Clonidine is used in tablet form or as a solution for injection to reduce blood pressure in hypertension and normalize blood pressure over time.
What is the purpose of this ingredient?
- Normalize elevated blood pressure
- Lower elevated intraocular pressure in cataracts
This is how Clonidine works
Below you will learn more about the fields of application and the mode of action of clonidine.
Please also read the information on the drug class alpha-sympathomimetics,
to which the active ingredient clonidine belongs.
Areas of application of the active substance clonidine
Clonidine is used in tablet form or as a solution for injection to reduce blood pressure in hypertension and to normalize blood pressure over time.
Clonidine is used in the form of eye drops to lower the increased intraocular pressure in cataracts.
For the following application areas of Clonidine , in-depth information is available:
- Green Star
Mode of action of clonidine
Clonidine belongs to the active ingredient group of the alpha-sympathomimetics effective in the brain and exerts its effect exclusively on the alpha-2-receptors. Alpha-2 receptors are special binding sites of the sympathetic fibers of the autonomic nervous system. Unlike alpha-1 receptors, they have no “turn on” function for sympathetic nervous system activity, but a “turn off” function. Clonidine acts on these receptors as well as the body’s messenger substances, only stronger and longer.
At the heart, clonidine lowers the number of heartbeats and thereby the volume of blood pumped. In addition, clonidine causes a widening of the arteries and veins. With dilated vessels, less blood volume and larger vessel diameter, the blood from the heart has to be pumped through the vessels with less pressure. As a result, the blood pressure drops. This effect is further supported by the fact that clonidine on the kidney attenuates the release of the blood pressure enhancing hormone renin.
On the eye, clonidine causes an improved outflow of aqueous humor. By contracting certain muscle fibers, the drainage channel (Schlemm’s canal) is opened, allowing faster drainage. In addition, clonidine can also slightly reduce the production of aqueous humor, which lowers the intraocular pressure.