What Side Effects Clindamycin Can Have?
Below you will find the most important information about possible, known side effects of clindamycin.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Common side effects:
Ingestion: Gastrointestinal disorders such as abdominal pain, diarrhea, nausea, vomiting.
For use in the vagina: cervical infections, vaginal mucosal infections.
Uncommon side effects:
If taken: transient liver function increase.
When given into the muscle: local irritation, local pain, local hardening, local sterile abscesses.
When given into the vein: pain, phlebitis.
When applied in the vagina: external genital irritation.
Rare side effects:
Ingestion: allergies (rash-like redness), skin swelling, joint swelling, drug fever, regressive erythema, muscle weakness, itching, vaginal discharge, variegated, weeping skin redness, flaky skin inflammation, Lyell’s syndrome (blisters and skin peeling similar to scalded skin).
For use on the skin: headache, sore throat, skin dryness, frequent urination, contact allergy.
For use in the vagina: rashes (eczema), hives.
Very rare side effects and isolated cases:
If taken: life-threatening allergic shock, transient hepatitis (with skin yellowing), polyarthritis (arthritis), pseudomembranous enterocolitis (severe intestinal inflammation of the small and large intestine).
For use in the vagina: gastrointestinal disturbances such as heartburn, nausea, abdominal pain, diarrhea, constipation, dizziness, headache, transient increase in liver enzyme levels, allergies (rash-like redness), skin swelling, joint swelling, drug fever, again regressive erythema, muscle weakness, itching, vaginal discharge, variegated, weeping skin redness, flaky skin inflammations, Lyell’s syndrome (blistering and skin peeling similar to scalded skin).
Side effects without frequency:
When taking: mouth inflammation, esophagitis.
When used in the vagina: yeast fungus propagation, trichomonad propagation.
What interactions does clindamycin show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
clindamycin and macrolide antibiotics (such as erythromycin, clarithromycin, roxithromycin, azithromycin) weaken each other in their effect from.
If muscle relaxants (such as baclofen, tizanidine, tolperisone) or anesthetic gases (such as diethyl ether, nitrous oxide, halothane, enflurane, isoflurane, desflurane, sevoflurane) are administered with clindamycin, may lead to a stronger muscle debilitating effect.
If clindamycin administered as a solution in the bloodstream (such as infusion), it may in no case with aminophylline (for bronchodilation), ampicillin (broadband penicillin), calcium (calcium substitution agent), magnesium sulfate (magnesium substitution means) phenytoin sodium (antiepileptic) or active compounds from the group of barbiturates (sedatives) as methohexital, thiopental and phenobarbital are mixed.
An altered intestinal flora during clindamycin treatment may make it more difficult to take birth control pills. Therefore, additional mechanical contraceptive measures (condoms) should be used.
When clindamycin is used with vitamin K antagonists such as warfarin, acenocoumarol or fluindione, increased blood clotting and / or bleeding may occur. The doctor will therefore carefully check the blood coagulation levels in patients treated with vitamin K antagonists.