enalapril have?
Below you will find the most important information about possible known side effects of Enalapril.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Dizziness, weakness, visual disturbances (rarely with loss of consciousness without apparent cause), renal dysfunction (rarely to renal failure), dry cough, bronchitis, nausea, abdominal discomfort, indigestion, headache, fatigue, drowsiness, reduction in red blood pigment concentration. !!!
Uncommon side effects:
Excessive lowering of blood pressure, lack of blood cells (decreased hematocrit), reduction of white blood cells, reduction of platelets, cardiac conduction disorders (AV block II and III degrees), dyspnoea, runny nose, sinusitis, Vomiting, diarrhea, constipation, loss of appetite, pancreatitis, allergic skin reactions with rash, redness and itching.
Rare side effects:
loss of consciousness, fainting without apparent cause, nasal mucosal inflammation, vascular swelling (involving the lips, face, larynx and / or arms and legs), drowsiness, depression, sleep disorders, nervous abnormal sensations, balance disorders, confusion, tinnitus , Blurred vision, changes in taste, transient loss of taste, anemia, decreased platelet count, decreased number of neutrophils and eosinophils (specific cells of the body), increased blood urea, increase in blood creatinine and / or blood potassium, decreased blood sodium, cardiac shock, increased blistering, incipient jaundice (Bile-block) until death of liver cells with possible fatal outcome (unclear connection to the intake of enalapril), hives, skin rash with severe disturbance of the general condition.
Very rare side effects and isolated cases: heart palpitations, heart stuttering, chest pain, cardiac arrhythmia, angina pectoris, heart attack, noticeable heart activity, precursors of stroke, stroke, acute renal failure, airway muscle spasm, pneumonia, tongue inflammation, dry mouth, hepatitis, Liver function disorders, intestinal obstruction, severe skin lesions, fever, muscle pain, joint pain, arthritis, inflammation of the vein, increase in the number of white blood cells, increased ANA titer, psoriasis-like lesions, vesicular lesions, skin reactions such as redness, swelling, itching; Rash with skin detachment, photophobia, hair loss, nail detachment, seizures caused by vascular spasms (Raynaud’s symptoms), increased blood bilirubin concentration, increase in liver enzymes, liver dysfunction, liver inflammation, decreased number of all granulocytes (special cells of the body), increase in blood potassium in diabetes, destruction of red blood cells with anemia, increased erythrocyte sedimentation, dissolution / decay of red blood cells, increased sweating.
Side effects without frequency:
Dizziness with changes in body position, weakness, chest pain, sore throat, hoarseness, asthma, water retention in the lungs, inflammation of the mouth, liver failure, skin inflammation with dermal detachment, Stevens-Johnson syndrome, skin dissolution, muscle inflammation, abdominal or Pleurisy, increased erythrocyte sedimentation, hot flash, increased sweating, muscle spasms, nervousness, hemolytic anemia, increase in blood urea and / or blood creatinine levels, increased protein excretion, increased blood bilirubin levels, increase in blood glucose enzyme level.
What interactions does Enalapril show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
The following interactions with Enalapril may affect its effects and side effects:
- Non-opioid analgesics, non-steroidal anti-inflammatory drugs and saline reduce blood pressure reduction.
- Anesthetics, hypnotics and high blood pressure remedies boost blood pressure.
- Immunosuppressants increase the risk of developing blood cell changes. Allopurinol (anti-seizure medication), cytostatics, glucocorticoids and procainamide (anti-arrhythmic agents) potentiate possible blood cell changes.
- Combination with antihypertensives such as AT1 receptor antagonists or aliskiren is not recommended as it increases the risk of side effects such as potassium deficiency, hypotension and decreased renal function. This is especially true in patients with a kidney dysfunction due to diabetes.
- Potassium and potassium-sparing dehydrators (such as spironolactone, amiloride, triamterene) as well as potassium-causing drugs (eg heparin) increase potassium levels. This may reduce the effect of cardiac glycosides.
- Polyacrylonitrile-methallylsulfonate-high-flux membranes (used in the treatment of blood), dextran sulfate (used in the treatment of high levels of blood lipids) and insecticidal toxins in a desensitization therapy increase the risk of allergic reactions by shock.
- Oral antidiabetics and insulins increase the potential for lowering blood sugar.
Enalapril also changes the effects of other drugs:
- Enalapril is used to increase the effects of alcohol.
- It is not recommended to combine with lithium (remedy for manic depression) as it shortens elimination of lithium and increases its toxicity.