About Cymbalta

3.5 rating based on 204 ratings
Rating: 3.6 Reviews: 204
About Cymbalta

Duloxetine has four uses:

    • In doses from 20 to a maximum of 40 milligrams, the active substance is used in women for the treatment of moderate to severe urinary incontinence of the stress or stress type. In the case of stress incontinence, the urinary bladder closure is weakened. An increase in pressure, such as occurs when sneezing, coughing, laughing or carrying loads overwhelmed the closure and it comes to involuntary urine output. Stress incontinence, one of the most common types of urinary incontinence, is more common in women than in men. Pregnancy, natural births, connective tissue weakness and aging processes cause the disease.
    • In dosages of 30 to a maximum of 60 milligrams, the drug is used to treat generalized anxiety disorders.

At doses of 60 to a maximum of 120 milligrams, duloxetine is used to treat moderate to severe depression and

  • Nerve pain as part of a diabetes mellitus (diabetic polyneuropathy).

    What is the purpose of this ingredient?

    • Increase muscle tension of the bladder sphincter
    • Promote urinary bladder occlusion
    • Increase the resilience of the bladder sphincter
    • release anxiety
    • lighten depressive moods
    • Breastfeeding pain in diabetic neuropathy

 

This is how Duloxetine works

Below you will learn more about the fields of application and the mode of action of duloxetine.
Please also read the information on the drug groups antidepressants, selective serotonin norepinephrine reuptake inhibitors (sSNRI), to which the active ingredient duloxetine belongs.

Areas of application of the active substance duloxetine

Duloxetine has four uses:

    • In doses from 20 to a maximum of 40 milligrams, the active substance is used in women for the treatment of moderate to severe urinary incontinence of the stress or stress type. In the case of stress incontinence, the urinary bladder closure is weakened. An increase in pressure, such as occurs when sneezing, coughing, laughing or carrying loads overwhelmed the closure and it comes to involuntary urine output. Stress incontinence, one of the most common types of urinary incontinence, is more common in women than in men. Pregnancy, natural births, connective tissue weakness and aging processes cause the disease.
    • In dosages of 30 to a maximum of 60 milligrams, the drug is used to treat generalized anxiety disorders.

At doses of 60 to a maximum of 120 milligrams, duloxetine is used to treat moderate to severe depression and

  • Nerve pain as part of a diabetes mellitus (diabetic polyneuropathy).More detailed information is available on the following Duloxetine application areas:
    • depression
    • anxiety disorders
    • Pain (mild to moderate)
    • Pain (strong to very strong)
    • urinary incontinence

    Mode of action of duloxetine

    For the transmission of nerve stimuli messenger substances must be distributed between the individual nerve cells. The faster these messenger substances are absorbed back into the cells, the faster the nerve stimulation disappears. Agents that inhibit this reuptake result in an increase in nerve stimuli and body functions.

    Duloxetine is a combined inhibitor for the reuptake of the neurotransmitters serotonin and norepinephrine in the nerve cells. Duloxetine thus increases the concentration of serotonin and norepinephrine in different parts of the brain in a dose-dependent manner. This increased concentration reduces the effect of anxiety, depression, and nerve pain caused by diabetes. On the nerve messengers dopamine, histamine, adrenaline and acetylcholine, however, the drug has little influence.

    In animal experiments, an increased concentration of serotonin and norepinephrine in the lower part of the spinal cord leads to activation of the bladder sphincter muscle. In women, a similar mechanism is assumed, which under physical stress leads to a stronger closure of the urinary bladder during the storage phase of the urine. This may explain the effect of duloxetine in the treatment of urinary incontinence-related women.

