Following is information on contraindications to the use of valsartan in general, pregnancy & breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).
When should Valsartan not be used?
In case of hypersensitivity to valsartan the active substance may not be given.
Valsartan is also banned in patients with severe hepatic impairment, liver shrinkage (biliary cirrhosis), bile duct obstruction, severe renal impairment (creatinine clearance less than ten milliliters per minute) and blood-letting patients. Even diabetic patients or patients with impaired renal function, who receive the antihypertensive drug aliskiren, should not receive valsartan. Valsartan may only be used at
- after careful consideration by the physician and under his control
- Bilateral renal artery stenosis (renal artery stenosis) or unilateral renal artery narrowing in single kidney and the condition after kidney transplant
Patients with valvular stenosis (aortic or mitral valve stenosis) or diseased thickening of the heart muscle (hypertrophic cardiomyopathy).
In case of impaired hormone secretion In adrenal glands (primary aldosteronism), the use of valsartan is generally not recommended. This disease does not respond to AT1 receptor antagonists.
What should you watch out for during pregnancy and lactation?
Valsartan should not be used during pregnancy and breast-feeding.
AT1 receptor antagonists, including valsartan, as well as ACE inhibitors in pregnancy after the formation of the child’s organs can affect their circulation and thus their development. Use in the second and third trimester of pregnancy may therefore cause renal dysfunction, a reduction in the amount of fruit water and slowing of cranial bone growth, and neonatal renal failure, low blood pressure, and excess blood potassium. The intake of ACE inhibitors and AT1 receptor antagonists in the first trimester of pregnancy is not recommended due to lack of data from studies and is expressly prohibited in the period afterwards.
If pregnancy is suspected during pregnancy or pregnancy is planned, valsartan should be discontinued by the attending physician as soon as possible. This will also decide on an alternative therapy.
Since it is not known whether the active substance passes into breast milk, mothers are not allowed to breastfeed during treatment. Therefore, it must be weaned before starting treatment.
What should be considered in children?
Children under six should not receive valsartan. In this age group, there are no experiences with the treatment.
Warnings and Precautions
- Before treatment with the drug, a salt and / or fluid deficiency should be compensated by the doctor.
- Appropriate pregnancy prevention measures should be taken during treatment with the drug.
- Pregnancy should be excluded in women of childbearing potential prior to use of the drug.
- Use caution when treating patients with hepatic impairment.
- Use caution when treating patients with renal impairment.
- Take special care with the treatment of patients with heart disease.
- The drug can affect responsiveness to the extent that driving and operating machines are dangerous.
Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.