Clindamycin contraindications and warnings


The following is information on contraindications to the use of clindamycin in general, pregnancy, breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should clindamycin not be used?

Clindamycin should not be used in case of hypersensitivity or allergy to this substance or to any other agent of the lincosamides group. Here there is a risk of a life-threatening allergic shock.


    may only be used under careful medical supervision and after risk-benefit assessment

  • are given internally (via the gastrointestinal tract, vein or muscle) in impaired liver function, acute or chronic bowel disease, myasthenia gravis and Parkinson’s disease
  • are used externally on the skin, but also in the vagina in intestinal diseases such as Crohn’s disease, ulcerative colitis or mucosal inflammation of the small and large intestine.

If you have an allergy to penicillins, you may experience concomitant clindamycin allergy. Even with only a general feeling of allergy, the doctor must carefully weigh the risks and benefits of therapy with the active ingredient against each other.

Clindamycin is not given for infections with clindamycin insensitive pathogens (for example, yeast fungi and trichomonads = flagellates).

Clindamycin should only be given diluted in the vein. Otherwise it could lead to intolerance reactions such as nausea, feeling hot or rarely even to dangerous heart and circulatory problems (for example, the drop in blood pressure or cardiac arrest).

What should you watch out for during pregnancy and lactation?

The safety of clindamycin in pregnancy is not well established. Therefore, the benefit and risk of an application must be carefully weighed up by the attending physician.

In pregnant women with an increased risk of complications and deep-seated cakes that partially or completely cover the internal cervix, or even when the mother cake is detached, no local application in the vagina should be made.

In the first trimester of pregnancy, use in the vagina should generally only be made after careful medical consideration of risks and benefits.

Clindamycin is transmitted through breast milk to the baby. Diarrhea, fungal colonization of the mucous membranes or the emergence of an allergy can occur in infants. As a precautionary measure, the mother should be breast-feeding before starting treatment.

What should be considered in children?

Infants from 4 weeks of age and infants may receive medications containing the active substance clindamycin. The dose is determined individually by age and body weight by the attending physician.

Warnings and Precautions

  • If you are taking the medicine for more than three weeks, check your liver, kidney and blood levels and kidney function regularly.
  • Severe and persistent diarrhea during treatment may be a life-threatening disease (pseudomembranous enterocolitis). You must see a doctor immediately.
  • If an acne is treated with the drug, the skin should improve within four weeks. Long-term use is not recommended.
  • The drug should not be applied to the eye locally.
  • The drug is not suitable for the treatment of meningitis (meningitis). The concentrations reached in the brain fluid are too low.

Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.