 

Potential Cymbalta side effects may include:

Cymbalta used to treat the following diseases:

  1. Aaron S. Bowers says:
    4.5 rating

    Cymbalta for Drive disorders; Obsessive compulsive disorder; Adh syndrome; Sleep disorders; Depression

    Cymbalta is the first modern AD which really helps me to look positively and to have the impulse that everyone deserves … I take Cymbalta 60mg every morning / morning After about 40-50 days with Cymbalta, unfortunately, despite the positive improvement also developed an agility and resulting sleep disorders … Trazodon I take daily at 22 o’clock, and I could determine a much better quality of sleep. In addition, I feel less active during the day. Ergo, the nervous side effects of Cymbalta are alleviated and I can sleep better. With this combination I’m feeling better than ever …. I hope that the effect remains constant … I feel really comfortable, a balanced combination of two agents …

    Side effects: Unrest
  2. Jessica S. Murray says:
    3.5 rating

    Cymbalta for Psychosis; Mood swings; Depression

    Seroquel I take since about 6 years … since then, the disease has developed so well back that I can say to lead a normal life again. Of course, the combination with Cymbalta and Ergenyl chrono important ..there are also the depression and the mood swings as good as gone … For about half a year, I take Seroquel prolong … it has only brought me to skidding … but it was probably more of my own fear … that it goes wrong with the drug conversion , and a hospital stay is pending … which has not been confirmed and I am in good spirits with Seroquel Prolong all day long, and also not so tired, after a single take in the evening ….

    Side effects: No side effects
  3. Tiffany M. Drew says:
    3.5 rating

    Cymbalta for Mood swings; Sleep disorders; Depression

    abilify: uneasiness, always having to move, insomnia, lack of appetite, easy dizziness, estimating distances is difficult (often running against it) seroquel: taking in the evening against the insomnia (abilify), immediately tired and sleep like in koma deep and insecure, the next day, it’s hardly possible for me to concentrate, no effort to knock out and too tired for everything.

  4. Diana R. Ramsey says:
    2.5 rating

    Cymbalta for Mood swings; Depression

    At Cymbalta actually no side effects. At Abilify, just at the beginning. Very strong restlessness. At Trevilor. Sweat more.

    Side effects: Unrest; Sweat
  5. Bonita T. Ramirez says:
    4.0 rating

    Cymbalta for A headache

    I got Cymbalta for a strong, one-sided headache. The medication has helped very well against the pain. Unfortunately, after 2 months I got an epileptic seizure (Grand Mal). Cymbalta lowers the seizure threshold. Of course, tablets were discontinued immediately! Still have no effective drug against the severe pain!

  6. Lester R. Villarreal says:
    4.5 rating

    Cymbalta for A headache

    I have strong taste changes with Cymbalta. Any liquids such as mineral water or lemonade you can hardly drink because it tastes so salty and strange. Sometimes I have more of a headache than a reduced one. Hardly any changes with the psyche. I still take 30mg of capsules and still have a lot of fatigue and sleep disturbance after a long time. I am not sure if the sleep disorders come from Cymbalta or rather from my psyche. But since I came back from a clinic where I have been given quite a few medications, I have these suffering sleep disorders. I also got Cymbalta there and was able to sleep at the beginning most of the time. I have not taken most medications for a few months, but I still have permanent sleep disturbances. Although I am not sure if it is due to this drug.

    Side effects: Sleep disorders; Fatigue
  7. Benjamin F. Cyr says:
    4.0 rating

    Cymbalta for Dissociative disturbance; Post-traumatic stress disorder; Depression

    I have tried Jatzt for 2 years many medications. The two medications help me excellent. The quality of life has increased noticeably. I have become much calmer. My long-term fear is no longer so noticeable and the angstlähmungen have declined significantly. Before I had the paralysis twice a day, now once a week. I have almost no side effects. Only my body shows me my fear yet, pulled up shoulders and altered gear and so. But phsyschich I hardly notice anything. Only the libido has risen sharply. I behave like a 20 years old. If you are already 45 and has become used to quiet days, it is annoying if there is always something exciting. Especially because of my post-traumatic stress disorder, I am very difficult to feel able to live. Then such an increased libido is funny.

  8. Christopher L. Espino says:
    4.5 rating

    Cymbalta for Depression

    Cymbalta I take for over 3 years. It helps me to endure my serious illness. The drug helped a lot to survive 3 years of loneliness. Getting a grip on my temper tantrums and helping me become more tollerant, peaceful and loving in my relationship with my partner, Cymbalta. I see as a side effect: Cymbalta makes dependent. You can not and should not simply reduce or sell it! Recommendation: All changes with Cymbalta should ALWAYS be done with a doctor !!

