About Clozaril

4.0 rating based on 13 ratings
Rating: 3.9 Reviews: 13
About Clozaril

Clozapine is used to treat severe schizophrenia when other neuroleptics are not effective enough. It is sometimes also used to treat psychosis in the course of Parkinson’s disease.

What is the purpose of this ingredient?

  • Block dopamine and serotonin receptors in the central nervous system
  • reduce anxiety and agitation
  • Relieve symptoms of schizophrenia
  • relieve psychosis

This is how Clozapin works

Below you will learn more about the fields of application and the mode of action of clozapine.
Please also read the information on the drug group neuroleptics,
to which the active ingredient clozapine belongs.

Areas of application of the active substance clozapine

Clozapine is used to treat severe schizophrenia when other neuroleptics are not effective enough. It is sometimes also used to treat psychosis in the course of Parkinson’s disease.

Initially, the drug should only be given in small doses, which can be slowly increased if tolerated. Even when weaning a slow dose reduction is necessary. Due to the strong side effects, only the lowest dose should be administered which achieves the desired effect.

More detailed information is available for the following Clozapin application areas:

  • Parkinson’s disease
  • psychosis

Effect of clozapine

Clozapine belongs to the group of neuroleptics. Because it binds to receptors of the messengers dopamine and serotonin in the central nervous system, it is also referred to as an atypical neuroleptic.

On the one hand, clozapine dampens arousal states and anxiety disorders, on the other hand it improves memory and concentration. Due to strong side effects, however, it is only used when other active ingredients do not achieve the desired effect.

Potential Clozaril side effects may include:

Clozaril used to treat the following diseases:

Disease
Percentage

78%

  1. Joshua S. Simmons says:
    3.5 rating

    Clozaril for Psychosis

    After 9 years you are broken. (300 mg / d Leponex) healthy lifestyle: no alcohol, no cigarettes, sports following sequelae – increased liver enzymes (slightly fatty liver) – anxiety after a best. Time interval after intake of the med. – increased salivation – anxiety attacks – increased blood pressure and heart palpitations (increased heart rate) – itching all over the body discontinuation of the medication is now desired (but other reports are hardly possible anymore) Attention!

  2. Chris K. Axelson says:
    2.5 rating

    Clozaril for Psychosis

    Because of a severe schizophrenic psychosis 1998 Leponex get. Very effective, but increased appetite, weight gain, elevated liver enzymes (gamma-GT).

  3. Teresa E. Estrada says:
    4.5 rating

    Clozaril for Psychosis

    Substantial increase in body weight, chest pain, fungal infection, cystitis, listlessness, tired. Discontinuing the medication led to schizophrenia again, so I am probably dependent on this for my entire life. Take Seroquel 300 mg in the morning and in the evening, side effect as above. Become in two days on Seroquel Prolong 300 mg again in the morning and in the evening, let’s see what happens. Hope to reduce the intake of 100 to 200 mg in the evening. The use of Leponex was the horror, have increased within six months 20 kilos and once a week had to lose blood with patient passport, since this drug has very serious side effects. At the same time Lyogen was taken which was calming.

  4. Jacqueline J. Avery says:
    4.5 rating

    The worst thing for me was the strong increase in appetite, probably due to the continuous salivation. I gained 30 kilos in weight within 6 weeks. This also gave me stretch marks on the buttocks, chest and abdomen, thighs and arms. In addition, I was a lot dizzy, I was tired and very impulsive. The concentration was severely limited, which I never had before starting therapy. When weaning, I had withdrawal symptoms such as difficulty sleeping, sweats, tachycardia. Within a few weeks, I lost weight, which I gained with the medicine. The hubs on the body have remained natural.

