Eliquis contraindications and warnings


The following provides information on contraindications to the use of apixaban in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should Apixaban not be used?

The use of apixaban is prohibited in case of hypersensitivity to the active substance, if there is a pathological bleeding, kidney failure or the patient requires a blood dialysis, in severe liver diseases and diseases that are associated with a clotting disorder or increased risk of bleeding br>
Apixaban should only be used at

    after a careful risk-benefit assessment by the physician and under his control

  • Diseases with an increased risk of bleeding, such as congenital or abnormal coagulation disorders, existing peptic ulcer, bacterial pericarditis, platelet deficiency or dysfunction.
  • Stroke due to a history of hemorrhage
  • severe uncontrolled high blood pressure
  • Recent surgical procedures on the brain, spinal cord or eyes
  • severe renal impairment (creatinine clearance 15 to 29 milliliters / minute)
  • elderly patients due to their increased risk of bleeding
  • mild or moderate hepatic impairment (Child Pugh A or B) or increased liver enzyme levels in the blood.

What should you watch out for during pregnancy and lactation?

So far, there is no experience with the use of apixaban in pregnant women except from animal experiments. Therefore, the use of Apixaban during pregnancy is not recommended.

It is not known if apixaban or its breakdown products are excreted in breast milk. In animals, this could be demonstrated and thus the risk for newborns and children can not be excluded. The doctor will therefore decide whether to discontinue breast-feeding or to discontinue treatment with apixaban or to discontinue treatment.

What should be considered in children?

The safety and efficacy of apixaban in children under the age of 18 have not been established in studies. Therefore, the use of the drug in this age group is not recommended.

Warnings and Precautions

  • Throughout treatment, the doctor must monitor the patient for signs of bleeding.
  • Prior to treatment and beyond, the patient should be screened for renal impairment by the doctor because they prohibit treatment or require lower doses.

Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.