About Enalapril

3.0 rating based on 29 ratings
Rating: 3 Reviews: 29
About Enalapril

Enalapril has several uses:

  • In patients with hypertension, the drug may be used as a single therapy or in combination with other antihypertensive agents.
  • For heart failure and asymptomatic sub-left ventricular function, enalapril is given in combination with diuretics.
  • In severe forms of cardiac insufficiency, a combination of enalapril with cardiac glycosides is possible.

Enalapril can also be used in type 1 diabetes-related kidney disease. However, its effectiveness is not fully assured. That is why not all pharmaceutical companies provide their enalapril medicines for this disease.

What is the purpose of this ingredient?

  • Lower blood pressure for high blood pressure
  • Relieve heart in heart failure

This is how Enalapril works

Below you will learn more about the fields of application and the mode of action of Enalapril.
Please also read the information on the drug groups ACE inhibitors, antihypertensives, to which the active ingredient enalapril belongs.

Areas of application of the active substance enalapril

Enalapril has several uses:

  • In patients with hypertension, the drug may be used as a single therapy or in combination with other antihypertensive agents.
  • For heart failure and asymptomatic sub-left ventricular function, enalapril is given in combination with diuretics.
  • In severe forms of cardiac insufficiency, a combination of enalapril with cardiac glycosides is possible.

Enalapril can also be used in type 1 diabetes-related kidney disease. However, its effectiveness is not fully assured. That is why not all pharmaceutical companies provide their enalapril medications for this disease.
For the following uses of Enalapril , more detailed information is available:

  • Hypertension
  • heart failure

Mode of action of Enalapril

Enalapril belongs to the group of ACE inhibitors. The blood pressure reduction of ACE inhibitors occurs in three ways:

  • Blockade of the enzyme ACE (Angiotensin Converting Enzymes) prevents the formation of the hormone angiotensin II in the kidney. Angiotensin II causes a strong contraction on the blood vessels and thus an increase in blood pressure. If ACE is blocked by the ACE inhibitors, practically no more angiotensin II can be formed. The blood vessels relax and the blood pressure drops.
  • Increased salt and water are excreted through promotion of kidney function. This reduces the blood volume and lowers the pressure in the vessels.
  • by direct dilation of the blood vessels by inhibiting the degradation of the vasodilator bradykinin. As a result, bradykinin can work longer, and the blood vessels stay longer.

Enalapril is actually a prodrug: it is itself ineffective and is only converted to its active form enalaprilat in the liver. The gift as a prodrug has the advantage that the active ingredient is better absorbed into the body as its effective conversion product. However, the effect of enalapril is delayed by the conversion. The effect begins approximately one to two hours after ingestion, but lasts for 18 to 24 hours.

Enalapril, or enalaprilat is mainly excreted via the kidneys. Therefore, the doctor must reduce the dose in patients with severe renal impairment and deficient urinary output because the effect is stronger and lasts longer.

Potential Enalapril side effects may include:

Enalapril used to treat the following diseases:

  1. Debra E. Cassell says:
    2.0 rating

    Since taking these medicines, I have already gained 10 kg. Which drug is it, I can not say exactly. My joints are not as strong as before. Before the operation it was the heart strain and now it is the effects of the medication that makes it difficult to climb stairs.

    Side effects: Increase in weight
  2. Brianna K. Dawkins says:
    3.0 rating

    Enalapril for High blood pressure

    At the beginning, I took Xanef 2.5 mg for more than 6 years. After my family doctor said, there is also another drug, which biligerI have been prescribed Enalapril by two different companies. After the change of preparation, the side effects were: headache, gastrointestinal discomfort, nausea, fatigue, tiredness, mental health problems. So it was not a good idea from my family doctor. Have the pills now discontinued because my good family doctor was not able and said the 2.5 mg his anyway almost homeopathic. Well that’s it. By the way, I’m 26 years old this year!

    Side effects: Fatigue; Nausea
  3. Dennis M. Peterson says:
    4.0 rating

    Enalapril for Heart rhythm disturbances; High blood pressure

    Recurring panic attacks and anxiety! In the initial stages often dizziness and nausea.Can reduce the attacks by never taking them sober and now knows that these conditions come from the tablets!

    Side effects: Dizziness; Nausea
  4. Regina P. Owenby says:
    3.0 rating

    After 1 week of taking the coughing started, as well as sore throat. Cough increased so much that I did not come to sleep after 6 weeks at night. The information of my doctor, that goes away again, arrived in any way. After 2 months, the coughing fits were so bad that I had to vomit.

    Side effects: Cough
  5. Dena T. Young says:
    2.0 rating

    Enalapril for High blood pressure

    For a year, I take this drug and suffer from severe irritation cough.

    Side effects: Cough
  6. James V. Swift says:
    4.0 rating

    Enalapril for Heart rhythm disturbances; High blood pressure

    The drug removes the cardiac arrhythmias pretty well. The blood pressure is normally 120 to 80. However, under stress immediately to at least 160 to 120. The irritating cough came a few days after the first time sometimes less severe. Disturbing especially at events (cinema, theater, weight gain despite controlled food about 10 kg with no chance of reduction (experiments with omission of a meal were without result.) Temporarily erectile dysfunction

  7. Michael J. Green says:
    2.5 rating

    Enalapril for High blood pressure

    Take Metoprolol since 2005, sold it on 1.09. Today at 4.09. I’m not tired back pain go back. The sweating is over, already could not go out of the house. Tomorrow something bad. only my tinnitus is still vorhanden.ich do not know if my erectile dysfunction also come through these tablets. I dropped off after reading her reports, Metoprolol and Amlodipine Basics, and my health is generally better. The blood pressure values are in the ok range. I can not feed myself to Enepril and Amlodipin because I had to take them all together. Dieter Dieter

    Side effects: Erectile dysfunction