About Doxepin

3.5 rating based on 137 ratings
Rating: 3.3 Reviews: 137
About Doxepin

Doxepin is used to treat depression and anxiety disorders. It suppresses restlessness, helps with sleep disorders and functional (not physical) organ disorders. It is also used in alcohol and drug withdrawal to suppress mild withdrawal symptoms.

What is the purpose of this ingredient?

  • relieve depression
  • Release fear
  • Reduce withdrawal symptoms in alcohol withdrawal
  • Reduce withdrawal symptoms on drug withdrawal
  • Promote sleep
  • relieve functional (non-physical) organ discomfort

This is how Doxepin works

Below you will learn more about the areas of application and the mode of action of Doxepin.
Please also read the information on the drug groups tri- and tetracyclic antidepressants, antidepressants, to which the active ingredient Doxepin belongs.

Areas of application of the active ingredient Doxepin

Doxepin is used to treat depression and anxiety disorders. It suppresses restlessness, helps with sleep disorders and functional (not physical) organ disorders. It is also used in alcohol and drug withdrawal to suppress mild withdrawal symptoms.

For the following application areas of Doxepin , in-depth information is available:

  • depression
  • anxiety disorders
  • nervous
  • alcohol dependence
  • sleep

Effect of Doxepin

Doxepin is one of the tricyclic antidepressants. It has pronounced calming, anxiolytic and mood-enhancing effects.

As an action mechanism for the effect in the brain an influence of the neurotransmitters serotonin and norepinephrine is assumed. Doxepin inhibits their reuptake into the cells, thus increasing their concentration in the brain and thus unfolding its positive effect.

Doxepin also inhibits the action of the tissue hormone histamine by blocking the H1 and H2 receptors. Doxepin was used to inhibit gastric juice secretion and the development of gastric ulcers under stress in different experimental settings.

Doxepin has a weak anticholinergic and antispasmodic effect both in the brain and in the rest of the body. Like other tricyclic antidepressants, it inhibits the conduction of the heart at high doses (slowing the heartbeat) and lowers the resistance within the blood vessels slightly (lowering blood pressure).

The following effects of doxepin have also been demonstrated in animal experiments: Effectiveness of analgesics, reduction of dependence on opioid analgesics, suppression of withdrawal symptoms in morphine dependence.

Potential Doxepin side effects may include:

Doxepin used to treat the following diseases:

  1. Robert S. Moore says:
    3.5 rating

    Doxepin for Anxiety and panic attacks

    Have used Doxepin differently than prescribed, with only 25 mg instead of 50 mg taken the first time in the evening. That was enough for me, the head was somehow spongy and empty. I have been able to sleep very well for a long time. Before, I woke up at 01:00 or 02:00 clock and have to ring the alarm clock only pondering, five days a week. Unfortunately, I was just as tired the next day, almost the whole day long. Dizziness, sometimes dizziness and a dry mouth could be detected in the morning. However, this has become less and less with time. I am more hungry than usual and have become more balanced. Much is not as important to me now as it was before. I just can not get it right for everyone, which almost made me collapse at work. Because I really suffered, when I did not get something done, or just did not answer the phone, I always had a guilty conscience. Constant fear to forget something or to make wrong, was my previous daily routine. Now after the 50 call until noon, I let it ring once synonymous and make important to the end. It is done one by one and sometimes “no” said to outrageous customers who want to have done everything immediately and best yesterday. For information I am harassed after work hours and also on the weekend of customers, which today is 24 hours a day, seven days a week service normal. Such customers do not bother me at the moment, before they almost ruined my head. The dose has since been increased to 50 mg in the evening and 25 mg in the morning. At the moment, this works quite well, the tiredness in the morning is less and I can still sleep very well. The dose in the morning, was introduced by me independently, because I was very restless, sometimes very easily irritated and also became aggressive. So far it’s ok, let’s see what else is coming. The hoped-for effect of mood enhancement has not yet occurred, I would also wish a little more drive. Then everything would be great. I’m a bit scared of the enormous weight gain, which is often stated here. Can not report anything, except increased hunger. Overall, more positive than negative changes are perceived by me.

