What side effects can doxycycline have?
Below you will find the most important information about possible, known side effects of doxycycline.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Common side effects:
heartburn, stomach pressure, vomiting, flatulence, fatty stools, diarrhea.
Uncommon side effects: mouth inflammation, pharyngitis, hoarseness, dysphagia, allergic reaction with rash, hives, itching, redness, swelling, headache, joint pain, fever, fluid retention in tissue, erythema exudative multiforme, asthma, anaphylaxis; Photosensitivity with sunburn, fingernail detachment; Blood clotting disorders, blood in the urine.
Rare side effects:
Lyell’s syndrome, exfoliative dermatitis, increased intracranial pressure with headache, nausea and vomiting, blurred vision; Changes in the blood count such as white blood cells or platelets, as well as white blood cells, lymphatic diseases, anemia and altered blood cells; Kidney damage, sensory disturbances, joint pain, rapid heartbeat, muscle pain, restlessness, anxiety, odor disorders, taste disorders, hypersensitivity reactions such as facial swelling, tongue swelling, laryngeal swelling, airway narrowing, palpitations, dyspnea, drop in blood pressure, shock, cardiac arrest.
Isolated side effects:
Black hair tongue, intestinal inflammation, epileptic seizures.
Side effects without frequency:
During therapy with doxycycline, fungal colonization with inflammation of the oropharynx, the gastrointestinal tract or the genitals may occur.
In children, there may be permanent discoloration on the teeth during treatment and, in the worst case, bone growth disorders.
During pregnancy and overdose, the risk of liver damage and pancreatitis is increased.
What interactions does Doxycycline show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Acid-binding agents, laxatives, anion exchange resins, medicinal charcoal, milk and calcium-containing fruit juices slow down the absorption of doxycycline from the gastrointestinal tract and thus its action. Iron-, aluminum-, magnesium- and calcium-containing active substances show the same interaction, but in turn are also inferior. Therefore, all of these drugs should be taken two to three hours after doxycycline.
Doxycycline enhances the effects of anticoagulants and sulfonylureas, therefore, the blood clotting or the blood sugar levels must be checked regularly and the doses of the active ingredients to be adjusted by the doctor.
When barbiturates, primidone, rifampicin, carbamazepine and phenytoin are used as well as chronic alcohol abuse, doxycycline will break down more quickly and may be ineffective. The doxycycline dose must then be increased by the doctor.
The effect of estrogen-progestin combinations for contraception (the pill) may be compromised by doxycycline. Therefore, other contraceptive measures should be taken during the treatment.
Penicillins, cephalosporins and similar antibiotics should not be combined with doxycycline because it may decrease the effect of both antibiotics.
Taking cyclosporine or methoxyflurane (for anesthesia) in combination with doxycycline can cause severe kidney damage. Co-administration of isotretinoin and doxycycline increases the risk of increased intracranial pressure. If theophylline is taken in addition to doxycycline, complaints of the gastrointestinal tract occur more frequently.