Clopidogrel contraindications and warnings


The following provides information on contraindications to the use of clopidogrel in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should clopidogrel not be used?

Clopidogrel should not be taken at

  • Hypersensitivity to the active substance
  • severe liver dysfunction
  • existing bleeding.

Only after careful consideration of the benefit / risk by a physician and under his control the active substance may be used in

  • Hypersensitivity to chemically related substances such as ticlopidine or prasugrel
  • increased risk of bleeding from injury (especially in the eye or in the eye), surgery or other bleeding disorders
  • Condition immediately after a stroke
  • renal dysfunction
  • moderate liver dysfunction, because of the increased risk of bleeding.

Prior to surgery, treatment with clopidogrel must be stopped. Because of the long-term effect, a period of seven days is required. The doctor or dentist should be told to take clopidogrel if surgery is planned or if a new drug is to be taken.

What should you watch out for during pregnancy and lactation?

There is still insufficient research into whether clopidogrel harms the unborn child. In animal experiments, no damage to the unborn child was found. Whether the drug passes into human breast milk is not yet known. In studies on rats, however, clopidogrel was detected in breast milk.

Therefore, no use of clopidogrel should be made during pregnancy or lactation. For safety’s sake, it should be weaned during treatment with the active ingredient.

What should be considered in children?

In children and adolescents under the age of 18 years, the efficacy of clopidogrel is questioned. Therefore, as a precaution, the drug should only be given to adults and should not be used at this age.

Warnings and Precautions

  • Any observed bleeding must be reported to the attending physician.
  • If signs of liver damage such as weight gain from water retention in the abdomen, itching,
  • The drug must be discontinued seven days before surgery.
  • Patients with gastric or intestinal ulcers must be carefully monitored for medical treatment during treatment with the drug.
  • If there is anemia, a nervous deficiency or fever during treatment, contact a doctor immediately.
  • The combination of the drug with proton pump inhibitors (to reduce gastric acid secretion) must be avoided. Instead, the doctor may prescribe the drug ranitidine.

Sometimes medications release allergic reactions.
If you notice signs of allergic reaction, tell your doctor or pharmacist immediately.