From the gastrointestinal tract are possible such phenomena as:
Sometimes can be hepatitis, gastric bleeding.
From the side of the central nervous system can be observed:
- visual impairment
Sometimes, dermatological reactions are possible:
Also, kidney failure, anemia, hypotension or hypertension, menstrual irregularities can be observed. According to recent studies, long-term treatment with diclofenac drugs increases the risk of heart attack by 40%. Therefore, long-term treatment with the drug can be carried out only in the absence of alternatives.
It is not recommended to use diclofenac with other nonsteroidal anti-inflammatory drugs and anticoagulants, as this may increase the risk of side effects, in particular, bleeding. Acetylsalicylic acid reduces the concentration of Diclofenac in the blood. Paracetamol increases the nephrotoxic effect of Diclofenac.
The drug weakens the effect of hypotensive, hypnotics and hypoglycemic agents. With simultaneous administration with antibiotics of the quinolone series, the occurrence of seizures may occur. When taken concomitantly with diuretics, it can help to weaken their action or accumulate potassium in the blood.