What side effects can rosuvastatin have?
Below you will find the most important information about possible known side effects of rosuvastatin.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Common side effects:
Diabetes, headache, dizziness, constipation, nausea, abdominal pain, muscle aches, weakness.
Occasional side effects:
itching, fugitive rash, hives.
Rare side effects:
Hypersensitivity reactions including blood vessel swelling, pancreatitis, muscle discomfort (including muscle inflammation), muscle breakdown, elevated liver enzymes (transaminases).
Very rare side effects:
Nervous disorder (polyneuropathy), memory loss, jaundice, hepatitis, joint pain, blood in the urine.
Side effects of unknown frequency:
Cough, difficulty breathing, diarrhea, severe skin reactions (Stevens-Johnson syndrome), water retention in the tissues (edema).
Muscle pain from unexplained cause, muscle weakness or muscle spasms are to be reported immediately to a doctor, especially if they are accompanied by malaise or fever.
Like all statins, rosuvastatin may increase blood sugar levels and promote the development of blood sugar (diabetes mellitus). Frequency is dependent on the presence or absence of other risk factors, such as pre-existing excess blood sugar, obesity, high blood pressure, and the extent of the lipid metabolism disorder.
What interactions does rosuvastatin show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
During co-administration with rosuvastatin and ciclosporin (for organ rejection after transplantation) there may be a higher concentration of rosuvastatin in the blood. This increases the likelihood of side effects.
As with other statins, the risk of bleeding at the beginning of treatment or at an elevated dose may increase if patients receive blood thinners such as warfarin or phenprocoumone at the same time. The blood clotting must therefore be carefully monitored by the doctor in such cases.
Other blood lipids such as gemfibrozil, fenofibrate and other fibrates, as well as niacin (nicotinic acid) in doses of 1 gram / day and higher, increase the risk of muscle damage when co-administered with rosuvastatin. Therefore, a dose of 40 milligrams of rosuvastatin / day is prohibited if fibrates are used at the same time.
HIV-1 protease inhibitors (against HIV infection or AIDS) can significantly increase the effects and side effects of rosuvastatin. Therefore, co-administration of rosuvastatin is not recommended in HIV patients receiving protease inhibitors.
Acid-binding agents with aluminum and magnesium hydroxide reduce the effectiveness of rosuvastatin by half. This effect was attenuated when antacid was given two hours after taking rosuvastatin.
Concomitant use of rosuvastatin and the macrolide antibiotic erythromycin significantly attenuates the effects of the lipid-lowering agent. This interaction is likely to be caused by an increase in bowel movement triggered by erythromycin.
The simultaneous administration of rosuvastatin and the pill leads to a significant increase in the effect of hormones by about one-third. This may also apply to estrogen-progestagen combinations for menopausal symptoms. This must be considered by the doctor when choosing the dosage of the hormone preparations mentioned.