    Side effects: Dependence
  9. Russell S. Johnson says:
    5.0 rating

    Cymbalta for Psychosomatic disorder

    I had a stomach ulcer in 2009 that broke up. My family doctor keeps telling me when I complained of pain that caused his psychosomatic disorders. (Occupation tax advice) Then I got a referral to the neurologist, who prescribed me Cymbalta (only 30 / then 60), although I have no neurotic disorder. For me then after 3 weeks, side effects, such as: bladder weakness, dry mouth, drowsiness during the day, and now after 1.5 years, a habituation occurred. I now vacillate between calm and beauty. Sometimes I feel like I need 2-3 (60mg) a day to get away from nervousness. In addition, I have taken after taking C.60 10 KG, although I am a very athletic person! So these tablets have in my view in addition to the many side effects also a high addictive potential. Simply settling is not possible. In October 2011 (after 2 years of taking) I should let them crawl again half a year. Hopefully I will be a normal person again!

  10. Penny D. Schechter says:
    3.5 rating

    Cymbalta for Migraine; Depression

    Because I suffered from headaches, irritability and depressive moods almost every day, I was prescribed cymbalta. At first I had this tight neck, loss of appetite, mild dizziness and lack of concentration. sudden fatigue and after sleep a high increase in activity were to be noted. Then I wanted to stop the drug and left it just three days away. first it got better and then old symptoms such as compulsive behavior and compulsive thinking came back, of which I noticed nothing under cymbaltaeinnahme. so i decided to continue taking the drug, albeit at a reduced dose. There was no side effect at all when taking this medication again. Only positive aspects were noticeable, such as increased activity, pleasant mood, increased tolerance, lower irritability. There was something like an invisible wall between me and my environment that annoyed me extremely quickly. in the meantime i also have more self-confidence and i do not care so much what people think about me, i am closer and more familiar myself, i have less fear and i can take things more as they are. however, I am also less afraid of weight gain or fewer fears of living, which increases my tendency to cross-border food intake / spending. sometimes I think, now I just put the medium off slowly and look how it is then. But every time I’m a bit afraid to fall into a deep hole … and take it further, hoping that I’m not really dependent on it. that’s the conflict that’s left over. Can I sell it and manage my life without cymbalta? when is the right time?

  11. Irene L. Puig says:
    4.0 rating

    also i have had very bad experiences with cymbalta …. constant fatigue, breathless. It was so bad that I thought I was going to choke. powerless, very high pulse, pain in the nerves, general condition was very bad, no emotion anymore. pulse raced sometimes, so i thought my heart was coming out … i could count on a lot of side effects, it was a bottomless pit for me and so i did not want to live anymore. I could not go to work either, my dog was still holding me up, because he had to get out, otherwise I would have spent the days just sleeping. was always at the doctor and there I was not believed that I felt so bad. I also did not realize that it could come from cymbalta. until I dropped her off and I felt better all of a sudden. by a doctor change I dropped off cymbalta and I am very grateful for that

  12. Clarissa A. Kidd says:
    3.0 rating

    Cymbalta for Depression

    The first 2 weeks of use: Dizziness, nausea, sluggishness, decreased responsiveness, drowsiness, feeling drunk, unable to drive, fast movements (especially when driving as a passenger) caused me extreme dizziness. Negative side effects that I still have: night sweats, sweats during the day, increased sweating, much thirst, dry mouth, increased urination, difficulty concentrating, gastrointestinal problems, headache, body aches, extremely minimized sexual desire, trauma changes, fatigue / fatigue. However, I can live well with these side effects and tolerate Cymbalta otherwise very well!