    Side effects: Dizziness; Mouth dryness; Fatigue
  2. Tonja J. Hawkins says:
    4.0 rating

    Doxepin for Anxiety and panic attacks

    only 12.5 mg have changed my life. The tingling in the foot I have not got away for a year … help does not help. And the deposition first. I thought I’m dying. it has lasted months … extreme depression panic of everything and perceptual changes that I still have today … eg. I was afraid of an electrical outlet, because it seemed to me that the holes were looking at me. quite a few such things, even the car headlights seemed to me like that …. I was afraid of everything … It has luckily improved … but I’m not the old one anymore. I hope it gets better Escitalopram is 10000 times better

    Side effects: Withdrawal symptoms
  3. Nathan C. Grimes says:
    4.0 rating

    Doxepin for High blood pressure; Sleep disorders

    After Oxigesic80 / 2 Xtgl.Entzugserscheinungen.Jetzt, every 8 hours Tramal100 long! 100% freedom from pain, clear mind. No side effect! Doxepin: 3X25mg.1X50mg.Positv: No more shying people. Driving possible.no pain anymore.Quiet permanent sleep.no panic in crowds. negative: complete loss of libido, 100%, impotent.Very thirsty. Tranxilium10 mg.:No more pondering, deep quiet sleep, sunny mind! no side effect. Rampiril: stable blood pressure120 / 80

  4. Rachael L. Williams says:
    1.5 rating

    Doxepin for Concentration disorders

    Super AD. First days very tired, but the effect was awesome. Like New born!

    Side effects: Fatigue
  5. Arnold P. Hines says:
    2.5 rating

    Doxepin for Polytoxicomania; Alcohol addiction

    This stuff does not help me at all. No effect or side effect. I stunned my tooth with the powder in the capsule until the nerve had died. Was only good for that. Full of novocaine shit that does not do anything unless you can stun teeth with it.

  6. James C. Waddell says:
    3.0 rating

    Doxepin for Migraine; Sleep disorders

    Dosage: 10mg, 1 tablet at night. Has good against my Ein u. Sleep-through disorders helped. I have the experience with the dreams described here, despite the minimum dosage of 1 tablet at bedtime, I have also made. In addition, this drug should also reduce migraine attacks, which I can also confirm.

  7. Shawn M. Clements says:
    2.0 rating

    Doxepin for Migraine

    When I take Maxalt, I usually lie down for an hour because I get tired of it

    Side effects: Fatigue
  8. Beverly N. Sanchez says:
    3.5 rating

    Doxepin for Post-traumatic stress disorder

    I take doxepin as an emergency medication when everything breaks down, and it helps quite well.

    Side effects: Dizziness
  9. Molly D. Moritz says:
    4.0 rating

    Doxepin for Post-traumatic stress disorder; Anxiety disorders; Sleep disorders; Depression

    Doxepin is still very new for me just 1 week. But I have not noticed any great side effects. I had Venlafaxin before. They are not recommended. They had to stop at once because I was so aggressive and restless. That was the hell 300mg at once, I’m still in Dillemer condition. My head feels like a microwave so it makes noise. I sweat and freeze at the same time. Still very aggressive and sensitive. I’m doing everyone hurt in my environment. The shirring is not even know why. Rivotril, help me if I’m not on withdrawal. They let me sleep a few hours without having bad dreams.

    Side effects: Withdrawal symptoms; Sweat
  10. Clayton K. Knowlton says:
    4.0 rating

    Doxepin for Drive disorders; Fatigue; Withdrawal symptoms; Sleep disorders

    Hello I have been taking methadone for 11 years now free for adults and was down from 18ml to 2ml. I currently get 200mg Doxepin per day. Unfortunately, the sedative effect diminishes rapidly and the methadone breaks down faster. At a daily dose of 300-400mg per day has triggered a psychosis with me. Since I have already tried all antidepressants about 30 different know the doctors / psychiatrists not further. Medications that have helped me to focus on and against depressed mood: 300mg-Trevilor a day or 8mg of Reboxetine a day Tricyclic like Doxepin have no antidepressant effect on me or other patients they are only taken on sedating effect and as soon as they stop act against others exchanged (amitryptiline / trimipramine …)

  11. Marilyn J. Howard says:
    4.0 rating

    Initially 3 times 25 mg were not crept in, but administered overnight. The first 14 days I had no side effects, with it was getting better. The panic attacks were less and my mood improved. Unfortunately, then not insignificant side effects occurred, such as: dizziness, low blood pressure, nausea, and weakness. This was so extreme by the day that my feet felt like lead and I had the feeling of falling over during any physical activity. I reduced my dose to half an hour at midday and 25 minutes and a quarter in the evening. The weakness was reduced significantly, my circulatory problems were better. At this dosage, I take Doxepin now about 3 months, but still cause me side effects. Firstly, I have increased considerably, about 5 kilos and I have to eat controlled, otherwise it would probably be more. In addition, I have more often dizziness and nausea, to the point of nausea. Especially bad is the most in the phase of my period.

