What side effects can Doxepin have?
The following is the key to the possible known side effects of Doxepin.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Uncommon: urinary dysfunction, inner restlessness, thirst, allergic skin reactions, itching, loss of libido, ejaculation disorders, impotence, sweating; in elderly patients: increased risk of confusion, delirium.
circulatory collapse, urinary retention, milk flow from the nipple, disturbances of the conduction of the heart, worsening of cardiac muscle weakness, water retention in the tissue, nervous sensations, heat and cold sensations, tinnitus, increased dreams.
Breast swelling in men, menstrual disorders, breast enlargement, disrupted release of the hormone ADH, hair loss, change in blood sugar levels, liver inflammation with biliary congestion, epileptic seizures, glaucoma cases, decrease in white blood cells, decrease in platelets, anemia. !! !!
Side effects without frequency indication:
Especially at the beginning of treatment: dry mouth, stuffy or dry nose, tiredness, drowsiness, dizziness, low blood pressure, tachycardia, cardiac arrhythmia, tremor, disturbance of extinction, constipation, weight gain, increase in liver enzymes ( usually temporary).
Intestinal paralysis and intestinal obstruction as well as polyneuropathy are side effects of tricyclic antidepressants and can therefore also occur with the use of doxepin.
In patients with a history of alcohol or medication dependence, it can lead to abuse of the Active ingredient come.
The widespread use of the drug has shown that ingestion may increase the risk of fractures.
What interactions does Doxepin show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Concomitant administration of antiarrhythmic drugs (eg quinidine, amiodarone), neuroleptics, antimalarial drugs, H1 antihistamines and antibiotics should be avoided because of the possibility of enhancing cardiac arrhythmias.
So-called irreversible MAO inhibitors should be discontinued at least 14 days before initiating therapy with doxepin. Otherwise serious side effects such as agitation, delirium, coma, over 40 ° C fever, epileptic seizures and severe blood pressure fluctuations should be expected. In hard-to-treat depression in individual cases, the additional administration of MAO inhibitors is possible. The dose of MAO inhibitors should be increased slowly by the doctor.
Other antidepressants, neuroleptics, barbiturates, analgesics, H1 antihistamines (against allergies), anticonvulsants, narcotics and alcohol result in a mutual enhancement of the central depressant effect.
Anticholinergics such as Parkinson’s disease and other tricyclic and tetracyclic antidepressants provide a mutual enhancement of anticholinergic activity.
Cimetidine (against gastric ulcers) potentiates central depressant and anticholinergic effects.
When sympathomimetics or norepinephrine are used concomitantly (also as a vasoconstrictor in local anesthesia), the sympathomimetic effect is enhanced.
In nitro-based vasodilators and antihypertensives such as beta-blockers, the hypotensive effect is enhanced.
Co-administration of guanethidine, reserpine, clonidine and guanfacine results in a reduction in hypotensive activity. With clonidine there is an additional risk of a rise in blood pressure when discontinuing the active ingredient.
At the same time taking active ingredients that reduce the potassium concentration in the blood (for example dehydrating agents), the potassium concentration in the blood continues to drop. This must be avoided.