Eliquis side effects

What side effects can Apixaban have?

Below you will find the most important information about possible known side effects of Apixaban.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).

Common side effects:
Anemia (also due to hip or knee surgery and due to bleeding), bleeding (including bruising and vaginal or urethral bleeding),

Uncommon side effects:
platelet deficiency, low blood pressure (including drop in blood pressure during the procedure), nosebleeds, gastrointestinal bleeding (including vomiting blood and blood in stool), elevation of certain blood levels ( ASAT, ALAT , Gamma-GT, alkaline phosphatase, bilirubin), blood in urine, bleeding after surgery (bleeding, bruising at puncture and catheter puncture sites), wound secretions, bleeding during surgery.

Rare side effects:
Hypersensitivity reactions, bleeding to the eye (including conjunctival haemorrhage), spitting blood, bleeding gums, bleeding from the anus, muscle bleeding.

Special Features:
As with any anticoagulant, the use of apixaban may be associated with an increased risk of hidden or visible bleeding from any tissue or organ. These bleedings can even lead to anemia. The signs, discomfort and severity may vary depending on the location, severity or extent of the bleeding.

What interactions does Apixaban show?

Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).

The concomitant use of apixaban with the antifungals ketoconazole, itraconazole, voriconazole and posaconazole, as well as HIV medications such as ritonavir, inhibits the degradation of apixaban in the body, resulting in greater efficacy and more side effects. The combination should therefore be avoided as much as possible.

The concomitant use of other anticoagulants such as heparin and heparin-like (such as fondaparinux) and coumarins (for example phenprocoumon) is prohibited. Exceptions are the change of therapy from these or these drugs or when heparin is given to maintain the patency of a venous or arterial catheter.

Apixaban, however, degrades faster in the presence of other substances and thus less effective. This is the case with the tuberculosis drug rifampicin, which should therefore not be combined with the active substance. The anti-epileptic drugs phenytoin, carbamazepine and phenobarbital or St. John’s wort (for depression) reduce the effect of apixaban less, but the combination must be done with medical care.

Non-steroidal anti-inflammatory drugs and platelet aggregation inhibitors generally do not enhance the anticoagulant effect of apixaban. Notwithstanding these findings, there may be individuals in whom antiplatelet agents, administered concomitantly with apixaban, are hazardous. Therefore, the physician should be careful when co-administering non-steroidal anti-inflammatory drugs (including acetylsalicylic acid) as these agents typically increase the risk of bleeding.

Potential Eliquis side effects may include: