What side effects can Duloxetine have?
Below you will find the most important information about possible known side effects of Duloxetine.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Common side effects:
Decreased appetite, insomnia, anxiety, insomnia, excitement, libido reduction, headache, dizziness and vertigo, tremors, listlessness, drowsiness, nervous sensations, blurred vision, high blood pressure, flushing, diarrhea, vomiting, Indigestion, increased sweating, abdominal pain, weakness, chills.
Uncommon side effects:
pharyngitis, hypersensitivity reactions, hypothyroidism, dehydration, confusion, abnormal dreams, listlessness, teeth grinding, abnormal orgasm, poor sleep, attention deficit, nervousness, taste disorder, blurred vision, pupil dilation, tinnitus, earache, palpitations, tachycardia, Fainting, increased blood pressure, yawning, gastrointestinal bleeding, gastrointestinal inflammation, oral mucositis, gastritis, flatulence, regurgitation, bad breath, hepatitis, increased liver enzyme levels (ALAT, ASAT, alkaline phosphatase), acute liver damage , Skin rash, increased tendency to bruising, night sweats, cold sweats, contact dermatitis, hives, muscle cramps, muscle stiffness, pain in bones and muscles, jaw muscle spasm, urinary retention, urinary retention, nocturnal urination, abnormal urine odor, menopausal symptoms, bleeding from uterus or vagina, chest pain, malaise, discomfort, feeling cold, feeling hot, thirst, weight changes, elevated cholesterol level, increase in blood creatinine phosphokinase level.
Rare side effects:
Allergic reaction, blood sugar (mainly in diabetic patients), sodium deficiency in the blood, impaired hormonal regulation of the body’s water balance, suicide attempts, suicidal thoughts, exaggeration, delusions, aggression, anger, serotonin syndrome, seizures , general muscular spasm, pathological agitation, mental restlessness, involuntary movements, movement disorders, restless legs, cataracts, cardiac arrhythmias (predominantly atrial fibrillation), hypertensive crisis, drop in blood pressure on body position change, cold hands, arms and legs, nosebleeds, throat tightness, blood Stool, liver weakness, jaundice, Stevens-Johnson syndrome, facial swelling (angioedema), skin hypersensitivity, muscle twitching.
The treatment must not be stopped suddenly. The doctor must reduce the dose gradually over at least two weeks in order to avoid weaning symptoms as much as possible. Such are: seizures, tinnitus, suicidal thoughts and attempts, aggression and anger.
What interactions does duloxetine show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Duloxetine should not be combined with the following active substances:
- MAO inhibitors (for depression) because of the high risk of serotonin syndrome. No duloxetine should be taken within the first 14 days after stopping treatment with a MAOI; At least five days after stopping duloxetine use, it must be allowed to start taking a MAO inhibitor.
- Fluvoxamine (psychotropic drug) because it greatly inhibits the breakdown of duloxetine in the body and leads to more side effects.
The following ingredients should be used with caution with duloxetine:
- brain-affecting substances (for example, benzodiazepines (sleep aids), analgesics, antipsychotics, phenobarbital (for epilepsy), H1 antihistamines, sedatives).
- Selective serotonin reuptake inhibitors, tricyclic antidepressants (such as clomipramine or amitriptyline), the antidepressant venlafaxine or triptans (for migraine), tramadol (analgesics) and tryptophan (hypnotics) because of the risk of serotonin syndrome.
Also the herbal antidepressant St. John’s wort can lead to increased side effects.
Duloxetine in turn increases the blood concentration of other substances, resulting in more effects and side effects. This is the case for desipramine (psychotropic) and tolterodine (also for urinary urgency), risperidone (neuroleptic) and potent tricyclic antidepressants (such as nortriptyline, amitriptyline and imipramine), flecainide and propafenone (antiarrhythmics) and the beta-blocker metoprolol). Duloxetine increases the risk of bleeding in anticoagulants and platelet aggregation inhibitors.
Because alcohol significantly increases the effects and side effects of duloxetine, but smoking reduces the effect, it should be avoided during treatment >