Following is information on contraindications to the use of clozapine in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).
When should Clozapin not be used?
In case of hypersensitivity to clozapine and structurally related neuroleptics, the active substance should not be used.
If the patient has developed a severe white blood cell depletion (agranulocytosis) in previous clozapine treatment, the product should never be used again. People with blood disorders or bone marrow damage should not be treated.
At the same time as clozapine no active substances should be given, which can also cause blood formation disorders. Even if there is no possibility of regular blood count control, clozapine therapy is prohibited.
Furthermore, in untreated or poorly treated epilepsies, poisoning-related psychoses (for example as a result of alcohol abuse), severe brain disorders (for example due to dementia), clouding of consciousness, severe heart or kidney disease, liver disease, jaundice, liver failure as well Intestinal paralysis (ileus) to refrain from treatment with clozapine.
Only after careful consideration of the benefit and risk by the physician, the drug for diabetes mellitus, prostate enlargement and in older people with poor general condition apply.
Also with increased intraocular pressure (green star) caution is necessary and regular checks are necessary.
What should you watch out for during pregnancy and lactation?
Pregnant and breastfeeding women should not be treated with clozapine.
Mothers who take the drug in the last trimester of pregnancy endanger their newborns by causing side effects such as movement disorders and withdrawal symptoms. These can be in excitement, muscle tension or flaccidity, tremor, drowsiness, dyspnoea or disturbances in food intake. Such newborns must be carefully monitored by a doctor.
What should be considered in children?
Children and adolescents under the age of 16 should not be treated with clozapine.
Warnings and Precautions
- There is a risk of agranulocytosis, frequent blood count checks are necessary.
- Patients should not drink alcohol during therapy.
- The ability to react may be reduced, the ability to drive on the roads and to operate machines is limited.
Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.