  13. Dorothy J. Bull says:
    3.5 rating

    Cymbalta for Depression

    I switched my medication from sertraline / seralin / zoloft to cymbalta 1.5 years ago (discontinuation to 60 mg in 20 mg steps every 4 days / mixed transition with simultaneous sertraline reduction). Initially, for about 8 days, I shuddered / shook myself several times a day through my entire body. It tingled, had Hünerhaut and my hair stood me literally, to mountains … but these symptoms resolved after about 2 weeks completely off. I had a weight gain of about 10 kg and struggled to keep my weight … but can live very well with it. What really bothers me (e) is the totally heavy sweat in all situations … barely moving a bit (for example, walking a little faster as normal), I run out of all a waterfall coming over me. Among them suffered the quality of life enormously! Now I only have 30 mg Cymbalta and the sweating is gone!

  14. David A. Clark says:
    3.5 rating

    Cymbalta for Sleep disorders; Depression

    Hello my dears, after about a year of taking CYMBALTA against Depris, z.T. in combination with MIRTAZAPIN for insomnia, I also got sulpiride prescribed. The combination effect CYMBALTA / SULPIRID was just very good and has worn me nicely. Anyone who does not have enough Cymbalta should try the combo with SULPIRID. Due to the indispensable MIRTAZAPIN I unfortunately have to live with enormous weight gain. Recently (for about 6 weeks) I get additionally prescribed LYRICA, of which I must report rather negative. For one, I hardly feel a positive effect, on the other hand, the medi is very wrong. It increases my sleep disorders quite badly, leads to water retention in the legs (swelling) and the lungs (shortness of breath, shortness of breath). The concentration also worsens, sometimes with articulation disorders. In addition, there is rarely a tingling sensation on the skin, z.T. only on the extremities, z.T. also on the whole body, e.g. with a strong cough … (yes, I’m a smoker !!!) Will the medi therefore sneak out.

  15. Carolyn J. Goss says:
    3.5 rating

    Cymbalta for Depression

    I now take cymbalta the second time and get along really well with the drug. only the first 1-3 weeks can be stressful. I myself had to struggle with some side effects.

  16. Roger S. Harris says:
    4.5 rating

    Cymbalta for Adh syndrome

    When discontinuing Cymbalta, you have the problem that the dose can only be roughly categorized. There are capsules with 60mg and 30mg. It would be important but a much finer gradation to gently crawl the drug, otherwise withdrawal symptoms are practically inevitable! Luckily, there is a simple trick! The capsules can be pulled apart easily! So you can remove a part of the granules before you put the cap back on. The filling quantity is best checked with a scale that you keep next to it_kapsel With this simple trick, the dosage can be fine-tuned as desired and withdrawal symptoms should be significantly less severe.

  17. Elmer P. Gagnon says:
    4.5 rating

    Cymbalta for Adh syndrome

    The effectiveness against ADS is subtle but positively noticeable. From about the 10th day of the intake I felt more concentrated, alert and better organized. In any case, productivity has increased. The mood has remained neutral, but the inclination to ponder and climb into something has decreased. The first 14 days were fierce! I took 60mg right from the beginning, as prescribed by the doctor. The first two weeks I have observed the following: + Improvement of night sleep + Calming of the digestive system, up to constipation + Less watery eyes in cold draft + Increase in concentration from the 3rd day – Libido loss – strong sweating – Dry mouth – Violent muscle stiffness – permanent Yawning – Afternoon tiredness – increased pimples and skin problems Fortunately, muscle stiffness has fallen to a bearable level after two weeks. What remains are: – heavy sweating – yawning – afternoon tiredness (mentally awake but physically tired) – skin problems – loss of libido (slightly better than in the initial phase) – dry mouth – no improvement in sleep quality – digestion back to normal – inability to take a nap ( no falling asleep more possible) – Increased hunger pangs – Vita Merfen seems to be bad for skin wounds Basically, I feel comfortable with the drug. The strong daily fluctuations of the past have declined significantly. But the side effects are relatively strong and disturbing. I will probably discontinue Cymbalta after consultation with the doctor, because the benefit does not outweigh the side effects. Also, Cymbalta is relatively expensive. Tip: The capsules are easy to pull apart and remove some of the granules. I will certainly apply this on weaning to steer the medication out steplessly. From the manufacturer, I wished me a settling pack, which already contains capsules with decreasing dosage.