What side effects can Diazepam have?
Below you will find the most important information about possible known side effects of Diazepam.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Since the drug diazepam belongs to the drug group of benzodiazepines, side effects that are typical for this substance group may occur. They are:
Drowsiness, drowsiness, decreased attention, decreased responsiveness, sensory disturbances, confusion, difficulty concentrating, muscle weakness, gait, headache, dizziness, tremor, nausea and vomiting, abdominal discomfort, constipation, diarrhea, urinary incontinence, urinary retention, dry mouth, increased salivation, low blood pressure , Pulse fluctuations, circulatory decline, cardiac arrest, changes in sexual desire, itching, hives, flushing, jaundice, epigastric cramps, chest pain, slow heart rate, menstrual disorders in women, increased appetite, respiratory dysfunction, hepatic elevation (transaminases and alkaline phosphatase) / p>
The inhibitory effect on respiratory function may be more pronounced when the respiratory tract is relocated and in patients with brain damage. This should be noted by the doctor, especially when combined with other substances that affect brain activity.
In the morning after the evening taking the drug must be expected after effects (hangover effects) and daytime fatigue.
High doses and prolonged use may cause temporary disturbances such as slow or slurred speech and visual disturbances (diplopia, eye tremors), motion and gait insecurity.
Over time, the drug loses its effectiveness and the patient needs higher doses for the same effect.
Older people taking benzodiazepines may experience more falls and broken bones.
Benzodiazepines, such as diazepam, can cause memory lapses over a period of time, even when used as intended, especially at higher dosages.
An existing and previously unrecognized depression may be evident during the application of the drug.
In the case of the use of the active substance, emotional disorders, such as restlessness, irritability, aggression, anger, nightmares, hallucinations, psychosis, inappropriate behavior and other behavioral disorders can occur, usually in older patients or children. In such cases the treatment should be stopped by the doctor.
Diazepam has a high risk of dependence. Even with daily intake over a few weeks there is a risk of addiction.
When stopping therapy with diazepam, withdrawal symptoms and withdrawal symptoms may occur. The end of therapy should therefore always be prepared with slowly reduced dosages.
What interactions does Diazepam show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Diazepam belongs to the group of benzodiazepines. This results in the following general interactions with other drugs:
- Drugs that affect the brain, such as psychotropic drugs, antidepressants including lithium, sedatives and hypnotics, antiepileptics, opioid painkillers and anesthetics or H1-antihistamines and alcohol, mutually reinforce each other with benzodiazepines.
- Benzodiazepines increase the effects of muscle relaxants, analgesics and nitrous oxide.
The antiulcer drugs cimetidine and omeprazole, the anticonvulsant ketoconazole, the alcoholic weaning drug disulfiram, and the selective serotonin reuptake inhibitors fluvoxamine and fluoxetine (for depression) potentiate and prolong the action because they delay the breakdown of diazepam in the liver.
For diazepam, special attention must be paid to the following interactions:
- The asthma drug theophylline lowers the sedative effect of diazepam in low doses.
- Diazepam may inhibit the action of the Parkinson’s drug levodopa.
- The antiepileptic drugs phenobarbital and phenytoin can help reduce diazepam in the body more quickly and thus have less effect.
- The breakdown of the antiepileptic drug phenytoin in the body can be inhibited and its effects increased.
Due to the slow excretion of diazepam and its metabolites, possible interactions are still to be expected after the end of treatment.
In smokers, the excretion of diazepam may be accelerated and its effects may be diminished or shortened.
In long-term treatment with antihypertensive drugs that also affect the brain, with beta-blockers and anticoagulants such as anticoagulants, interactions are possible whose nature and extent are unpredictable.