  12. Megan R. Sawicki says:
    5.0 rating

    Doxepin for Dizziness; Fatigue

    I have been taking Doxepin for about 7 months. Initially I had in the dosage 25 mg morning, noon, evening significant problems with low blood pressure, dizziness, weakness, which was particularly noticeable in activities. I often felt like I had lead in my legs, every movement was difficult, every activity was an effort. I then automatically set the dosage systematically down. Now I take a half 25 mg tablet for breakfast and lunch and only a quarter in the evening. For a while I got along with it quite well, but right now I have the feeling to be more depressed and anxious again. The panic attacks often show up and I get literally cramps. Sometimes I feel confused in my head. I have already tried other medicines, e.g. Cipramil, Mirtazapine, Insidone, Zoloft and all have rather brought negative effects. That’s why Doxepin has been the best cure for my panic attacks so far. I also tried Tavor for a while with Tavor, but I can only advise against that. At the moment it already solves the fears, but they come with decreasing effect all the more. Added to this is the potential for dependence and withdrawal is not exactly the cream.

  13. Carl G. Thompson says:
    4.5 rating

    Doxepin for Sleep disorders; Depression

    Hello, I have been taking Doxepin for about 5 years, mainly because of my sleeping problems. It is a very good medicine! I take 37.5 mg during the working days in the evening and usually 50 mg on weekends. It improves my sleep significantly and I feel a clear stabilization and lightening of my mood. I think everyone has to try out exactly the right dose for themselves. I advise everyone to start with 25 mg. Although one is pretty dazed for about 2 days, then most side effects disappear by themselves. From 50 mg it has unfortunately negative effects for me the next morning. The thinking is then much slower u. you feel a bit dizzy. Also, I have some tinkling, but that’s good to endure. The most important thing is not to give up immediately due to the tiredness of the first days. Also, one should not always increase the dose by 25 mg. I divide the tablets into quarter pieces u. can only recommend this to make u. thus only ever to increase by about 12.5 mg. I’ve tried a lot of sedative AD before u. must say that this helped me the best (with the fewest side effects!) By the way, it is a very cheap AD, that even the family doctor like to prescribe.

  14. Mary D. Simmons says:
    5.0 rating

    Doxepin for Sleep disorders

    I completely discount this drug It helped a little. I had only taken 12.5mg When weaning it was the hell Eo wonder I had committed no suicide I do not want to think back at this time I have thereby got much more fears In addition, hallucinations muscle twitches. I am since then no longer going on since I did not trust any more in this medis That changed my life Had I been able to take drugs Dropping me instantly dropped into a depression I was scared of everything suddenly Everybody has to know it for themselves But this is my experience The dead was I’d rather go through all this than I’m still traumatized Absetzerscheinungen kept months on It changed something in the brain Please finger away.

    Side effects: Depressions; Muscle twitching
  15. Vera R. Preston says:
    3.5 rating

    I have been taking Doxepin for almost 9 years. I suffer from somatization disorders and depression. For me, many side effects have occurred, which I can not name all. It started with heavy, tired legs. Noses bleed, tinnitus, flying mosquitoes, sweating, freezing, pain in the joints, tension in the entire musculature, dry mouth, u.s, w.

  16. Kyle C. Wigfall says:
    4.0 rating

    Doxepin for Sleep disorders

    According to my psychologist, one tablet in the evening (50 mg) is supposed to kill an elephant. Yes, maybe already – but not me. For me the effect goes completely in a different direction! I will not increase the dose either, as I am suffering more from the nice side effects now than the stuff I use. Trembling, joint pain, dry mouth, aggression, leg pain. Conclusion: Does not work for me at all and therefore seems to be nothing for me – so different are the people: o (

    Side effects: Joint pain; Tremble
  17. Lisa G. Crone says:
    5.0 rating

    Doxepin for Sleep disorders

    For me, the drug does not work at all. Oh, yes: Acting it does, somehow: in the evening in bed hot flash with subsequent adrenaline shower and the insurmountable compulsion to just get up again; burning legs with water retention; Binge eating; Restlessness and irritability; Mouth-Sahara; joint pain; Howling cramps and attacks of aggression. Sleep-inducing effect = zero (although my psychologist said that would even upset an elephant). In my view, not suitable for me, so I will bring this spectrum of action in a week with my psychologist.

  18. William H. Couture says:
    3.0 rating

    I got this drug several times after I got a panic disorder or anxiety disorder from smoking. I just got extremely tired and gained weight, and my existing discomfort never got better after a long shot. In addition, my symptoms have increased extremely when taking.

    Side effects: Weight loss; Fatigue