  5. Elizabeth J. Pulido says:
    4.5 rating

    Lingering speech disorder sometimes strongly attenuated

    Side effects: Language disorders
  6. Elmer B. Patrick says:
    4.5 rating

    I have been suffering from paranoid schizophrenia for several years now. I was hired on Leponex during my last spurt last year. At the hospital I received a dose of 500mg distributed throughout the day. After some time, my health improved. With this drug, blood tests are essential (luckily, as I later discovered) because this drug can affect the composition of the blood in some patients (in simple terms). Normally, Leponex is used only in patients who are not helped by any other remedy, I think I am not in this group of people. I took before hiring on Leponex Haldol, in conjunction with zotepin which helped wonderfully to the point of my renewed thrust. For fear of the side effects at a higher dose Haldol agreed to switch to another drug, in the case of Leponex (which I regret!) … But now to the real issue Leponex. Already in the hiring phase for the drug, the first side effects turned up. I was very dazed shortly after taking 50mg and barely able to walk. I was always tired and every movement I made was agony. I complained of increased salivation and urinary incontinence. I also had high blood pressure. My way of thinking has changed, which means that my thinking was inhibited and I did not have much to tell anymore. My head was empty. I got difficulty swallowing, so I woke up in the night and struggled for breath, because I had swallowed (very uncomfortable …). My breathing changed, meaning I could not breathe properly after taking it and my breathing slowed down and shallower. I gained 20Kg during that time. I got hunger attacks and sometimes had no sense of satiety. I had difficulty seeing and could only see blurred. After discharge from the clinic I talked to my doctor about it and we reduced the dose. This only partially helped most of the side effects remained. My doctor is of the opinion that the medium does not change because it despite the side effects still helps. I have to go to the blood control because of the remedy as well, that’s just fine! Because, as it turns out, since the last blood sample, my liver values and my blood scorers have increased! I’m seriously worried about my health! Next week I will talk to my doctor again and for me it is clear I will definitely stop using the remedy! These are my experiences with the drug. I must say I have in my circle of acquaintances someone who takes the same remedy and complains of dizziness after taking any other side effects. Everyone reacts differently to the medication.

  7. John V. Keitt says:
    4.5 rating

    Clozaril for Psychosis

    I have been taking the drug for 16 years now. After slipping into a schizophrenic psychosis at 17, various medications were tried (such as Meleril), but none of them did. Only after administration of Leponex (then 2-3 doses daily) were the symptoms of my illness (concentration disorder, anxiety, depression) better. However, the side effects were not without. The hunger attacks caused a rapid increase in weight, the salivation was boosted, so I vollsabberte pillows and sheets. The medication also made me extremely tired and lethargic, so helping only regular sports and occupational therapy helped me out of the mud (I was a total of 10 months in child and adolescent psychiatry, then in a dorm) Dose (I’m in the process of getting rid of the stuff and taking only 12.5 mg 🙂 I always feel that Leponex has an impact on my personality and empathy. I always compare that to a veil that focuses on my personality and filters and dulls everything. But despite all criticism of this condition – that is the point of this medicine and its protective effect. Not an easy thing to write down criticisms for psychotropic drugs. But I can conclusively and honestly say that I am very happy to have received this drug. I certainly would not feel the same way now (I graduated from high school, have an education, worked in the music industry for several years and am now self-employed), I would not have gotten Leponex. Unfortunately, my cousin was not so lucky and the drug was late. He lives since over 30 years with the symptoms and is cared for ….

  8. Maria G. Titus says:
    4.5 rating

    Clozaril for Psychosis

    I’ve been taking the drug for 10 years now and have blatant side effects with constipation, fatigue and food cravings. I can eat as much as I want and still feel no sense of satiety. That’s why I’ve gained over 15 pounds. I feel choppy and impotent. Whether this is the result of Leponex or symptom of depression, I can not judge. In any case, inside I feel like dead and mostly can not feel feelings like joy or sadness. I only take the medicine because the others, such as Decentan and Solian, did not work.

  9. Alice B. Ragsdale says:
    4.0 rating

    Clozaril for Psychosis

    My acquaintance had only taken Leponex for 10 or more years and still kept her normal weight. Then she changed over to a doctor on Zyprexa and from time to time she got fatter. Even when she later received Leponex again, the weight gain continued. Now she is obese, more likely to be on the increase than to lose weight, smokes, as most neuroleptics strong, suffers from a disorder of cholesterol metabolism, is non-initiative, vegetates, sleeps 12 and more hours, the delusions did not heal well or new relapses are not prevented, constipation, loss of libido. Basically, she gave up and gets herself around the corner this way. Later diabetes and the metabolic syndrome are foreseeable, not to mention myocardial infarction and others. She has given up hope and the desire for a normal life and the contact to healthy people.

  10. Bradley S. Harting says:
    1.5 rating

    Clozaril for Psychosis

    fatigue, increased salivation during sleep otherwise well tolerated

    Side effects: Salivation; Fatigue
  11. Rachel W. Johnson says:
    4.0 rating

    Clozaril for Psychosis

    chronic constipation, intestinal paralysis, up to 17 h sleep, significant weight gain, reduction in white blood cells, licking, salivation, sudden drop in blood pressure, low blood pressure, libido loss