Doxepin contraindications and warnings


The following provides information on contraindications to the use of Doxepin in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should Doxepin not be used?

Doxepin should not be used in the case of hypersensitivity to the active substance and related substances (dibenzoxepine). Furthermore, it must not be used in cases of acute alcohol, sleep medication, analgesic or psychopharmacological poisoning, acute delirium, untreated green star, acute urinary retention (lack of urine excretion), prostate enlargement with residual urine formation, paralysis due to paralysis, reduced potassium concentration in the blood / p>
Doxepin should only be used with special medical care in the case of prostate enlargement without residual urine formation, severe liver damage, disorders of the hematopoietic system, brain organic psychosyndrome and increased spasms.

In case of cardiac damage (abnormal conduction such as atrioventricular block, angina pectoris, cardiac arrhythmia, heart rate deceleration) the physician should carefully evaluate the use of doxepin (close-up ECG controls). Patients with pre-existing higher-grade AV block or cardiac conduction disorders should not receive doxepin.

Doxepin must be used only with careful medical control of blood pressure in patients who must be sure to avoid lowering their blood pressure.

In patients with brain organic psychosyndrome, a delirious drug may be induced.

What should you watch out for during pregnancy and lactation?

During pregnancy, Doxepin should be administered only when strictly necessary and after careful consideration of the benefit-risk balance by the physician. After birth, especially after taking higher doses of antidepressants, withdrawal symptoms in the form of disturbances of the heart and respiratory function, emptying of urine and stool as well as restlessness in the newborn were observed.

During treatment, breast-feeding should not be stopped as doxepin passes into breast milk. If treatment is absolutely necessary, it should be weaned.

What should be considered in children?

There is insufficient scientific evidence for the treatment of children and adolescents under the age of twelve, so the product should not be prescribed for this age group.

Warnings and Precautions

  • The blood count, liver functions, blood pressure and ECG must be checked regularly by the doctor.
  • If flu-like symptoms (high fever and chills) or purulent tonsillitis occur, a doctor should be interviewed.
  • If there are inflammations in the genital area, a doctor must be consulted.
  • The use of painkillers or fever must be discussed with a doctor.
  • Treatment with this medicine should not be stopped suddenly because of possible withdrawal symptoms.
  • If signs of over-exertion (mania) occur, the medication should be discontinued as directed by the physician.
  • Especially young adults are suicidal despite treatment with the drug and must be monitored accordingly.
  • The medicine may increase the risk of bone fractures.
  • The responsiveness may be so impaired that driving a car and operating machinery are dangerous.

Sometimes medications release allergic reactions.
If you notice signs of allergic reaction, tell your doctor or pharmacist immediately.